Motif ID: Etv6

Z-value: 0.940


Transcription factors associated with Etv6:

Gene SymbolEntrez IDGene Name
Etv6 ENSMUSG00000030199.10 Etv6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv6mm10_v2_chr6_+_134035691_1340357170.455.9e-02Click!


Activity profile for motif Etv6.

activity profile for motif Etv6


Sorted Z-values histogram for motif Etv6

Sorted Z-values for motif Etv6



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_109459843 1.424 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr11_-_35834492 1.293 ENSMUST00000018992.3
 Rars
arginyl-tRNA synthetase
chr2_+_84840612 1.036 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr4_+_118409331 0.987 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr8_+_105297663 0.959 ENSMUST00000015003.8
 E2f4
E2F transcription factor 4
chr19_+_6084983 0.946 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr15_-_9140374 0.935 ENSMUST00000096482.3
ENSMUST00000110585.2
 Skp2

S-phase kinase-associated protein 2 (p45)

chr11_-_94653964 0.930 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr5_-_149636164 0.924 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chrX_-_141725181 0.913 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr4_+_155943992 0.854 ENSMUST00000118192.1
ENSMUST00000105582.1
ENSMUST00000105581.3
 Ube2j2


ubiquitin-conjugating enzyme E2J 2


chr4_+_155943824 0.842 ENSMUST00000103175.1
ENSMUST00000166489.1
ENSMUST00000024056.3
ENSMUST00000136492.1
ENSMUST00000105583.2
ENSMUST00000152536.1
 Ube2j2





ubiquitin-conjugating enzyme E2J 2





chr7_+_127233044 0.829 ENSMUST00000106312.3
 Zfp553
zinc finger protein 553
chr1_-_183221529 0.823 ENSMUST00000003035.5
 Disp1
dispatched homolog 1 (Drosophila)
chr7_+_127233227 0.821 ENSMUST00000056232.6
 Zfp553
zinc finger protein 553
chr14_+_47298260 0.818 ENSMUST00000166743.1
 Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr9_+_48450327 0.802 ENSMUST00000165252.1
 Gm5616
predicted gene 5616
chr11_+_120948480 0.795 ENSMUST00000070653.6
 Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr11_+_118428493 0.752 ENSMUST00000017590.2
 C1qtnf1
C1q and tumor necrosis factor related protein 1
chr14_-_101640434 0.723 ENSMUST00000168587.1
 Commd6
COMM domain containing 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 1.8 GO:0006413 translational initiation(GO:0006413)
0.4 1.6 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)
0.1 1.6 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 1.4 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.3 1.3 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.2 1.1 GO:0090005 negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 1.1 GO:0006465 signal peptide processing(GO:0006465)
0.2 1.0 GO:0035878 nail development(GO:0035878)
0.1 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 1.0 GO:0045116 protein neddylation(GO:0045116)
0.0 1.0 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.0 GO:0032543 mitochondrial translation(GO:0032543)
0.3 0.9 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.3 0.9 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
0.2 0.9 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1 0.9 GO:0036506 maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.9 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.2 0.8 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.9 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 1.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 1.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 1.2 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 1.1 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.0 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 1.0 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 1.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.9 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.9 GO:0008278 cohesin complex(GO:0008278)
0.1 0.9 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.8 GO:0005687 U4 snRNP(GO:0005687)
0.1 0.8 GO:0000243 commitment complex(GO:0000243)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.7 GO:0000125 PCAF complex(GO:0000125)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 1.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 1.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.3 1.3 GO:0004814 arginine-tRNA ligase activity(GO:0004814) arginine binding(GO:0034618)
0.2 1.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 1.2 GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769)
0.0 1.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 1.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 1.0 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.2 0.9 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 0.9 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.9 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.9 GO:0005158 insulin receptor binding(GO:0005158)
0.1 0.8 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.8 GO:0019788 NEDD8 transferase activity(GO:0019788)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 1.8 PID_MYC_PATHWAY C-MYC pathway
0.0 1.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 1.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.3 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.5 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 2.3 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 2.0 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.8 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.3 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 1.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.9 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.9 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 0.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.7 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening