Motif ID: Hoxc10

Z-value: 0.928


Transcription factors associated with Hoxc10:

Gene SymbolEntrez IDGene Name
Hoxc10 ENSMUSG00000022484.7 Hoxc10



Activity profile for motif Hoxc10.

activity profile for motif Hoxc10


Sorted Z-values histogram for motif Hoxc10

Sorted Z-values for motif Hoxc10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxc10

PNG image of the network

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Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_159737510 7.093 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_+_117841839 4.394 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr7_-_73537621 3.627 ENSMUST00000172704.1
 Chd2
chromodomain helicase DNA binding protein 2
chr16_-_23988852 2.882 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr15_+_21111452 2.848 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr6_-_13839916 2.605 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr1_-_69108039 2.409 ENSMUST00000121473.1
 Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr15_+_92597104 2.317 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr13_-_84064772 2.147 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144893127 2.131 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr11_-_79504078 2.041 ENSMUST00000164465.2
 Omg
oligodendrocyte myelin glycoprotein
chr15_-_58214882 1.977 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr1_+_66386968 1.929 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr15_+_81936911 1.718 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr2_-_144527341 1.692 ENSMUST00000163701.1
ENSMUST00000081982.5
 Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr2_-_36104060 1.646 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr11_+_29463735 1.622 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr15_+_81936753 1.597 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_100761741 1.578 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr9_-_44799179 1.383 ENSMUST00000114705.1
ENSMUST00000002100.7
 Tmem25

transmembrane protein 25


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 7.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
1.5 4.4 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 3.6 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 3.3 GO:0043488 regulation of mRNA stability(GO:0043488)
0.1 3.2 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
1.0 2.9 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.5 2.4 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.5 2.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 2.1 GO:0042572 retinol metabolic process(GO:0042572)
0.7 2.0 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.2 1.9 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.4 1.8 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.3 1.6 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.3 1.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.6 GO:0051453 regulation of intracellular pH(GO:0051453)
0.1 1.4 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 1.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.3 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 1.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 1.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 7.1 GO:0072534 perineuronal net(GO:0072534)
0.4 4.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 2.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 2.9 GO:0005657 replication fork(GO:0005657)
0.0 2.8 GO:0042641 actomyosin(GO:0042641)
0.0 2.7 GO:0005901 caveola(GO:0005901)
0.0 2.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.3 1.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.8 GO:0016459 myosin complex(GO:0016459)
0.2 0.5 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.1 GO:0046625 sphingolipid binding(GO:0046625)
1.5 4.4 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 3.6 GO:0004386 helicase activity(GO:0004386)
0.0 3.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 2.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 2.9 GO:0000287 magnesium ion binding(GO:0000287)
0.0 2.6 GO:0005057 receptor signaling protein activity(GO:0005057)
0.6 2.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.5 2.4 GO:0038132 neuregulin binding(GO:0038132)
0.3 2.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 1.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 1.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.6 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1 1.2 GO:0002162 dystroglycan binding(GO:0002162)
0.3 1.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.0 1.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 3.4 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 3.2 PID_CDC42_PATHWAY CDC42 signaling events
0.2 2.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.9 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.8 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 PID_GLYPICAN_1PATHWAY Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.4 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 2.0 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.6 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 0.7 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 0.6 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion