Motif ID: Hmga2

Z-value: 1.242


Transcription factors associated with Hmga2:

Gene SymbolEntrez IDGene Name
Hmga2 ENSMUSG00000056758.8 Hmga2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga2mm10_v2_chr10_-_120476469_1204765270.331.8e-01Click!


Activity profile for motif Hmga2.

activity profile for motif Hmga2


Sorted Z-values histogram for motif Hmga2

Sorted Z-values for motif Hmga2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga2

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_19418930 7.666 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3013140 7.589 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr2_-_98667264 7.333 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3004457 6.745 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3025417 5.341 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3023547 5.242 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3018753 4.932 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3017408 4.130 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr16_+_30065333 1.232 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr3_+_53845086 1.169 ENSMUST00000108014.1
 Gm10985
predicted gene 10985
chr7_-_5413145 0.897 ENSMUST00000108569.2
 Vmn1r58
vomeronasal 1 receptor 58
chr14_+_25980039 0.880 ENSMUST00000173155.1
 Duxbl1
double homeobox B-like 1
chr9_+_17030045 0.781 ENSMUST00000164523.2
 Gm5611
predicted gene 5611
chr17_+_40811089 0.770 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr1_+_172698046 0.752 ENSMUST00000038495.3
 Crp
C-reactive protein, pentraxin-related
chr3_+_88214474 0.746 ENSMUST00000181356.1
ENSMUST00000181396.1
 Gm3764

predicted gene 3764

chrM_+_9452 0.744 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr13_-_62607499 0.734 ENSMUST00000091563.4
 6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr17_+_36958623 0.723 ENSMUST00000173814.1
 Znrd1as
Znrd1 antisense
chr1_-_144004142 0.722 ENSMUST00000127206.1
 Rgs2
regulator of G-protein signaling 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.2 GO:0021557 oculomotor nerve development(GO:0021557)
0.0 0.9 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.3 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.8 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.1 0.7 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.2 0.6 GO:0016598 protein arginylation(GO:0016598)
0.0 0.6 GO:0006825 copper ion transport(GO:0006825)
0.0 0.6 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 0.5 GO:1902071 regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.1 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.5 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.5 GO:0031100 organ regeneration(GO:0031100)
0.0 0.5 GO:0006625 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.1 0.4 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.4 GO:2000427 eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.4 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
0.1 0.4 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.4 GO:0044299 C-fiber(GO:0044299)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.3 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 0.3 GO:0097546 ciliary base(GO:0097546)
0.1 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.8 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.8 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0 0.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.6 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.5 GO:0071568 UFM1 transferase activity(GO:0071568)
0.1 0.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.4 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.4 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.4 GO:0042936 dipeptide transporter activity(GO:0042936)
0.1 0.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.4 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.4 GO:0005537 mannose binding(GO:0005537)
0.1 0.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.3 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.2 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.8 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 0.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.8 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.4 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway