Motif ID: Zbtb6

Z-value: 0.593


Transcription factors associated with Zbtb6:

Gene SymbolEntrez IDGene Name
Zbtb6 ENSMUSG00000066798.3 Zbtb6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb6mm10_v2_chr2_-_37443096_374431780.581.2e-02Click!


Activity profile for motif Zbtb6.

activity profile for motif Zbtb6


Sorted Z-values histogram for motif Zbtb6

Sorted Z-values for motif Zbtb6



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb6

PNG image of the network

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Top targets:


Showing 1 to 20 of 199 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_133131782 1.419 ENSMUST00000180528.1
 Gm26616
predicted gene, 26616
chr17_-_17624458 1.239 ENSMUST00000041047.2
 Lnpep
leucyl/cystinyl aminopeptidase
chr6_+_114131229 1.129 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr11_-_102897123 1.112 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr3_+_54156039 1.080 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr4_+_136286061 0.904 ENSMUST00000069195.4
ENSMUST00000130658.1
 Zfp46

zinc finger protein 46

chr17_-_46487641 0.881 ENSMUST00000047034.8
 Ttbk1
tau tubulin kinase 1
chr11_-_114066174 0.857 ENSMUST00000041627.7
 Sdk2
sidekick homolog 2 (chicken)
chr7_-_105787544 0.855 ENSMUST00000078482.5
ENSMUST00000154659.1
 Dchs1

dachsous 1 (Drosophila)

chr1_+_75549581 0.772 ENSMUST00000154101.1
 Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr9_+_44499126 0.769 ENSMUST00000074989.5
 Bcl9l
B cell CLL/lymphoma 9-like
chr11_-_30025915 0.752 ENSMUST00000058902.5
 Eml6
echinoderm microtubule associated protein like 6
chr9_+_108826320 0.740 ENSMUST00000024238.5
 Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr4_+_107802277 0.724 ENSMUST00000106733.2
ENSMUST00000030356.3
ENSMUST00000106732.2
ENSMUST00000126573.1
 Lrp8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr4_-_141538434 0.722 ENSMUST00000078886.3
 Spen
SPEN homolog, transcriptional regulator (Drosophila)
chr7_+_105375053 0.721 ENSMUST00000106805.2
 Gm5901
predicted gene 5901
chr16_-_17405877 0.675 ENSMUST00000154364.1
 Pi4ka
phosphatidylinositol 4-kinase, catalytic, alpha polypeptide
chr16_-_45158624 0.672 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr11_-_102897146 0.662 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr18_+_37513652 0.662 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.8 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.0 1.6 GO:0051453 regulation of intracellular pH(GO:0051453)
0.3 1.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.2 1.3 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 1.2 GO:0043171 peptide catabolic process(GO:0043171)
0.1 1.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.1 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.1 1.0 GO:0007379 segment specification(GO:0007379)
0.2 0.9 GO:0009414 response to water deprivation(GO:0009414)
0.1 0.9 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.3 0.8 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.2 0.7 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.7 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 0.7 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.7 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 0.7 GO:1902476 chloride transmembrane transport(GO:1902476)
0.2 0.6 GO:0006601 creatine biosynthetic process(GO:0006601)
0.2 0.6 GO:0045358 negative regulation of interferon-beta biosynthetic process(GO:0045358)
0.1 0.6 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 1.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 1.5 GO:0005901 caveola(GO:0005901)
0.0 0.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.8 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.8 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.2 0.7 GO:0019034 viral replication complex(GO:0019034)
0.1 0.6 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.5 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.4 GO:0042581 specific granule(GO:0042581)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.3 GO:1904115 axon cytoplasm(GO:1904115)
0.1 0.2 GO:0055087 Ski complex(GO:0055087)
0.0 0.2 GO:1990393 3M complex(GO:1990393)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 1.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 1.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 1.1 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 0.7 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.7 GO:0070728 leucine binding(GO:0070728)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.6 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.6 GO:0043426 MRF binding(GO:0043426)
0.1 0.6 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 0.5 GO:0097643 amylin receptor activity(GO:0097643)
0.1 0.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.8 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.2 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.2 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.4 1.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.1 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.0 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 0.8 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.7 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.7 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.3 REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.0 0.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA