Motif ID: Zbtb6
Z-value: 0.593
Transcription factors associated with Zbtb6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Zbtb6 | ENSMUSG00000066798.3 | Zbtb6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Zbtb6 | mm10_v2_chr2_-_37443096_37443178 | 0.58 | 1.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.3 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.3 | 1.8 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
0.3 | 0.8 | GO:0021837 | motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465) |
0.2 | 0.9 | GO:0009414 | response to water deprivation(GO:0009414) |
0.2 | 1.3 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
0.2 | 0.6 | GO:0006601 | creatine biosynthetic process(GO:0006601) |
0.2 | 0.5 | GO:1903348 | positive regulation of bicellular tight junction assembly(GO:1903348) |
0.2 | 0.7 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
0.2 | 0.6 | GO:0045358 | negative regulation of interferon-beta biosynthetic process(GO:0045358) |
0.2 | 0.5 | GO:1902630 | regulation of membrane hyperpolarization(GO:1902630) |
0.1 | 0.4 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
0.1 | 0.4 | GO:0030070 | insulin processing(GO:0030070) |
0.1 | 0.7 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
0.1 | 0.3 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
0.1 | 0.3 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
0.1 | 0.4 | GO:1904778 | regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
0.1 | 1.1 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.1 | 0.4 | GO:0035937 | estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864) |
0.1 | 0.5 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
0.1 | 0.3 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
0.1 | 0.4 | GO:0016240 | autophagosome docking(GO:0016240) |
0.1 | 0.5 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
0.1 | 0.5 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
0.1 | 0.3 | GO:0097026 | dendritic cell dendrite assembly(GO:0097026) |
0.1 | 0.2 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 0.7 | GO:0038026 | reelin-mediated signaling pathway(GO:0038026) |
0.1 | 0.3 | GO:0060744 | thelarche(GO:0042695) positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) mammary gland branching involved in thelarche(GO:0060744) mammary gland branching involved in pregnancy(GO:0060745) positive regulation of G0 to G1 transition(GO:0070318) |
0.1 | 0.4 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
0.1 | 0.5 | GO:0036006 | response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006) |
0.1 | 0.4 | GO:0048840 | otolith development(GO:0048840) |
0.1 | 0.2 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) |
0.1 | 0.6 | GO:0071420 | cellular response to histamine(GO:0071420) |
0.1 | 0.2 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
0.1 | 0.3 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
0.1 | 1.1 | GO:0014051 | gamma-aminobutyric acid secretion(GO:0014051) |
0.1 | 1.0 | GO:0007379 | segment specification(GO:0007379) |
0.1 | 0.5 | GO:0097151 | spontaneous neurotransmitter secretion(GO:0061669) positive regulation of inhibitory postsynaptic potential(GO:0097151) spontaneous synaptic transmission(GO:0098814) |
0.1 | 0.3 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
0.1 | 0.9 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
0.0 | 0.2 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
0.0 | 0.5 | GO:0070995 | toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995) |
0.0 | 0.6 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
0.0 | 1.2 | GO:0043171 | peptide catabolic process(GO:0043171) |
0.0 | 0.1 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
0.0 | 0.1 | GO:0019372 | lipoxygenase pathway(GO:0019372) |
0.0 | 0.7 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
0.0 | 0.3 | GO:0070874 | negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874) |
0.0 | 0.5 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
0.0 | 0.1 | GO:0060763 | mammary duct terminal end bud growth(GO:0060763) |
0.0 | 0.4 | GO:0099628 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628) |
0.0 | 0.1 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) cerebellum vasculature development(GO:0061300) |
0.0 | 0.2 | GO:0016266 | O-glycan processing(GO:0016266) |
0.0 | 0.2 | GO:0034427 | nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427) |
0.0 | 0.3 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.0 | 0.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
0.0 | 0.5 | GO:0021702 | cerebellar Purkinje cell differentiation(GO:0021702) |
0.0 | 0.2 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
0.0 | 1.6 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
0.0 | 0.2 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
0.0 | 0.7 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
0.0 | 0.6 | GO:0030318 | melanocyte differentiation(GO:0030318) |
0.0 | 0.1 | GO:0050908 | detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962) |
0.0 | 0.2 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
0.0 | 0.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
0.0 | 0.2 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
0.0 | 0.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.0 | 0.1 | GO:0032382 | positive regulation of intracellular lipid transport(GO:0032379) positive regulation of intracellular sterol transport(GO:0032382) positive regulation of intracellular cholesterol transport(GO:0032385) lipid hydroperoxide transport(GO:1901373) |
0.0 | 0.1 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
0.0 | 0.1 | GO:0070475 | rRNA base methylation(GO:0070475) |
0.0 | 0.5 | GO:0010591 | regulation of lamellipodium assembly(GO:0010591) |
0.0 | 0.1 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
0.0 | 0.9 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
0.0 | 0.2 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
0.0 | 0.1 | GO:0071625 | vocalization behavior(GO:0071625) |
0.0 | 0.4 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
0.0 | 0.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.8 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.2 | 0.7 | GO:0019034 | viral replication complex(GO:0019034) |
0.1 | 0.6 | GO:0031084 | BLOC-2 complex(GO:0031084) |
0.1 | 0.4 | GO:0020018 | ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018) |
0.1 | 0.5 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
0.1 | 0.2 | GO:0055087 | Ski complex(GO:0055087) |
0.0 | 0.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.0 | 0.3 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
0.0 | 0.6 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.0 | 0.4 | GO:0042581 | specific granule(GO:0042581) |
0.0 | 0.8 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
0.0 | 0.2 | GO:1990393 | 3M complex(GO:1990393) |
0.0 | 0.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 0.8 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
0.0 | 0.3 | GO:0043196 | varicosity(GO:0043196) |
0.0 | 0.2 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
0.0 | 0.5 | GO:0060077 | inhibitory synapse(GO:0060077) |
0.0 | 0.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.0 | 0.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.0 | 0.1 | GO:0071141 | SMAD protein complex(GO:0071141) |
0.0 | 0.1 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
0.0 | 1.5 | GO:0005901 | caveola(GO:0005901) |
0.0 | 2.9 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.0 | 0.2 | GO:0030061 | mitochondrial crista(GO:0030061) |
0.0 | 0.2 | GO:0016514 | SWI/SNF complex(GO:0016514) |
0.0 | 0.4 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
0.0 | 0.2 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.1 | GO:0005332 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) |
0.2 | 0.7 | GO:0038025 | reelin receptor activity(GO:0038025) |
0.1 | 0.6 | GO:0072345 | NAADP-sensitive calcium-release channel activity(GO:0072345) |
0.1 | 1.1 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.1 | 0.4 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
0.1 | 0.7 | GO:0070728 | leucine binding(GO:0070728) |
0.1 | 0.5 | GO:0097643 | amylin receptor activity(GO:0097643) |
0.1 | 0.6 | GO:0043426 | MRF binding(GO:0043426) |
0.1 | 0.4 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
0.1 | 0.5 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
0.1 | 0.5 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.1 | 0.6 | GO:1904315 | GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
0.1 | 1.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
0.1 | 1.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.1 | 0.8 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
0.1 | 1.9 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.1 | 0.3 | GO:0036033 | mediator complex binding(GO:0036033) |
0.1 | 0.5 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
0.1 | 0.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
0.1 | 0.5 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
0.1 | 0.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
0.1 | 1.2 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
0.0 | 0.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.3 | GO:0097016 | L27 domain binding(GO:0097016) |
0.0 | 0.1 | GO:0035500 | MH2 domain binding(GO:0035500) |
0.0 | 0.4 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
0.0 | 0.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.0 | 0.1 | GO:0008988 | rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) U6 snRNA 3'-end binding(GO:0030629) |
0.0 | 0.5 | GO:0001618 | virus receptor activity(GO:0001618) |
0.0 | 0.3 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 0.2 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
0.0 | 0.2 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.0 | 1.3 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.0 | 0.4 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
0.0 | 0.3 | GO:0008227 | G-protein coupled amine receptor activity(GO:0008227) |
0.0 | 0.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.0 | 0.2 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
0.0 | 0.2 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
0.0 | 0.2 | GO:0048495 | GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495) |
0.0 | 1.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.3 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
0.0 | 0.2 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
0.0 | 0.6 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
0.0 | 0.1 | GO:0004065 | arylsulfatase activity(GO:0004065) |
0.0 | 0.1 | GO:0050632 | propanoyl-CoA C-acyltransferase activity(GO:0033814) propionyl-CoA C2-trimethyltridecanoyltransferase activity(GO:0050632) phosphatidylethanolamine transporter activity(GO:1904121) |
0.0 | 0.2 | GO:0031386 | protein tag(GO:0031386) |
0.0 | 0.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.2 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
0.0 | 0.9 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
0.0 | 1.3 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
0.0 | 0.8 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
0.0 | 0.2 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
0.0 | 0.8 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.0 | 0.5 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
0.0 | 0.2 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
0.0 | 0.3 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.2 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.1 | 1.0 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
0.1 | 1.1 | REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
0.1 | 0.8 | REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
0.1 | 1.0 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
0.0 | 1.8 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.0 | 0.7 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
0.0 | 0.7 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
0.0 | 0.4 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
0.0 | 0.6 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.0 | 0.4 | REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
0.0 | 2.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 0.3 | REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
0.0 | 0.3 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
0.0 | 0.3 | REACTOME_AMINE_LIGAND_BINDING_RECEPTORS | Genes involved in Amine ligand-binding receptors |
0.0 | 0.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 0.5 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
0.0 | 0.3 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
0.0 | 0.3 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
0.0 | 0.3 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.0 | 0.2 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
0.0 | 0.2 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
0.0 | 0.1 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |