Motif ID: Hoxb2_Dlx2

Z-value: 0.627

Transcription factors associated with Hoxb2_Dlx2:

Gene SymbolEntrez IDGene Name
Dlx2 ENSMUSG00000023391.7 Dlx2
Hoxb2 ENSMUSG00000075588.5 Hoxb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx2mm10_v2_chr2_-_71546745_715467580.681.9e-03Click!


Activity profile for motif Hoxb2_Dlx2.

activity profile for motif Hoxb2_Dlx2


Sorted Z-values histogram for motif Hoxb2_Dlx2

Sorted Z-values for motif Hoxb2_Dlx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb2_Dlx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 4.010 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_48665098 2.203 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr7_+_144838590 1.589 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr6_-_23248264 1.443 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr13_-_102906046 1.339 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 1.306 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr2_+_71528657 1.304 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr5_-_87482258 1.200 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr19_-_59170978 1.081 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr3_-_154328634 1.080 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr2_-_71546745 1.041 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr12_+_38783503 1.015 ENSMUST00000159334.1
 Etv1
ets variant gene 1
chr1_-_190170671 1.009 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr12_+_38780284 0.989 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr15_+_25773985 0.954 ENSMUST00000125667.1
 Myo10
myosin X
chr12_+_38780817 0.907 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_-_154330543 0.868 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr6_+_4755327 0.862 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr4_+_8690399 0.844 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr14_-_70642268 0.833 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 3.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.7 2.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 2.3 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.3 2.2 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 1.8 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.5 1.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.3 1.4 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 1.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 1.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.1 0.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.9 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.3 0.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 0.8 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.2 0.7 GO:0060166 olfactory pit development(GO:0060166)
0.1 0.7 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.7 GO:0010587 miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.6 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.5 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.5 GO:0031523 Myb complex(GO:0031523)
0.0 0.5 GO:0005915 zonula adherens(GO:0005915)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.5 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0060187 cell pole(GO:0060187)
0.0 0.4 GO:0000776 kinetochore(GO:0000776)
0.0 0.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.3 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.3 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.2 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 2.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.6 GO:0050693 LBD domain binding(GO:0050693)
0.3 1.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.1 0.9 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 0.9 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 0.8 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 0.7 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.7 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.6 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.5 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.5 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.2 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.1 PID_MYC_PATHWAY C-MYC pathway
0.0 0.1 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.1 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.4 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 1.2 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.9 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.3 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.1 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen