Motif ID: Neurod1

Z-value: 0.736


Transcription factors associated with Neurod1:

Gene SymbolEntrez IDGene Name
Neurod1 ENSMUSG00000034701.9 Neurod1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Neurod1mm10_v2_chr2_-_79456750_794567610.292.5e-01Click!


Activity profile for motif Neurod1.

activity profile for motif Neurod1


Sorted Z-values histogram for motif Neurod1

Sorted Z-values for motif Neurod1



Network of associatons between targets according to the STRING database.



First level regulatory network of Neurod1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_42907563 3.195 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr10_+_69706326 2.313 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr6_-_136171722 2.229 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr17_-_6449571 2.172 ENSMUST00000180035.1
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr9_+_46998931 2.171 ENSMUST00000178065.1
 Gm4791
predicted gene 4791
chr11_-_107915041 2.003 ENSMUST00000039071.2
 Cacng5
calcium channel, voltage-dependent, gamma subunit 5
chr12_+_29528382 1.704 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr2_-_25319095 1.690 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr4_-_22488296 1.350 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr5_+_3343893 1.348 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr16_-_67620880 1.317 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr10_-_110000219 1.286 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr6_+_54681687 1.279 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr18_-_89769479 1.261 ENSMUST00000097495.3
 Dok6
docking protein 6
chr11_+_70030023 1.224 ENSMUST00000143920.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr10_+_127759721 1.187 ENSMUST00000073639.5
 Rdh1
retinol dehydrogenase 1 (all trans)
chr6_-_121081589 1.145 ENSMUST00000077159.5
 Mical3
microtubule associated monooxygenase, calponin and LIM domain containing 3
chr2_-_52335134 1.144 ENSMUST00000075301.3
 Neb
nebulin
chr3_-_84259812 1.120 ENSMUST00000107691.1
 Trim2
tripartite motif-containing 2
chr17_-_6621267 1.112 ENSMUST00000115772.3
 Tmem181c-ps
transmembrane protein 181C, pseudogene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 2.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.6 2.2 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.7 2.1 GO:1900673 olefin metabolic process(GO:1900673)
0.1 2.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 1.9 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 1.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.7 GO:0048665 neuron fate specification(GO:0048665)
0.2 1.3 GO:0044838 cell quiescence(GO:0044838)
0.1 1.3 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 1.2 GO:0001523 retinoid metabolic process(GO:0001523)
0.0 1.2 GO:0030042 actin filament depolymerization(GO:0030042)
0.0 1.2 GO:0002028 regulation of sodium ion transport(GO:0002028)
0.1 1.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.1 1.1 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.2 1.0 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 1.0 GO:0030035 microspike assembly(GO:0030035)
0.1 1.0 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 0.9 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.2 0.9 GO:0006543 glutamine catabolic process(GO:0006543)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 2.6 GO:0001726 ruffle(GO:0001726)
0.1 2.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 2.1 GO:0044307 dendritic branch(GO:0044307)
0.1 2.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.9 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.1 GO:0030667 secretory granule membrane(GO:0030667)
0.3 1.0 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.0 GO:0030175 filopodium(GO:0030175)
0.0 1.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.9 GO:0055037 recycling endosome(GO:0055037)
0.0 0.9 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 0.8 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.7 GO:0070419 nonhomologous end joining complex(GO:0070419)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.0 3.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 3.1 GO:0030507 spectrin binding(GO:0030507)
0.1 2.6 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 1.9 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 1.6 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 1.3 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 1.3 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 1.2 GO:0005178 integrin binding(GO:0005178)
0.1 1.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.1 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.2 1.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 0.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 0.9 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.9 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 1.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 1.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.7 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.7 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 0.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 1.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 0.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.8 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.8 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation