Motif ID: Foxp2_Foxp3

Z-value: 0.639

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_14901440_149014970.625.6e-03Click!
Foxp3mm10_v2_chrX_+_7579666_75796930.019.7e-01Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 3.295 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr4_+_144892813 2.596 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr11_+_3332426 2.479 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr6_-_148444336 2.445 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr1_+_66386968 2.356 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr6_+_135362931 2.296 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr6_+_141524379 2.273 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr1_+_34005872 2.220 ENSMUST00000182296.1
 Dst
dystonin
chr5_+_3928033 2.053 ENSMUST00000143365.1
 Akap9
A kinase (PRKA) anchor protein (yotiao) 9
chr2_+_28641227 1.997 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
 Tsc1


tuberous sclerosis 1


chr4_+_144893077 1.861 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_60106452 1.819 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr6_-_39725193 1.790 ENSMUST00000101497.3
 Braf
Braf transforming gene
chr4_+_144893127 1.639 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr2_-_7395879 1.579 ENSMUST00000182404.1
 Celf2
CUGBP, Elav-like family member 2
chr4_-_87806296 1.532 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr8_-_84773381 1.520 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr12_-_100725028 1.508 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr11_+_69095217 1.498 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr15_-_58214882 1.491 ENSMUST00000022986.6
 Fbxo32
F-box protein 32

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.1 GO:0042572 retinol metabolic process(GO:0042572)
0.5 3.4 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 3.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 3.3 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 3.3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 3.2 GO:0031280 negative regulation of cyclase activity(GO:0031280)
0.1 2.8 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 2.7 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 2.6 GO:0070842 aggresome assembly(GO:0070842)
0.3 2.5 GO:0060137 maternal process involved in parturition(GO:0060137)
0.2 2.4 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 2.3 GO:0032060 bleb assembly(GO:0032060)
0.1 2.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 2.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 2.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 2.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.7 2.0 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.2 2.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.2 1.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.8 GO:0042118 endothelial cell activation(GO:0042118)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 5.5 GO:0014069 postsynaptic density(GO:0014069)
0.1 3.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 3.2 GO:0044307 dendritic branch(GO:0044307)
0.7 2.7 GO:0031673 H zone(GO:0031673)
0.0 2.7 GO:0016605 PML body(GO:0016605)
0.3 2.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 2.2 GO:0031941 filamentous actin(GO:0031941)
0.1 2.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.7 2.0 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 2.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.4 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.3 GO:0030057 desmosome(GO:0030057)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.0 1.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 3.6 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.1 3.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.1 2.6 GO:0042287 MHC protein binding(GO:0042287)
0.3 2.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 2.3 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 2.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 2.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 2.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 1.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.8 GO:0031402 sodium ion binding(GO:0031402)
0.2 1.7 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 1.7 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.5 1.5 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 1.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.1 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.1 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 2.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 2.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 2.3 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 2.2 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 1.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 1.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 1.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 1.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS Genes involved in Post NMDA receptor activation events
0.1 3.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 2.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 2.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 2.0 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 1.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.4 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 1.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.1 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 0.7 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 0.7 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 0.6 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation