Motif ID: Thra

Z-value: 0.760


Transcription factors associated with Thra:

Gene SymbolEntrez IDGene Name
Thra ENSMUSG00000058756.7 Thra

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Thramm10_v2_chr11_+_98741805_98741816-0.735.8e-04Click!


Activity profile for motif Thra.

activity profile for motif Thra


Sorted Z-values histogram for motif Thra

Sorted Z-values for motif Thra



Network of associatons between targets according to the STRING database.



First level regulatory network of Thra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_116422858 2.555 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr18_+_57142782 2.154 ENSMUST00000139892.1
 Megf10
multiple EGF-like-domains 10
chr13_+_44729794 1.822 ENSMUST00000172830.1
 Jarid2
jumonji, AT rich interactive domain 2
chr4_+_44300876 1.563 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr1_+_84839833 1.523 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr14_-_118052235 1.404 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr10_-_92162753 1.381 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr4_-_137766474 1.322 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr17_-_32388885 1.107 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr12_+_79029150 1.061 ENSMUST00000039928.5
 Plekhh1
pleckstrin homology domain containing, family H (with MyTH4 domain) member 1
chr12_+_112678803 1.025 ENSMUST00000174780.1
ENSMUST00000169593.1
ENSMUST00000173942.1
 Zbtb42


zinc finger and BTB domain containing 42


chr14_-_118706180 1.016 ENSMUST00000036554.6
ENSMUST00000166646.1
 Abcc4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr4_-_135272798 0.920 ENSMUST00000037099.8
 Clic4
chloride intracellular channel 4 (mitochondrial)
chr11_+_69965396 0.906 ENSMUST00000018713.6
 Cldn7
claudin 7
chr6_+_113531675 0.883 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr1_-_84839304 0.882 ENSMUST00000027421.6
 Trip12
thyroid hormone receptor interactor 12
chr6_+_120836201 0.881 ENSMUST00000009256.2
 Bcl2l13
BCL2-like 13 (apoptosis facilitator)
chr11_+_40733936 0.843 ENSMUST00000127382.1
 Nudcd2
NudC domain containing 2
chrX_-_143827391 0.840 ENSMUST00000087316.5
 Capn6
calpain 6
chr1_-_163994767 0.837 ENSMUST00000097493.3
ENSMUST00000045876.6
 BC055324

cDNA sequence BC055324


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.4 2.2 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.0 2.2 GO:0006457 protein folding(GO:0006457)
0.3 1.8 GO:0007296 vitellogenesis(GO:0007296)
0.0 1.6 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.2 1.4 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 1.3 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.2 1.3 GO:0008343 adult feeding behavior(GO:0008343)
0.0 1.3 GO:0046677 endochondral ossification(GO:0001958) replacement ossification(GO:0036075) response to antibiotic(GO:0046677)
0.1 1.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.3 1.0 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 1.0 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 1.0 GO:0051639 actin filament network formation(GO:0051639)
0.3 0.9 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 0.9 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.9 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.9 GO:0032463 negative regulation of protein homooligomerization(GO:0032463)
0.0 0.9 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 0.8 GO:0019046 release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382)
0.3 0.8 GO:0097402 neuroblast migration(GO:0097402)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 2.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.6 GO:0000776 kinetochore(GO:0000776)
0.1 1.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 1.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 1.1 GO:0005776 autophagosome(GO:0005776)
0.3 1.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 1.0 GO:0042587 glycogen granule(GO:0042587)
0.0 1.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 0.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.8 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 2.4 GO:0051082 unfolded protein binding(GO:0051082)
0.3 2.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 1.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 1.4 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 1.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 1.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 1.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.9 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.9 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 0.8 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.8 GO:0043495 protein anchor(GO:0043495)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 0.7 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.7 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.6 GO:0017166 vinculin binding(GO:0017166)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.5 PID_ATM_PATHWAY ATM pathway
0.0 1.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.1 0.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.5 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.4 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.5 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 1.2 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.2 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.0 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.0 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 0.9 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 0.8 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 0.7 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 0.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.4 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1