Motif ID: Nkx2-2

Z-value: 1.911


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_1471864130.175.0e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3018753 7.434 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr14_-_19418930 7.032 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3034599 6.626 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3025417 6.191 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3005125 5.780 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3015654 5.765 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 5.434 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr3_+_118433797 3.876 ENSMUST00000180593.1
ENSMUST00000181926.1
ENSMUST00000181060.1
ENSMUST00000181310.1
 Gm26871



predicted gene, 26871



chrX_+_9885622 3.543 ENSMUST00000067529.2
ENSMUST00000086165.3
 Sytl5

synaptotagmin-like 5

chr10_+_88091070 3.180 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr10_-_33995054 3.153 ENSMUST00000164429.1
 Gm17567
predicted gene, 17567
chr19_-_5796924 3.142 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr3_+_5218516 2.443 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr5_-_123141067 2.124 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chr5_-_123140135 2.045 ENSMUST00000160099.1
 AI480526
expressed sequence AI480526
chr1_-_166002613 1.971 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr6_+_5390387 1.751 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr15_-_10470490 1.513 ENSMUST00000136591.1
 Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr10_+_93897156 1.496 ENSMUST00000180815.1
 4930471D02Rik
RIKEN cDNA 4930471D02 gene
chr4_+_115563649 1.494 ENSMUST00000141033.1
ENSMUST00000030486.8
ENSMUST00000126645.1
ENSMUST00000030480.3
 Cyp4a31



cytochrome P450, family 4, subfamily a, polypeptide 31




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 3.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.1 3.2 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.6 3.1 GO:0035063 nuclear speck organization(GO:0035063)
0.2 2.5 GO:0070986 left/right axis specification(GO:0070986)
0.3 2.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 2.0 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.6 1.9 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.2 1.8 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.1 1.3 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256) positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.4 1.2 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.3 1.2 GO:0090235 regulation of metaphase plate congression(GO:0090235)
0.1 1.2 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 1.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.2 GO:0007606 sensory perception of chemical stimulus(GO:0007606)
0.4 1.1 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.1 1.1 GO:0030035 microspike assembly(GO:0030035)
0.2 1.0 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 1.0 GO:0017156 calcium ion regulated exocytosis(GO:0017156)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)
0.0 2.6 GO:0072562 blood microparticle(GO:0072562)
0.0 2.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 1.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.4 1.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 1.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 1.3 GO:0072686 mitotic spindle(GO:0072686)
0.1 1.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.2 GO:0005902 microvillus(GO:0005902)
0.1 1.0 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.9 GO:0001940 male pronucleus(GO:0001940)
0.1 0.9 GO:0005922 connexon complex(GO:0005922)
0.1 0.8 GO:0070578 RISC-loading complex(GO:0070578)
0.1 0.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.8 GO:0070938 contractile ring(GO:0070938)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.2 0.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.0 0.7 GO:0030173 integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.8 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 3.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 3.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.3 2.0 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 2.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.9 GO:0001848 complement binding(GO:0001848)
0.5 1.5 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 1.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.4 1.1 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 1.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.0 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.9 GO:0019905 syntaxin binding(GO:0019905)
0.1 0.8 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.8 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.2 0.7 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.7 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.3 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 0.8 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.3 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.2 1.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.1 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism
0.0 1.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 0.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.2 0.8 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.8 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.7 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.3 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.3 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER