Motif ID: Mtf1

Z-value: 0.752


Transcription factors associated with Mtf1:

Gene SymbolEntrez IDGene Name
Mtf1 ENSMUSG00000028890.7 Mtf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mtf1mm10_v2_chr4_+_124802543_1248026780.253.2e-01Click!


Activity profile for motif Mtf1.

activity profile for motif Mtf1


Sorted Z-values histogram for motif Mtf1

Sorted Z-values for motif Mtf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mtf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 82 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_94172618 2.737 ENSMUST00000034214.6
 Mt2
metallothionein 2
chr11_-_32222233 2.376 ENSMUST00000150381.1
ENSMUST00000144902.1
ENSMUST00000020524.8
 Rhbdf1


rhomboid family 1 (Drosophila)


chr11_+_63133068 1.875 ENSMUST00000108700.1
 Pmp22
peripheral myelin protein 22
chr11_+_63132569 1.665 ENSMUST00000108701.1
 Pmp22
peripheral myelin protein 22
chr9_-_56635624 1.251 ENSMUST00000114256.1
 Lingo1
leucine rich repeat and Ig domain containing 1
chr5_+_105415738 0.964 ENSMUST00000112707.1
 Lrrc8b
leucine rich repeat containing 8 family, member B
chr9_-_112187898 0.898 ENSMUST00000178410.1
ENSMUST00000172380.3
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr7_-_43313063 0.892 ENSMUST00000135130.1
ENSMUST00000139061.1
 Zfp715

zinc finger protein 715

chr13_+_23934434 0.887 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr15_-_58214882 0.853 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr4_+_103619580 0.828 ENSMUST00000106827.1
 Dab1
disabled 1
chr17_-_83631892 0.778 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr8_+_94179089 0.714 ENSMUST00000034215.6
 Mt1
metallothionein 1
chr4_+_134496996 0.697 ENSMUST00000095074.3
 Paqr7
progestin and adipoQ receptor family member VII
chr1_+_135729147 0.688 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_-_166002613 0.610 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1



chr10_+_17723220 0.589 ENSMUST00000038107.7
 Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr13_-_45964964 0.585 ENSMUST00000180110.1
ENSMUST00000091628.3
ENSMUST00000167708.2
 Atxn1


ataxin 1


chr9_+_57940104 0.583 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr7_+_5056856 0.571 ENSMUST00000131368.1
ENSMUST00000123956.1
 Ccdc106

coiled-coil domain containing 106


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.2 3.5 GO:0032060 bleb assembly(GO:0032060)
0.0 2.4 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.1 1.3 GO:0048715 negative regulation of oligodendrocyte differentiation(GO:0048715)
0.2 1.1 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.3 0.9 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.9 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.0 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.3 0.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1 0.6 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.1 0.6 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.3 GO:0035844 positive regulation of polarized epithelial cell differentiation(GO:0030862) cloaca development(GO:0035844)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.2 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661) maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0043218 compact myelin(GO:0043218)
0.0 1.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 0.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.6 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.3 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0045098 type III intermediate filament(GO:0045098)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.0 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.8 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.8 GO:0005507 copper ion binding(GO:0005507)
0.1 0.6 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.6 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.0 0.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.0 GO:0034056 estrogen response element binding(GO:0034056)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.3 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.1 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.9 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.8 PID_REELIN_PATHWAY Reelin signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.9 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.1 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism