Motif ID: Tfap4

Z-value: 1.565


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_4559747-0.165.2e-01Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 10.563 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr15_-_66812593 9.244 ENSMUST00000100572.3
 Sla
src-like adaptor
chr9_-_40346290 7.928 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr4_+_119814495 6.815 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr6_-_136171722 6.270 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr4_+_48045144 5.485 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr7_-_120202104 5.299 ENSMUST00000033198.5
 Crym
crystallin, mu
chr2_-_52335134 5.135 ENSMUST00000075301.3
 Neb
nebulin
chr2_+_170731807 4.580 ENSMUST00000029075.4
 Dok5
docking protein 5
chr6_-_58907120 4.476 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr2_+_37516618 4.355 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr16_+_43510267 4.161 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr8_+_66386292 4.084 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr13_+_29014399 3.994 ENSMUST00000146336.1
ENSMUST00000130109.1
 A330102I10Rik

RIKEN cDNA A330102I10 gene

chr15_-_71727815 3.955 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr8_-_115707778 3.806 ENSMUST00000109104.1
 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr7_+_144284385 3.743 ENSMUST00000097929.2
 Shank2
SH3/ankyrin domain gene 2
chr18_-_23041641 3.303 ENSMUST00000097651.3
 Nol4
nucleolar protein 4
chr10_+_69785507 3.238 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr13_+_54949388 3.202 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.6 6.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 6.0 GO:0048663 neuron fate commitment(GO:0048663)
0.1 5.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
1.8 5.5 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.1 5.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.1 5.1 GO:0045214 sarcomere organization(GO:0045214)
0.2 4.7 GO:0071625 vocalization behavior(GO:0071625)
0.3 4.6 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 4.5 GO:0006334 nucleosome assembly(GO:0006334)
1.1 4.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 4.4 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.1 4.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 4.2 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.2 4.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.0 4.1 GO:0051592 response to calcium ion(GO:0051592)
0.1 4.0 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 3.8 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.4 3.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.3 3.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 7.5 GO:0005667 transcription factor complex(GO:0005667)
0.4 6.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 5.9 GO:0005802 trans-Golgi network(GO:0005802)
0.3 4.4 GO:1990635 proximal dendrite(GO:1990635)
0.2 4.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 4.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 3.7 GO:0005883 neurofilament(GO:0005883)
0.0 3.5 GO:0005770 late endosome(GO:0005770)
0.2 3.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 3.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 2.7 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 2.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.3 GO:0043197 dendritic spine(GO:0043197)
0.4 2.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 2.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 2.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.0 GO:0043679 axon terminus(GO:0043679)
0.5 1.8 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.3 1.8 GO:0071203 WASH complex(GO:0071203)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.8 6.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.6 5.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.3 5.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 5.1 GO:0005158 insulin receptor binding(GO:0005158)
0.1 4.8 GO:0001223 transcription coactivator binding(GO:0001223)
1.1 4.4 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.5 4.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.2 4.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.2 4.4 GO:0070064 proline-rich region binding(GO:0070064)
0.2 4.1 GO:0042287 MHC protein binding(GO:0042287)
0.0 3.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 3.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 3.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5 3.2 GO:0005042 netrin receptor activity(GO:0005042)
0.3 2.7 GO:0034046 poly(G) binding(GO:0034046)
0.0 2.6 GO:0061733 peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.5 2.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.2 2.3 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 5.9 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 5.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 4.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 3.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 2.2 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 1.8 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.5 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.3 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 0.9 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 4.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 3.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 3.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.8 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.1 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.1 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.0 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.9 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 0.8 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins