Motif ID: Six6

Z-value: 0.525


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_72939758-0.155.7e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 163 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 2.425 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr14_+_67234620 1.904 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr9_+_98422961 1.382 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr4_-_97584605 1.372 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_+_140607334 1.287 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_97584612 1.286 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr11_+_98412461 1.111 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr1_+_45311538 0.984 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr7_+_46847128 0.953 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr7_-_42578588 0.930 ENSMUST00000179470.1
 Gm21028
predicted gene, 21028
chr11_+_78324200 0.907 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr8_-_94918012 0.875 ENSMUST00000077955.5
 Ccdc102a
coiled-coil domain containing 102A
chr12_+_52097737 0.839 ENSMUST00000040090.9
 Nubpl
nucleotide binding protein-like
chrX_-_142966709 0.765 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr5_+_144244432 0.713 ENSMUST00000110695.1
 Bri3
brain protein I3
chr8_+_85026833 0.704 ENSMUST00000047281.8
 2310036O22Rik
RIKEN cDNA 2310036O22 gene
chr10_-_128180265 0.689 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr8_+_40423786 0.682 ENSMUST00000049389.4
ENSMUST00000128166.1
ENSMUST00000167766.1
 Zdhhc2


zinc finger, DHHC domain containing 2


chr8_+_84831522 0.667 ENSMUST00000036734.5
 Gadd45gip1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr19_-_53589067 0.650 ENSMUST00000095978.3
 Nutf2-ps1
nuclear transport factor 2, pseudogene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 1.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.3 1.4 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 1.4 GO:0007338 single fertilization(GO:0007338)
0.3 1.3 GO:0007386 compartment pattern specification(GO:0007386)
0.4 1.1 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.2 1.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 1.0 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 0.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.9 GO:0018345 protein palmitoylation(GO:0018345)
0.3 0.8 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.0 0.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 0.7 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.1 0.6 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 0.6 GO:0070236 positive regulation of immunoglobulin secretion(GO:0051024) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.6 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.6 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.2 0.5 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.5 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0043219 lateral loop(GO:0043219)
0.0 1.1 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 1.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.0 0.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.6 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.4 GO:0019841 retinol binding(GO:0019841)
0.4 1.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 1.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.4 1.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 0.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.6 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.6 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.0 0.6 GO:0035198 miRNA binding(GO:0035198)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 0.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.0 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.6 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.3 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling
0.0 1.0 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.0 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.9 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.8 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.7 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.1 0.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.3 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway