Motif ID: Trp53

Z-value: 1.276


Transcription factors associated with Trp53:

Gene SymbolEntrez IDGene Name
Trp53 ENSMUSG00000059552.7 Trp53

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Trp53mm10_v2_chr11_+_69580392_695804190.184.7e-01Click!


Activity profile for motif Trp53.

activity profile for motif Trp53


Sorted Z-values histogram for motif Trp53

Sorted Z-values for motif Trp53



Network of associatons between targets according to the STRING database.



First level regulatory network of Trp53

PNG image of the network

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Top targets:


Showing 1 to 20 of 157 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_29090969 6.187 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr15_-_98004695 4.888 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr10_+_56377300 4.832 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr15_-_98004634 4.467 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr5_-_116422858 3.790 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr14_+_73237891 2.964 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr9_+_45138437 2.905 ENSMUST00000060125.5
 Scn4b
sodium channel, type IV, beta
chr2_-_69206146 2.860 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr9_+_66946057 2.761 ENSMUST00000040917.7
ENSMUST00000127896.1
 Rps27l

ribosomal protein S27-like

chr17_-_33890584 2.760 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr14_-_34374617 2.635 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr2_-_69206133 2.508 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr1_+_6487231 2.483 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr4_+_116596672 2.358 ENSMUST00000051869.7
 Ccdc17
coiled-coil domain containing 17
chr4_-_135573623 2.351 ENSMUST00000105855.1
 Grhl3
grainyhead-like 3 (Drosophila)
chr17_-_33890539 2.307 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr9_-_106158109 2.261 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr9_-_100486788 2.257 ENSMUST00000098458.3
 Il20rb
interleukin 20 receptor beta
chr11_-_3527916 2.251 ENSMUST00000020718.4
 Smtn
smoothelin
chr8_-_22185758 2.178 ENSMUST00000046916.7
 Ckap2
cytoskeleton associated protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.7 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.8 6.2 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 5.4 GO:0007052 mitotic spindle organization(GO:0007052)
1.7 5.1 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
1.6 4.8 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.3 4.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.9 3.4 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.1 3.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 2.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 2.6 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.2 2.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.2 2.5 GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307)
0.8 2.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.2 2.4 GO:0061436 establishment of skin barrier(GO:0061436)
0.8 2.3 GO:0002865 immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.4 2.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 2.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.5 2.0 GO:0046073 dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.0 2.0 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.5 1.9 GO:0046294 formaldehyde catabolic process(GO:0046294)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 9.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
2.1 6.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 6.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 6.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.9 5.4 GO:0031262 Ndc80 complex(GO:0031262)
0.4 4.8 GO:0005916 fascia adherens(GO:0005916)
1.1 4.3 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 4.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 2.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.5 GO:0043679 axon terminus(GO:0043679)
0.8 2.4 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 1.9 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 1.8 GO:0042627 chylomicron(GO:0042627)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 1.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.3 GO:0005741 mitochondrial outer membrane(GO:0005741)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.4 GO:0042289 MHC class II protein binding(GO:0042289)
2.1 6.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.4 5.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
1.2 4.8 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.2 4.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 3.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.4 3.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 2.9 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.5 2.8 GO:0008494 translation activator activity(GO:0008494)
0.1 2.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.5 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 2.4 GO:0070888 E-box binding(GO:0070888)
0.1 2.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.4 2.2 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.3 2.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 2.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.1 2.0 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.6 1.9 GO:0018738 S-formylglutathione hydrolase activity(GO:0018738)
0.1 1.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.8 GO:0030371 translation repressor activity(GO:0030371)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.4 NABA_COLLAGENS Genes encoding collagen proteins
0.7 6.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 4.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.0 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 2.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 6.2 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 5.1 REACTOME_KINESINS Genes involved in Kinesins
0.1 5.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 4.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 4.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 3.2 REACTOME_LIPOPROTEIN_METABOLISM Genes involved in Lipoprotein metabolism
0.3 3.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 2.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.0 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.4 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates