Motif ID: Zfp148
Z-value: 1.388
Transcription factors associated with Zfp148:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zfp148 | ENSMUSG00000022811.10 | Zfp148 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp148 | mm10_v2_chr16_+_33380765_33380787 | 0.83 | 1.8e-05 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 9.2 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 1.3 | 8.1 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 1.0 | 3.0 | GO:1904978 | regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980) |
| 0.9 | 2.8 | GO:0032241 | positive regulation of nucleobase-containing compound transport(GO:0032241) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.9 | 2.7 | GO:0042939 | glutathione transport(GO:0034635) tripeptide transport(GO:0042939) |
| 0.8 | 5.4 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
| 0.8 | 3.8 | GO:0060178 | regulation of exocyst localization(GO:0060178) |
| 0.6 | 3.9 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.6 | 1.8 | GO:0071677 | positive regulation of mononuclear cell migration(GO:0071677) |
| 0.5 | 2.0 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.5 | 2.9 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.5 | 1.4 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.4 | 2.2 | GO:0046113 | nucleobase catabolic process(GO:0046113) |
| 0.4 | 1.3 | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) |
| 0.4 | 4.3 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.4 | 1.5 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
| 0.4 | 2.5 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.3 | 2.8 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.3 | 2.9 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.3 | 1.1 | GO:0097494 | positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) regulation of vesicle size(GO:0097494) |
| 0.3 | 1.4 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
| 0.3 | 1.6 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.3 | 1.3 | GO:0015817 | glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365) |
| 0.3 | 1.1 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.3 | 1.6 | GO:1902287 | trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.3 | 1.3 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.3 | 1.8 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.3 | 21.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 0.9 | GO:0015744 | succinate transport(GO:0015744) |
| 0.2 | 2.5 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.2 | 0.9 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.2 | 0.9 | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) |
| 0.2 | 0.7 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.2 | 1.0 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.2 | 1.0 | GO:0032226 | positive regulation of synaptic transmission, dopaminergic(GO:0032226) |
| 0.2 | 2.0 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.2 | 0.6 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.2 | 3.0 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.2 | 0.9 | GO:0051012 | microtubule sliding(GO:0051012) |
| 0.2 | 1.8 | GO:0098532 | liver regeneration(GO:0097421) histone H3-K27 trimethylation(GO:0098532) |
| 0.2 | 0.9 | GO:1902995 | apolipoprotein A-I-mediated signaling pathway(GO:0038027) regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.2 | 0.8 | GO:1904717 | positive regulation of synapse structural plasticity(GO:0051835) regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.2 | 0.8 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.2 | 0.5 | GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway(GO:0060158) |
| 0.1 | 0.4 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
| 0.1 | 2.6 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.1 | 0.6 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
| 0.1 | 1.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.1 | 1.2 | GO:0086036 | regulation of cardiac muscle cell membrane potential(GO:0086036) |
| 0.1 | 1.7 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.1 | 0.6 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.1 | 0.6 | GO:0090038 | negative regulation of protein kinase C signaling(GO:0090038) |
| 0.1 | 0.8 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.1 | 1.1 | GO:0035434 | copper ion transmembrane transport(GO:0035434) |
| 0.1 | 1.0 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.1 | 1.5 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 0.5 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.1 | 0.6 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
| 0.1 | 0.4 | GO:0002035 | brain renin-angiotensin system(GO:0002035) |
| 0.1 | 1.6 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.1 | 0.9 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 0.9 | GO:0030049 | muscle filament sliding(GO:0030049) |
| 0.1 | 0.8 | GO:0038203 | TORC2 signaling(GO:0038203) |
| 0.1 | 0.4 | GO:0001927 | exocyst assembly(GO:0001927) |
| 0.1 | 0.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 1.7 | GO:0036010 | protein localization to endosome(GO:0036010) |
| 0.1 | 0.1 | GO:1901630 | negative regulation of presynaptic membrane organization(GO:1901630) |
| 0.1 | 0.9 | GO:0033008 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.1 | 0.3 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.1 | 0.6 | GO:1900086 | positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086) |
| 0.1 | 0.5 | GO:0060346 | bone trabecula formation(GO:0060346) |
| 0.1 | 0.2 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.1 | 2.2 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.1 | 1.0 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 3.1 | GO:0021696 | cerebellar cortex morphogenesis(GO:0021696) |
| 0.1 | 0.4 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 2.3 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 1.1 | GO:0001553 | luteinization(GO:0001553) |
| 0.1 | 0.3 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.1 | 0.2 | GO:0009446 | putrescine biosynthetic process(GO:0009446) |
| 0.1 | 1.6 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.1 | 0.5 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.0 | 1.3 | GO:0095500 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.5 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.0 | 0.5 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.0 | 0.8 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 0.3 | GO:0002544 | chronic inflammatory response(GO:0002544) |
| 0.0 | 1.2 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 2.1 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.2 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.0 | 2.2 | GO:0019915 | lipid storage(GO:0019915) |
| 0.0 | 0.4 | GO:1902866 | negative regulation of excitatory postsynaptic potential(GO:0090394) regulation of retina development in camera-type eye(GO:1902866) |
| 0.0 | 0.5 | GO:0007183 | SMAD protein complex assembly(GO:0007183) |
| 0.0 | 0.5 | GO:0099515 | actin filament-based transport(GO:0099515) |
| 0.0 | 0.2 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.0 | 0.1 | GO:0018201 | peptidyl-glycine modification(GO:0018201) |
| 0.0 | 0.6 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.1 | GO:0002489 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) |
| 0.0 | 0.4 | GO:1901339 | regulation of store-operated calcium channel activity(GO:1901339) |
| 0.0 | 4.8 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.7 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.0 | 0.5 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.0 | 1.0 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.1 | GO:0033092 | positive regulation of immature T cell proliferation in thymus(GO:0033092) |
| 0.0 | 0.3 | GO:0070072 | vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.0 | 0.2 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
| 0.0 | 0.1 | GO:1904245 | regulation of polynucleotide adenylyltransferase activity(GO:1904245) |
| 0.0 | 0.3 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.0 | 0.4 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 0.4 | GO:0048312 | intracellular distribution of mitochondria(GO:0048312) |
| 0.0 | 0.5 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.0 | 0.6 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.4 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 4.2 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.0 | 1.1 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 0.4 | GO:1900745 | positive regulation of p38MAPK cascade(GO:1900745) |
| 0.0 | 0.2 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.9 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 0.1 | GO:1905076 | interleukin-17 secretion(GO:0072615) regulation of interleukin-17 secretion(GO:1905076) positive regulation of T-helper 17 type immune response(GO:2000318) |
| 0.0 | 0.5 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.4 | GO:0051569 | regulation of histone H3-K4 methylation(GO:0051569) |
| 0.0 | 0.3 | GO:0000076 | DNA replication checkpoint(GO:0000076) |
| 0.0 | 1.0 | GO:0046579 | positive regulation of Ras protein signal transduction(GO:0046579) |
| 0.0 | 0.1 | GO:2000291 | regulation of myoblast proliferation(GO:2000291) |
| 0.0 | 0.4 | GO:0034629 | cellular protein complex localization(GO:0034629) |
| 0.0 | 1.0 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.0 | 0.3 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 0.0 | 0.1 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.0 | 0.2 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.1 | GO:1900194 | receptor guanylyl cyclase signaling pathway(GO:0007168) negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194) |
| 0.0 | 0.6 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.0 | 1.4 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.0 | 0.9 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 0.4 | GO:0032411 | positive regulation of transporter activity(GO:0032411) |
| 0.0 | 0.2 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 1.4 | GO:0007612 | learning(GO:0007612) |
| 0.0 | 1.5 | GO:0007411 | axon guidance(GO:0007411) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 8.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 1.3 | 5.4 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.5 | 2.9 | GO:0008091 | spectrin(GO:0008091) |
| 0.5 | 1.8 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.3 | 5.5 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.2 | 2.7 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.2 | 0.9 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.2 | 0.7 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.2 | 1.3 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.2 | 0.6 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.2 | 1.0 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 1.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 1.8 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 2.3 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 1.0 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 2.8 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 3.0 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.1 | 4.2 | GO:0030118 | clathrin coat(GO:0030118) |
| 0.1 | 0.9 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 0.3 | GO:0005940 | septin ring(GO:0005940) |
| 0.1 | 10.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.1 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.1 | 0.7 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.1 | 1.3 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 3.0 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.1 | 1.3 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.1 | 0.8 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 0.9 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 0.5 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.1 | 2.7 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 3.2 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 1.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 1.5 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 16.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 0.4 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 3.0 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.3 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.0 | 1.1 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.8 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.0 | 0.5 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.0 | 0.4 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.9 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.7 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.0 | 0.4 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 1.0 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.3 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 1.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 11.1 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 0.3 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.0 | 1.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.9 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.3 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.1 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.7 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 0.2 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.9 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 8.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.8 | 2.5 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.8 | 10.4 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.6 | 3.0 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 0.5 | 2.5 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.4 | 1.3 | GO:0015182 | L-asparagine transmembrane transporter activity(GO:0015182) |
| 0.4 | 2.8 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795) |
| 0.4 | 3.3 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.4 | 3.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.3 | 1.3 | GO:0034739 | histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903) |
| 0.3 | 1.3 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.3 | 0.9 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.3 | 0.9 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.3 | 0.5 | GO:0090554 | phosphatidylcholine-translocating ATPase activity(GO:0090554) |
| 0.3 | 1.8 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.2 | 0.7 | GO:0019002 | GMP binding(GO:0019002) |
| 0.2 | 1.7 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.2 | 2.9 | GO:0035014 | phosphatidylinositol 3-kinase regulator activity(GO:0035014) |
| 0.2 | 0.9 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.2 | 1.8 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.2 | 2.7 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
| 0.2 | 0.8 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.2 | 2.6 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.2 | 0.8 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.2 | 1.0 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.2 | 1.2 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.2 | 2.7 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.2 | 1.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 0.7 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.1 | 0.4 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.1 | 0.6 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 6.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 1.4 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
| 0.1 | 0.5 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.1 | 1.1 | GO:0005375 | copper ion transmembrane transporter activity(GO:0005375) |
| 0.1 | 1.7 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.1 | 0.2 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.1 | 0.4 | GO:0070051 | fibrinogen binding(GO:0070051) |
| 0.1 | 3.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 2.8 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 1.0 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 1.1 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 0.5 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 0.5 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 0.3 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 7.9 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 0.2 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.1 | 4.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.5 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.4 | GO:0005168 | neurotrophin TRKA receptor binding(GO:0005168) |
| 0.0 | 6.0 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.0 | 1.1 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 1.4 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 0.8 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 1.4 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 4.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 2.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 0.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.6 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.2 | GO:0042979 | ornithine decarboxylase regulator activity(GO:0042979) |
| 0.0 | 2.2 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 0.1 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.0 | 0.1 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.0 | 0.1 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.0 | 2.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.1 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.4 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 8.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.0 | 0.1 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.0 | 0.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 2.4 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.2 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
| 0.0 | 0.5 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.5 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 1.1 | GO:0016790 | thiolester hydrolase activity(GO:0016790) |
| 0.0 | 0.0 | GO:0001013 | RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164) |
| 0.0 | 1.2 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.0 | 1.3 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.4 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
| 0.0 | 0.4 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 8.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.4 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 1.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.4 | GO:0005272 | sodium channel activity(GO:0005272) |
| 0.0 | 0.8 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.3 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.6 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.4 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.2 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.0 | 0.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.3 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.7 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.2 | GO:0071949 | FAD binding(GO:0071949) |
| 0.0 | 0.9 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.1 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.5 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 1.8 | PID_NFKAPPAB_CANONICAL_PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 3.5 | PID_ERBB1_INTERNALIZATION_PATHWAY | Internalization of ErbB1 |
| 0.0 | 4.0 | WNT_SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 1.2 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.6 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.9 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.5 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.5 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.8 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.5 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 1.5 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.0 | 1.7 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.0 | 0.3 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 4.9 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.6 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.6 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.9 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.9 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.4 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.9 | PID_P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.0 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.2 | 2.8 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.2 | 4.0 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 3.9 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.2 | 1.8 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 0.3 | REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR | Genes involved in Downstream signaling of activated FGFR |
| 0.1 | 5.3 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 4.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 3.6 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.1 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.9 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 2.5 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 3.1 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 1.5 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 1.2 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 1.0 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 0.4 | REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 0.9 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 0.7 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 0.5 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 1.1 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.6 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.4 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.6 | REACTOME_P38MAPK_EVENTS | Genes involved in p38MAPK events |
| 0.0 | 1.2 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.6 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.3 | REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | Genes involved in Prolonged ERK activation events |
| 0.0 | 0.5 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.2 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.6 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.6 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.4 | REACTOME_RECYCLING_PATHWAY_OF_L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 0.5 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.2 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.2 | REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK | Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK |
| 0.0 | 0.3 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.4 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.2 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
