Motif ID: Zbtb14

Z-value: 2.128


Transcription factors associated with Zbtb14:

Gene SymbolEntrez IDGene Name
Zbtb14 ENSMUSG00000049672.8 Zbtb14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb14mm10_v2_chr17_+_69383768_693838400.484.4e-02Click!


Activity profile for motif Zbtb14.

activity profile for motif Zbtb14


Sorted Z-values histogram for motif Zbtb14

Sorted Z-values for motif Zbtb14



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_63212514 7.423 ENSMUST00000032738.5
 Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
chr11_-_7213897 6.452 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr10_+_13966268 6.034 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr11_+_104231573 5.986 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_-_6065737 5.918 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_+_104231515 5.652 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_-_6065538 5.463 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr11_+_104231465 5.429 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr15_+_83779975 5.363 ENSMUST00000163723.1
 Mpped1
metallophosphoesterase domain containing 1
chr11_+_104231390 5.029 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr7_-_27396542 4.898 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr10_+_58813359 4.747 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr15_+_83779999 4.710 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr2_-_104410334 4.565 ENSMUST00000089726.3
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr12_-_100725028 4.394 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr14_-_102982630 4.312 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr1_-_160792908 4.283 ENSMUST00000028049.7
 Rabgap1l
RAB GTPase activating protein 1-like
chr4_+_42917234 4.182 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr11_+_7063423 4.169 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr4_+_48045144 3.975 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 378 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 22.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
3.8 11.4 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
1.8 10.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 9.5 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
2.5 7.4 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.4 6.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.0 6.1 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.5 6.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 5.8 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)
1.4 5.4 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.2 5.0 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 4.6 GO:0008210 estrogen metabolic process(GO:0008210)
1.5 4.4 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.7 4.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.4 4.3 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 4.3 GO:0015914 phospholipid transport(GO:0015914)
1.4 4.2 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.2 4.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
1.3 4.0 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
1.3 3.9 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 22.1 GO:0045298 tubulin complex(GO:0045298)
0.2 13.3 GO:0031594 neuromuscular junction(GO:0031594)
0.1 12.2 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 10.0 GO:0051233 spindle midzone(GO:0051233)
0.1 8.4 GO:0070382 exocytic vesicle(GO:0070382)
1.3 7.9 GO:0008091 spectrin(GO:0008091)
0.7 7.4 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 7.1 GO:0000139 Golgi membrane(GO:0000139)
0.3 7.0 GO:0033268 node of Ranvier(GO:0033268)
0.4 6.8 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
1.6 6.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.5 6.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 5.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 4.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.7 4.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 4.3 GO:0044295 axonal growth cone(GO:0044295)
0.1 4.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 4.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 4.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.8 3.9 GO:1990761 growth cone lamellipodium(GO:1990761)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 22.1 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 13.8 GO:0005096 GTPase activator activity(GO:0005096)
0.5 12.3 GO:0043274 phospholipase binding(GO:0043274)
0.5 10.9 GO:0030506 ankyrin binding(GO:0030506)
0.7 7.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
1.3 6.5 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.6 6.4 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 6.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 6.2 GO:0005158 insulin receptor binding(GO:0005158)
1.1 5.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.3 5.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.9 5.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.2 5.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 5.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.6 5.0 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.3 4.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 4.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.5 4.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 4.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.2 4.0 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 22.1 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.5 11.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.6 10.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 10.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.8 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 6.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 6.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 5.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.3 PID_IGF1_PATHWAY IGF1 pathway
0.1 3.2 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 3.2 PID_INSULIN_PATHWAY Insulin Pathway
0.0 3.0 PID_P73PATHWAY p73 transcription factor network
0.1 2.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 1.9 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 1.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 1.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 23.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 14.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.6 12.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.3 10.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.8 7.4 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.2 7.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 6.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 6.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 5.1 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 4.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 4.1 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 3.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 3.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.5 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 3.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 3.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.2 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 3.1 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 2.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 2.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling