Motif ID: Rfx3_Rfx1_Rfx4

Z-value: 1.982

Transcription factors associated with Rfx3_Rfx1_Rfx4:

Gene SymbolEntrez IDGene Name
Rfx1 ENSMUSG00000031706.6 Rfx1
Rfx3 ENSMUSG00000040929.10 Rfx3
Rfx4 ENSMUSG00000020037.9 Rfx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx4mm10_v2_chr10_+_84756055_84756084-0.762.3e-04Click!
Rfx3mm10_v2_chr19_-_28011138_28011181-0.282.6e-01Click!
Rfx1mm10_v2_chr8_+_84066824_84066882-0.204.3e-01Click!


Activity profile for motif Rfx3_Rfx1_Rfx4.

activity profile for motif Rfx3_Rfx1_Rfx4


Sorted Z-values histogram for motif Rfx3_Rfx1_Rfx4

Sorted Z-values for motif Rfx3_Rfx1_Rfx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7919816 6.156 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr15_+_98167806 3.400 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr4_-_119415494 3.297 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30
chr7_-_140082246 2.826 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr7_-_140082489 2.647 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr1_-_60043087 2.598 ENSMUST00000027172.6
 Ica1l
islet cell autoantigen 1-like
chr7_-_4546567 2.510 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr10_-_81472859 2.443 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr12_+_29528382 2.368 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr17_+_34629533 2.278 ENSMUST00000015620.6
 Prrt1
proline-rich transmembrane protein 1
chr9_+_59589288 2.242 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr11_+_70029742 2.165 ENSMUST00000132597.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr10_+_106470281 2.088 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr7_-_31051431 1.996 ENSMUST00000073892.4
 Fxyd7
FXYD domain-containing ion transport regulator 7
chr19_-_46327121 1.972 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr17_+_46254017 1.894 ENSMUST00000095262.4
 Lrrc73
leucine rich repeat containing 73
chr16_-_16829276 1.885 ENSMUST00000023468.5
 Spag6
sperm associated antigen 6
chr11_-_61453992 1.842 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
 Rnf112


ring finger protein 112


chr12_-_84148449 1.738 ENSMUST00000061425.2
 Pnma1
paraneoplastic antigen MA1
chr10_-_13868779 1.733 ENSMUST00000105534.3
 Aig1
androgen-induced 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 6.2 GO:0016486 peptide hormone processing(GO:0016486)
0.2 5.9 GO:0071625 vocalization behavior(GO:0071625)
0.2 5.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 4.3 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.2 3.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.5 3.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.4 2.6 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 2.4 GO:0048665 neuron fate specification(GO:0048665)
0.5 2.1 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.2 2.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 2.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.4 2.0 GO:0021508 floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505)
0.1 2.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.0 GO:0060074 synapse maturation(GO:0060074)
0.4 1.8 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.2 1.8 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 1.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.8 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.4 1.7 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.5 GO:0005802 trans-Golgi network(GO:0005802)
0.1 6.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
1.3 5.2 GO:1990769 proximal neuron projection(GO:1990769)
0.1 3.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 3.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 2.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 2.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 2.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.0 GO:0043679 axon terminus(GO:0043679)
0.0 2.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.8 GO:0016235 aggresome(GO:0016235)
0.2 1.7 GO:0005915 zonula adherens(GO:0005915)
0.0 1.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.6 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.0 1.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.4 GO:0097542 ciliary tip(GO:0097542)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 118 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.9 GO:0008017 microtubule binding(GO:0008017)
0.1 6.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 6.1 GO:0003779 actin binding(GO:0003779)
0.7 5.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 5.4 GO:0016247 channel regulator activity(GO:0016247)
0.8 3.2 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 2.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 2.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.8 2.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.3 2.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 2.4 GO:0050897 cobalt ion binding(GO:0050897)
0.2 2.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 2.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.0 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 1.9 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.8 GO:0032183 SUMO binding(GO:0032183)
0.0 1.8 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 1.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.5 1.6 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 1.5 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 2.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.6 PID_P73PATHWAY p73 transcription factor network
0.0 1.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.1 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 0.4 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.4 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 0.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.3 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 4.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 4.0 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 3.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.4 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.1 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 1.0 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 0.9 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 0.9 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.9 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.8 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.8 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.1 0.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac