Motif ID: Smarcc1_Fosl1

Z-value: 0.757

Transcription factors associated with Smarcc1_Fosl1:

Gene SymbolEntrez IDGene Name
Fosl1 ENSMUSG00000024912.5 Fosl1
Smarcc1 ENSMUSG00000032481.10 Smarcc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl1mm10_v2_chr19_+_5447692_54477110.798.7e-05Click!
Smarcc1mm10_v2_chr9_+_110132015_1101321020.223.8e-01Click!


Activity profile for motif Smarcc1_Fosl1.

activity profile for motif Smarcc1_Fosl1


Sorted Z-values histogram for motif Smarcc1_Fosl1

Sorted Z-values for motif Smarcc1_Fosl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smarcc1_Fosl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 1.708 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr5_+_117841839 1.508 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr9_-_20728219 1.356 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr4_+_42091207 1.331 ENSMUST00000178882.1
 Gm3893
predicted gene 3893
chr19_-_59076069 1.288 ENSMUST00000047511.7
ENSMUST00000163821.1
 4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr15_-_66812593 1.268 ENSMUST00000100572.3
 Sla
src-like adaptor
chr9_+_32224457 1.220 ENSMUST00000183121.1
 Arhgap32
Rho GTPase activating protein 32
chr2_+_156475803 1.188 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr6_+_135362931 1.181 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr1_+_58210397 1.149 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr2_-_45110241 1.137 ENSMUST00000177302.1
 Zeb2
zinc finger E-box binding homeobox 2
chr2_+_156475844 1.126 ENSMUST00000103135.1
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr13_-_54611332 1.071 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr11_+_3330781 1.052 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr13_-_54611274 0.985 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr3_+_101377074 0.963 ENSMUST00000043983.5
 Igsf3
immunoglobulin superfamily, member 3
chr1_-_134235420 0.956 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr13_+_119623819 0.953 ENSMUST00000099241.2
 Ccl28
chemokine (C-C motif) ligand 28
chr10_+_86779000 0.925 ENSMUST00000099396.2
 Nt5dc3
5'-nucleotidase domain containing 3
chr15_-_33687840 0.912 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 361 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.0 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 2.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 1.9 GO:0006906 vesicle fusion(GO:0006906)
0.0 1.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.6 1.7 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
0.3 1.6 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.3 1.6 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 1.4 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.4 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 1.4 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.1 1.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 1.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.2 GO:0030641 regulation of cellular pH(GO:0030641)
0.4 1.1 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 1.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 1.1 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.2 1.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 1.1 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.1 GO:0015807 L-amino acid transport(GO:0015807)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 3.2 GO:0060076 excitatory synapse(GO:0060076)
0.0 2.4 GO:0055037 recycling endosome(GO:0055037)
0.2 2.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 2.2 GO:0042734 presynaptic membrane(GO:0042734)
0.3 2.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 2.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.2 1.1 GO:0005638 lamin filament(GO:0005638)
0.1 1.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.0 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.9 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.8 GO:0008017 microtubule binding(GO:0008017)
0.1 2.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 2.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.9 GO:0005516 calmodulin binding(GO:0005516)
0.1 1.8 GO:0051787 misfolded protein binding(GO:0051787)
0.0 1.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 1.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.5 1.4 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.4 1.2 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 1.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.2 GO:0030674 protein binding, bridging(GO:0030674)
0.3 1.1 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 1.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 1.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 1.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.0 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.9 PID_ARF6_PATHWAY Arf6 signaling events
0.1 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.8 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.6 PID_PI3KCI_PATHWAY Class I PI3K signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.0 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.7 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 1.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.1 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.0 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 1.0 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.0 REACTOME_SOS_MEDIATED_SIGNALLING Genes involved in SOS-mediated signalling
0.0 1.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 0.9 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.9 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport