Motif ID: Hmx3

Z-value: 0.241


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.204.2e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_53707532 0.736 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr3_-_154328634 0.374 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chrX_-_60893430 0.305 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr5_-_87482258 0.300 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr2_-_72986716 0.270 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr17_-_35697971 0.237 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr10_-_80421847 0.224 ENSMUST00000156244.1
 Tcf3
transcription factor 3
chr4_-_129261394 0.208 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr12_-_83921809 0.195 ENSMUST00000135962.1
ENSMUST00000155112.1
ENSMUST00000136848.1
ENSMUST00000126943.1
 Numb



numb gene homolog (Drosophila)



chr1_-_158814469 0.189 ENSMUST00000161589.2
 Pappa2
pappalysin 2
chrM_+_9452 0.188 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr2_+_3114220 0.168 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr4_+_154960915 0.163 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr1_+_110099295 0.154 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr1_-_78968079 0.149 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr3_-_86548268 0.135 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr1_-_175979114 0.117 ENSMUST00000104983.1
 B020018G12Rik
RIKEN cDNA B020018G12 gene
chr5_+_121777929 0.115 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr1_-_190170671 0.114 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr13_+_23746734 0.113 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr15_-_13173607 0.112 ENSMUST00000036439.4
 Cdh6
cadherin 6
chr9_+_21955747 0.111 ENSMUST00000053583.5
 Swsap1
SWIM type zinc finger 7 associated protein 1
chr12_-_83921899 0.094 ENSMUST00000117217.1
 Numb
numb gene homolog (Drosophila)
chr8_-_23237623 0.094 ENSMUST00000033950.5
 Gins4
GINS complex subunit 4 (Sld5 homolog)
chr3_+_96629919 0.086 ENSMUST00000048915.6
 Rbm8a
RNA binding motif protein 8a
chrM_+_3906 0.083 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr3_-_142169311 0.081 ENSMUST00000106230.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr5_+_15516489 0.081 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr15_+_9436028 0.073 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr4_-_62470868 0.067 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr12_-_108179210 0.065 ENSMUST00000125916.2
ENSMUST00000109879.1
 Setd3

SET domain containing 3

chr2_-_84715160 0.061 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr10_+_115569986 0.061 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene
chr12_+_108179738 0.060 ENSMUST00000101055.4
 Ccnk
cyclin K
chr4_-_45532470 0.050 ENSMUST00000147448.1
 Shb
src homology 2 domain-containing transforming protein B
chr4_+_134397380 0.048 ENSMUST00000105870.1
 Pafah2
platelet-activating factor acetylhydrolase 2
chr7_-_127208423 0.046 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chrX_+_150594420 0.042 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr9_-_123678873 0.038 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr6_+_86371489 0.036 ENSMUST00000089558.5
 Snrpg
small nuclear ribonucleoprotein polypeptide G
chr7_-_30559828 0.033 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chr9_-_123678782 0.032 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr14_+_73552665 0.030 ENSMUST00000160507.1
ENSMUST00000022706.6
 Sucla2

succinate-Coenzyme A ligase, ADP-forming, beta subunit

chr18_+_61639542 0.025 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr7_-_45510400 0.017 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr9_+_52047150 0.016 ENSMUST00000163153.1
 Rdx
radixin
chr7_+_3645267 0.014 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr7_-_121035096 0.014 ENSMUST00000065740.2
 Gm9905
predicted gene 9905
chr4_+_65604984 0.005 ENSMUST00000050850.7
ENSMUST00000107366.1
 Trim32

tripartite motif-containing 32

chr17_-_57247632 0.002 ENSMUST00000005975.6
 Gpr108
G protein-coupled receptor 108
chr19_+_8802486 0.000 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.1 0.3 GO:0030862 neuroblast division in subventricular zone(GO:0021849) positive regulation of polarized epithelial cell differentiation(GO:0030862)
0.1 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.3 GO:2000977 regulation of forebrain neuron differentiation(GO:2000977)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.3 GO:0007530 sex determination(GO:0007530)
0.0 0.1 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 0.0 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)