Motif ID: Nfe2l2

Z-value: 0.718


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_757046410.233.7e-01Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_126799163 2.423 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126799134 2.350 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chr5_-_53707532 2.281 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr3_+_131110350 2.077 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr5_+_128601106 2.045 ENSMUST00000117102.2
 Fzd10
frizzled homolog 10 (Drosophila)
chr4_+_116685859 1.723 ENSMUST00000129315.1
ENSMUST00000106470.1
 Prdx1

peroxiredoxin 1

chr4_+_116685544 1.650 ENSMUST00000135573.1
ENSMUST00000151129.1
 Prdx1

peroxiredoxin 1

chrX_-_52613913 1.646 ENSMUST00000069360.7
 Gpc3
glypican 3
chr7_-_44997535 1.398 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr10_+_17796256 1.397 ENSMUST00000037964.6
 Txlnb
taxilin beta
chr2_+_180171485 1.290 ENSMUST00000061437.4
 Adrm1
adhesion regulating molecule 1
chrX_-_52613936 1.271 ENSMUST00000114857.1
 Gpc3
glypican 3
chr3_+_28805436 1.240 ENSMUST00000043867.5
 Rpl22l1
ribosomal protein L22 like 1
chr18_-_53418004 1.107 ENSMUST00000025419.7
 Ppic
peptidylprolyl isomerase C
chr7_-_44997221 1.085 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr7_-_17056669 1.015 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr17_+_86963279 1.003 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr4_-_57956283 0.981 ENSMUST00000030051.5
 Txn1
thioredoxin 1
chrX_-_38252398 0.980 ENSMUST00000089056.3
ENSMUST00000089054.4
ENSMUST00000066498.7
 Tmem255a


transmembrane protein 255A


chr14_+_62292475 0.979 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.5 4.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.0 2.9 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.2 2.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.8 2.3 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.7 2.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.3 2.0 GO:0038031 non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0 1.4 GO:0032543 mitochondrial translation(GO:0032543)
0.2 1.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 1.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 1.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.1 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 1.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 1.0 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 1.0 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 1.0 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.2 0.9 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.2 0.9 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.2 0.9 GO:0002934 desmosome organization(GO:0002934)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 3.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 3.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 3.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 2.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.3 GO:0043195 terminal bouton(GO:0043195)
0.1 2.2 GO:0005838 proteasome regulatory particle(GO:0005838)
0.2 2.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.4 GO:0044306 neuron projection terminus(GO:0044306)
0.0 1.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.2 1.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 0.9 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.2 0.9 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.8 GO:0016460 myosin II complex(GO:0016460)
0.2 0.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 0.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.6 GO:0000235 astral microtubule(GO:0000235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 3.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 3.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 3.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.5 GO:0002039 p53 binding(GO:0002039)
0.0 2.3 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.3 2.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 2.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 1.6 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.1 1.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 1.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 1.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 1.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.2 1.0 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 1.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.0 GO:0005522 profilin binding(GO:0005522)
0.2 0.9 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.2 0.9 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.4 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 2.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.2 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.0 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.0 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.3 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 4.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 2.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.5 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.0 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.6 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 0.5 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 0.5 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.4 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.4 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle