Motif ID: Runx1

Z-value: 1.100


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 9.814 ENSMUST00000168589.1
 Sla
src-like adaptor
chr17_+_3397189 4.604 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr16_+_42907563 4.530 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr8_-_11008458 3.610 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr2_+_37516618 3.354 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr2_-_52558539 2.856 ENSMUST00000102760.3
ENSMUST00000102761.2
 Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr4_+_102760294 2.627 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
 Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr15_-_76090013 2.589 ENSMUST00000019516.4
 Nrbp2
nuclear receptor binding protein 2
chrX_+_159697308 2.486 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr13_+_76579670 2.476 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chrX_+_151344171 2.407 ENSMUST00000073364.5
 Fam120c
family with sequence similarity 120, member C
chr10_+_69925954 2.284 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr2_-_52335134 2.219 ENSMUST00000075301.3
 Neb
nebulin
chr9_+_113812547 2.181 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr17_-_90455872 2.180 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr14_-_124677089 2.168 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14
chr12_-_25096080 2.147 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr13_+_49608030 2.145 ENSMUST00000021822.5
 Ogn
osteoglycin
chr8_+_76902277 2.114 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr1_-_169747634 2.107 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 6.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 4.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 4.1 GO:0015807 L-amino acid transport(GO:0015807)
0.4 3.6 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 3.4 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.3 2.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.4 2.7 GO:0019532 oxalate transport(GO:0019532)
0.0 2.7 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.3 2.6 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 2.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.5 2.2 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.4 2.2 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.3 2.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.4 2.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 2.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 2.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 2.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.7 2.0 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 1.9 GO:0048305 immunoglobulin secretion(GO:0048305)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 2.6 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 2.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 2.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.3 GO:0030139 endocytic vesicle(GO:0030139)
0.5 2.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.2 2.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.2 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 2.2 GO:0005865 striated muscle thin filament(GO:0005865)
0.7 2.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.1 GO:0001520 outer dense fiber(GO:0001520)
0.3 1.0 GO:0031673 H zone(GO:0031673)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 0.7 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.6 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 5.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 4.2 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 4.1 GO:0008083 growth factor activity(GO:0008083)
0.0 3.7 GO:0017124 SH3 domain binding(GO:0017124)
0.8 3.4 GO:0004952 dopamine neurotransmitter receptor activity(GO:0004952)
0.1 3.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 2.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 2.7 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 2.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 2.3 GO:0030507 spectrin binding(GO:0030507)
0.2 2.2 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 2.2 GO:0002162 dystroglycan binding(GO:0002162)
0.0 2.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 2.1 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.2 1.5 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.3 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 5.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 3.6 PID_EPO_PATHWAY EPO signaling pathway
0.0 2.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 2.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 2.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.5 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.0 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID_TCR_PATHWAY TCR signaling in naïve CD4+ T cells
0.1 0.8 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.7 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.7 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 3.6 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 2.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 2.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.1 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 1.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.2 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.1 1.1 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.1 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.6 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism