Motif ID: Tgif2_Tgif2lx1_Tgif2lx2

Z-value: 0.745

Transcription factors associated with Tgif2_Tgif2lx1_Tgif2lx2:

Gene SymbolEntrez IDGene Name
Tgif2 ENSMUSG00000062175.7 Tgif2
Tgif2lx1 ENSMUSG00000061283.4 Tgif2lx1
Tgif2lx2 ENSMUSG00000063242.6 Tgif2lx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tgif2mm10_v2_chr2_+_156840966_156841017-0.204.3e-01Click!


Activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2.

activity profile for motif Tgif2_Tgif2lx1_Tgif2lx2


Sorted Z-values histogram for motif Tgif2_Tgif2lx1_Tgif2lx2

Sorted Z-values for motif Tgif2_Tgif2lx1_Tgif2lx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tgif2_Tgif2lx1_Tgif2lx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 173 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_19103022 2.109 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr11_+_98348404 1.607 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr13_-_76385028 1.513 ENSMUST00000099365.1
 Gm10760
predicted gene 10760
chr5_-_45857473 1.490 ENSMUST00000016026.7
ENSMUST00000067997.6
ENSMUST00000045586.6
 Lcorl


ligand dependent nuclear receptor corepressor-like


chr2_+_82053222 1.137 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr17_+_86753900 1.123 ENSMUST00000024954.9
 Epas1
endothelial PAS domain protein 1
chr13_+_54949388 0.814 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr6_-_88875035 0.694 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr9_+_78175898 0.655 ENSMUST00000180974.1
 C920006O11Rik
RIKEN cDNA C920006O11 gene
chr6_-_88874597 0.640 ENSMUST00000061262.4
ENSMUST00000140455.1
ENSMUST00000145780.1
 Podxl2


podocalyxin-like 2


chr15_+_85510812 0.574 ENSMUST00000079690.2
 Gm4825
predicted pseudogene 4825
chr11_-_20741447 0.554 ENSMUST00000177543.1
 Aftph
aftiphilin
chr1_+_36307745 0.503 ENSMUST00000142319.1
ENSMUST00000097778.2
ENSMUST00000115031.1
ENSMUST00000115032.1
ENSMUST00000137906.1
ENSMUST00000115029.1
 Arid5a





AT rich interactive domain 5A (MRF1-like)





chr5_-_100159261 0.497 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr17_+_87025550 0.484 ENSMUST00000024959.3
ENSMUST00000160269.1
 Cript

cysteine-rich PDZ-binding protein

chr7_-_61982290 0.475 ENSMUST00000180481.1
 A330076H08Rik
RIKEN cDNA A330076H08 gene
chr8_+_122611618 0.474 ENSMUST00000015157.8
 Trappc2l
trafficking protein particle complex 2-like
chr6_-_106800051 0.452 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
 Crbn


cereblon


chr2_-_25461094 0.433 ENSMUST00000114261.2
 BC029214
cDNA sequence BC029214
chr7_-_61982348 0.421 ENSMUST00000181804.1
ENSMUST00000181187.1
 A330076H08Rik

RIKEN cDNA A330076H08 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0030901 midbrain development(GO:0030901)
0.5 1.6 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 1.3 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.2 1.1 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.1 0.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.6 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 0.5 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.1 0.5 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1 0.5 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.5 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.1 0.3 GO:0071873 response to norepinephrine(GO:0071873)
0.0 0.3 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.2 GO:0003195 tricuspid valve formation(GO:0003195) right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.2 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.2 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0 0.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.7 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.5 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.3 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0097513 myosin II filament(GO:0097513)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.0 GO:0030905 retromer, tubulation complex(GO:0030905)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1 1.1 GO:0050897 cobalt ion binding(GO:0050897)
0.1 0.8 GO:0005042 netrin receptor activity(GO:0005042)
0.1 0.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.4 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.1 0.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.2 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.1 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0070330 aromatase activity(GO:0070330)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.1 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 0.8 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol