Motif ID: Gli1

Z-value: 0.534


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.292.5e-01Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 176 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_25607797 1.173 ENSMUST00000160229.1
 Zmiz1
zinc finger, MIZ-type containing 1
chr9_+_50752758 0.954 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr7_-_118443549 0.787 ENSMUST00000081574.4
 Syt17
synaptotagmin XVII
chr15_-_78544345 0.715 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr11_+_80300866 0.661 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr18_-_43373248 0.641 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3
chr11_-_119547744 0.618 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr1_-_133801031 0.615 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr2_-_54085542 0.612 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_-_59948155 0.554 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr2_+_118111876 0.550 ENSMUST00000039559.8
 Thbs1
thrombospondin 1
chr9_+_45954101 0.525 ENSMUST00000181487.1
 A830035O19Rik
RIKEN cDNA A830035O19 gene
chr13_+_44729535 0.493 ENSMUST00000174068.1
 Jarid2
jumonji, AT rich interactive domain 2
chr1_+_129273344 0.490 ENSMUST00000073527.6
ENSMUST00000040311.7
 Thsd7b

thrombospondin, type I, domain containing 7B

chr2_-_36104060 0.488 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chrX_+_159303266 0.479 ENSMUST00000112491.1
 Rps6ka3
ribosomal protein S6 kinase polypeptide 3
chr7_+_73391160 0.474 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr8_+_45658273 0.452 ENSMUST00000153798.1
 Sorbs2
sorbin and SH3 domain containing 2
chr12_-_81333129 0.444 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr2_+_20737306 0.432 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.2 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.2 1.2 GO:0007296 vitellogenesis(GO:0007296)
0.0 1.1 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 1.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 0.7 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.7 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.6 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1 0.6 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 0.6 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.6 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 0.5 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.0 0.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.5 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.1 0.4 GO:2000331 regulation of terminal button organization(GO:2000331)
0.1 0.4 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 0.4 GO:0021993 initiation of neural tube closure(GO:0021993)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.0 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.2 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.2 0.7 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 0.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.6 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 0.5 GO:0070052 collagen V binding(GO:0070052)
0.0 0.5 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.5 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.3 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.3 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.1 0.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.4 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis