Motif ID: Lhx3

Z-value: 0.497


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 1.113 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr18_+_57468478 0.957 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr14_+_80000292 0.865 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_+_96115249 0.834 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr13_+_49608030 0.743 ENSMUST00000021822.5
 Ogn
osteoglycin
chr4_+_102589687 0.716 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr13_-_101692624 0.702 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_+_82053222 0.634 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr1_+_177444653 0.615 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr10_-_64090265 0.610 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chrX_-_143933204 0.606 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr1_-_158356258 0.552 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_-_53647080 0.517 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr7_-_45103747 0.504 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr10_+_36506814 0.501 ENSMUST00000167191.1
ENSMUST00000058738.4
 Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr3_+_151437887 0.497 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr3_+_136670076 0.491 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr4_+_145585166 0.475 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr1_-_38821215 0.464 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr4_-_14621805 0.461 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.2 0.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.5 GO:0019532 oxalate transport(GO:0019532)
0.1 0.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.3 GO:0030903 notochord development(GO:0030903)
0.1 0.2 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0 0.2 GO:0060746 parental behavior(GO:0060746)
0.0 0.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.9 GO:0042581 specific granule(GO:0042581)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 0.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors