Motif ID: Lhx3

Z-value: 0.497


Transcription factors associated with Lhx3:

Gene SymbolEntrez IDGene Name
Lhx3 ENSMUSG00000026934.9 Lhx3



Activity profile for motif Lhx3.

activity profile for motif Lhx3


Sorted Z-values histogram for motif Lhx3

Sorted Z-values for motif Lhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Lhx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103827922 1.113 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr18_+_57468478 0.957 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr14_+_80000292 0.865 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr6_+_96115249 0.834 ENSMUST00000075080.5
 Fam19a1
family with sequence similarity 19, member A1
chr13_+_49608030 0.743 ENSMUST00000021822.5
 Ogn
osteoglycin
chr4_+_102589687 0.716 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr13_-_101692624 0.702 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr2_+_82053222 0.634 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr1_+_177444653 0.615 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr10_-_64090265 0.610 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chrX_-_143933204 0.606 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr1_-_158356258 0.552 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_-_53647080 0.517 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr7_-_45103747 0.504 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr10_+_36506814 0.501 ENSMUST00000167191.1
ENSMUST00000058738.4
 Hs3st5

heparan sulfate (glucosamine) 3-O-sulfotransferase 5

chr3_+_151437887 0.497 ENSMUST00000046977.7
 Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr3_+_136670076 0.491 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr4_+_145585166 0.475 ENSMUST00000105739.1
ENSMUST00000119718.1
 Gm13212

predicted gene 13212

chr1_-_38821215 0.464 ENSMUST00000039612.4
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr4_-_14621805 0.461 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr10_-_33624587 0.443 ENSMUST00000160299.1
ENSMUST00000019920.6
 Clvs2

clavesin 2

chr19_+_26623419 0.436 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_23069210 0.408 ENSMUST00000155602.1
 Acbd5
acyl-Coenzyme A binding domain containing 5
chr17_-_67950908 0.383 ENSMUST00000164647.1
 Arhgap28
Rho GTPase activating protein 28
chr8_-_109251698 0.382 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr5_-_118244861 0.372 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr3_-_41742471 0.356 ENSMUST00000026866.8
 Sclt1
sodium channel and clathrin linker 1
chr14_-_108914237 0.353 ENSMUST00000100322.2
 Slitrk1
SLIT and NTRK-like family, member 1
chr8_-_21906412 0.351 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr4_+_136143497 0.339 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr5_+_66968961 0.332 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr2_-_33087169 0.318 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr4_-_147809788 0.318 ENSMUST00000105734.3
ENSMUST00000176201.1
 Gm13157
Gm20707
predicted gene 13157
predicted gene 20707
chr4_+_147132038 0.316 ENSMUST00000084149.3
 Gm13139
predicted gene 13139
chrX_-_143933089 0.307 ENSMUST00000087313.3
 Dcx
doublecortin
chr13_+_93304066 0.305 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr2_-_33086366 0.301 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_125136692 0.294 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr9_+_113812547 0.290 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr13_+_93304799 0.281 ENSMUST00000080127.5
 Homer1
homer homolog 1 (Drosophila)
chr3_+_53845086 0.277 ENSMUST00000108014.1
 Gm10985
predicted gene 10985
chr10_-_64090241 0.270 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr18_+_37477768 0.243 ENSMUST00000051442.5
 Pcdhb16
protocadherin beta 16
chrX_-_94123087 0.236 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr5_-_70842617 0.233 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr2_-_164171113 0.233 ENSMUST00000045196.3
 Kcns1
K+ voltage-gated channel, subfamily S, 1
chr5_-_62766153 0.223 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_60774510 0.217 ENSMUST00000025511.3
 Rps14
ribosomal protein S14
chr3_-_57294880 0.212 ENSMUST00000171384.1
 Tm4sf1
transmembrane 4 superfamily member 1
chr18_+_60774675 0.205 ENSMUST00000118551.1
 Rps14
ribosomal protein S14
chr2_-_72986716 0.190 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr17_-_36032682 0.181 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr4_+_118961578 0.177 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr2_+_110597298 0.152 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr10_+_102158858 0.132 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr4_+_147492417 0.129 ENSMUST00000105721.2
 Gm13152
predicted gene 13152
chrX_+_166344692 0.125 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
 Gpm6b





glycoprotein m6b





chr13_-_74482943 0.124 ENSMUST00000074369.6
 Zfp825
zinc finger protein 825
chr3_+_41742615 0.113 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr3_+_142620596 0.106 ENSMUST00000165774.1
 Gbp2
guanylate binding protein 2
chr2_-_73580288 0.104 ENSMUST00000028515.3
 Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
chr10_+_116143881 0.100 ENSMUST00000105271.2
 Ptprr
protein tyrosine phosphatase, receptor type, R
chr10_-_62507737 0.100 ENSMUST00000020271.6
 Srgn
serglycin
chr5_-_62765618 0.097 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_+_37870786 0.095 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24

chr1_-_36273425 0.086 ENSMUST00000056946.6
 Neurl3
neuralized homolog 3 homolog (Drosophila)
chr4_-_14621669 0.063 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr2_+_36230426 0.045 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr12_+_71170589 0.041 ENSMUST00000129376.1
 2700049A03Rik
RIKEN cDNA 2700049A03 gene
chr16_+_11406618 0.037 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr8_-_106573461 0.032 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr3_-_116712644 0.028 ENSMUST00000029569.2
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr15_+_16778101 0.025 ENSMUST00000026432.6
 Cdh9
cadherin 9
chr14_+_58893465 0.019 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr11_+_6560183 0.016 ENSMUST00000109722.2
 Ccm2
cerebral cavernous malformation 2
chr4_+_146610961 0.016 ENSMUST00000130825.1
 Gm13248
predicted gene 13248
chr7_-_30534180 0.013 ENSMUST00000044338.4
 Arhgap33
Rho GTPase activating protein 33
chr6_+_124304646 0.012 ENSMUST00000112541.2
ENSMUST00000032234.2
 Cd163

CD163 antigen

chr19_+_3768112 0.011 ENSMUST00000005518.9
ENSMUST00000113967.1
ENSMUST00000152935.1
ENSMUST00000176262.1
ENSMUST00000176407.1
ENSMUST00000176926.1
ENSMUST00000176512.1
 Suv420h1






suppressor of variegation 4-20 homolog 1 (Drosophila)






chr4_+_145510759 0.009 ENSMUST00000105742.1
ENSMUST00000136309.1
 Gm13225

predicted gene 13225

chr17_-_56036546 0.008 ENSMUST00000003268.9
 Sh3gl1
SH3-domain GRB2-like 1
chr11_+_109543694 0.008 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chrM_+_14138 0.002 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.1 0.4 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.4 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.7 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 0.5 GO:0019532 oxalate transport(GO:0019532)
0.1 0.9 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.2 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.9 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 0.4 GO:0030242 pexophagy(GO:0030242)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.3 GO:0030903 notochord development(GO:0030903)
0.0 0.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.2 GO:0060746 parental behavior(GO:0060746)
0.0 0.0 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.9 GO:0042581 specific granule(GO:0042581)
0.0 0.4 GO:0071439 clathrin complex(GO:0071439)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0042629 mast cell granule(GO:0042629)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.2 0.7 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.5 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.2 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.1 0.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.2 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0050811 GABA-A receptor activity(GO:0004890) GABA receptor binding(GO:0050811)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.7 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis