Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.640

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx1mm10_v2_chr5_+_147188678_147188696-0.503.6e-02Click!
Alx1mm10_v2_chr10_-_103028771_1030287820.145.7e-01Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 3.462 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_+_103550368 3.404 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr5_+_139543889 3.251 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr13_+_44121167 1.899 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr1_+_137928100 1.799 ENSMUST00000054333.2
 A130050O07Rik
RIKEN cDNA A130050O07 gene
chrX_+_56454871 1.625 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chrM_+_7005 1.623 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr17_+_45734506 1.423 ENSMUST00000180558.1
 F630040K05Rik
RIKEN cDNA F630040K05 gene
chr2_-_116067391 1.379 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr3_-_110143937 1.376 ENSMUST00000051253.3
 Ntng1
netrin G1
chr2_+_116067213 1.326 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr5_-_62765618 1.313 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_152754156 1.224 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr8_-_84662841 1.117 ENSMUST00000060427.4
 Ier2
immediate early response 2
chrX_-_157415286 1.115 ENSMUST00000079945.4
ENSMUST00000138396.1
 Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr7_+_29071597 0.995 ENSMUST00000180926.1
 Gm26604
predicted gene, 26604
chr16_-_26989974 0.884 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr1_-_163725123 0.862 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr11_+_29373618 0.857 ENSMUST00000040182.6
ENSMUST00000109477.1
 Ccdc88a

coiled coil domain containing 88A

chr5_-_84417359 0.785 ENSMUST00000113401.1
 Epha5
Eph receptor A5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 2.7 GO:0007608 sensory perception of smell(GO:0007608)
0.0 2.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.2 1.2 GO:0019532 oxalate transport(GO:0019532)
0.1 1.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.2 0.9 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.9 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.9 GO:0006270 DNA replication initiation(GO:0006270)
0.1 0.8 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.8 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.7 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.6 GO:0033194 response to hydroperoxide(GO:0033194)
0.1 0.5 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.5 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.5 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.4 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.1 0.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.4 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.6 GO:0070469 respiratory chain(GO:0070469)
0.0 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.7 GO:0051286 cell tip(GO:0051286)
0.0 0.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.6 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 0.6 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)
0.1 0.5 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.3 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.3 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.2 GO:0097487 vesicle lumen(GO:0031983) multivesicular body, internal vesicle(GO:0097487)
0.0 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.6 3.6 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 3.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.2 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.9 GO:0043422 protein kinase B binding(GO:0043422)
0.1 0.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 0.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.1 0.5 GO:0000150 recombinase activity(GO:0000150)
0.0 0.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.4 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 0.4 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 0.4 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 0.3 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.3 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.3 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.7 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.5 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.2 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway