Motif ID: Nanog

Z-value: 0.613


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.145.9e-01Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 1.442 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_41273977 1.293 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chrY_-_1245685 1.240 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr18_-_35215008 1.111 ENSMUST00000091636.3
 Lrrtm2
leucine rich repeat transmembrane neuronal 2
chr2_+_134786154 0.979 ENSMUST00000110116.1
 Plcb1
phospholipase C, beta 1
chr17_-_81649607 0.919 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr7_+_49246131 0.861 ENSMUST00000064395.6
 Nav2
neuron navigator 2
chr6_+_80018877 0.855 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4



chr17_+_3397189 0.723 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr17_+_46297406 0.714 ENSMUST00000061722.6
ENSMUST00000166280.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr18_-_78206408 0.678 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr6_+_80019008 0.673 ENSMUST00000126399.1
ENSMUST00000136421.1
 Lrrtm4

leucine rich repeat transmembrane neuronal 4

chrX_+_153237466 0.661 ENSMUST00000143880.1
 Klf8
Kruppel-like factor 8
chr3_+_62419668 0.622 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr7_-_63212514 0.604 ENSMUST00000032738.5
 Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
chr7_+_128688480 0.585 ENSMUST00000118605.1
 Inpp5f
inositol polyphosphate-5-phosphatase F
chr1_-_52490736 0.543 ENSMUST00000170269.1
 Nab1
Ngfi-A binding protein 1
chr9_-_15357692 0.531 ENSMUST00000098979.3
ENSMUST00000161132.1
 5830418K08Rik

RIKEN cDNA 5830418K08 gene

chr14_-_78536762 0.526 ENSMUST00000123853.1
 Akap11
A kinase (PRKA) anchor protein 11
chr1_+_169655493 0.471 ENSMUST00000027997.3
 Rgs5
regulator of G-protein signaling 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.4 1.6 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)
0.0 1.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 1.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 1.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.2 0.9 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.2 0.9 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.2 0.9 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.9 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.2 0.8 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.8 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.2 0.7 GO:0071918 urea transmembrane transport(GO:0071918)
0.2 0.6 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978)
0.0 0.6 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.6 GO:0015807 L-amino acid transport(GO:0015807)
0.1 0.5 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1 0.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.5 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.5 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 0.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0030315 T-tubule(GO:0030315)
0.0 1.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 0.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 0.8 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.4 GO:0071565 nBAF complex(GO:0071565)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.3 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 0.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 1.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.0 GO:0005521 lamin binding(GO:0005521)
0.2 0.9 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.0 0.8 GO:0051787 misfolded protein binding(GO:0051787)
0.1 0.7 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.6 GO:0052833 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 0.6 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 0.4 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.4 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.0 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 0.9 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.0 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.9 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.8 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 0.6 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.0 0.5 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)