Motif ID: Hmx1
Z-value: 0.761
Transcription factors associated with Hmx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hmx1 | ENSMUSG00000067438.3 | Hmx1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | GO:0070650 | actin filament bundle distribution(GO:0070650) |
| 0.5 | 1.5 | GO:0072382 | minus-end-directed vesicle transport along microtubule(GO:0072382) |
| 0.5 | 1.5 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
| 0.4 | 1.1 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.3 | 1.3 | GO:1901492 | positive regulation of lymphangiogenesis(GO:1901492) |
| 0.3 | 0.9 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.3 | 0.8 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 0.2 | 1.6 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.2 | 1.3 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.2 | 0.6 | GO:0060010 | Sertoli cell fate commitment(GO:0060010) |
| 0.2 | 0.3 | GO:0006990 | positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990) |
| 0.2 | 0.5 | GO:0070889 | platelet alpha granule organization(GO:0070889) |
| 0.2 | 1.4 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.1 | 2.7 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.1 | 0.7 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.1 | 0.4 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 1.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.1 | 0.8 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
| 0.1 | 0.7 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 1.7 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.1 | 1.2 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.1 | 0.8 | GO:0032439 | endosome localization(GO:0032439) |
| 0.1 | 0.6 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) |
| 0.1 | 0.7 | GO:1904426 | positive regulation of GTP binding(GO:1904426) |
| 0.1 | 0.8 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 0.7 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.1 | 0.4 | GO:2001137 | positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953) positive regulation of endocytic recycling(GO:2001137) |
| 0.1 | 0.5 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.1 | 0.6 | GO:0046549 | phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549) |
| 0.1 | 0.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 0.4 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.1 | 0.4 | GO:0090370 | negative regulation of cholesterol efflux(GO:0090370) |
| 0.1 | 0.7 | GO:0006560 | proline metabolic process(GO:0006560) |
| 0.1 | 0.4 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 0.1 | 0.2 | GO:1905034 | regulation of antifungal innate immune response(GO:1905034) negative regulation of antifungal innate immune response(GO:1905035) |
| 0.1 | 0.4 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.1 | 0.7 | GO:2000270 | negative regulation of fibroblast apoptotic process(GO:2000270) |
| 0.1 | 0.3 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.1 | 0.7 | GO:0007042 | lysosomal lumen acidification(GO:0007042) |
| 0.1 | 0.4 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 1.1 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 1.3 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 0.1 | 0.3 | GO:0031133 | cellular magnesium ion homeostasis(GO:0010961) regulation of axon diameter(GO:0031133) |
| 0.1 | 0.2 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.1 | 0.3 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.1 | 0.3 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.1 | 0.3 | GO:1990839 | response to endothelin(GO:1990839) |
| 0.0 | 0.2 | GO:0036006 | response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006) |
| 0.0 | 0.2 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.0 | 1.3 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.0 | 0.3 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.0 | 0.7 | GO:0045723 | positive regulation of fatty acid biosynthetic process(GO:0045723) |
| 0.0 | 0.3 | GO:0051004 | plasma membrane to endosome transport(GO:0048227) regulation of lipoprotein lipase activity(GO:0051004) |
| 0.0 | 0.2 | GO:1902525 | regulation of protein monoubiquitination(GO:1902525) |
| 0.0 | 0.9 | GO:0010883 | regulation of lipid storage(GO:0010883) |
| 0.0 | 0.2 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.0 | 0.7 | GO:0032463 | negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.1 | GO:0015744 | succinate transport(GO:0015744) |
| 0.0 | 0.4 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.1 | GO:0016240 | autophagosome docking(GO:0016240) |
| 0.0 | 0.3 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
| 0.0 | 0.4 | GO:0072600 | establishment of protein localization to Golgi(GO:0072600) |
| 0.0 | 1.9 | GO:0048747 | muscle fiber development(GO:0048747) |
| 0.0 | 0.4 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.0 | 0.5 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
| 0.0 | 0.6 | GO:0032402 | melanosome transport(GO:0032402) anagen(GO:0042640) |
| 0.0 | 0.1 | GO:0072053 | trachea cartilage morphogenesis(GO:0060535) renal inner medulla development(GO:0072053) renal outer medulla development(GO:0072054) |
| 0.0 | 1.3 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 0.7 | GO:0043277 | apoptotic cell clearance(GO:0043277) |
| 0.0 | 0.2 | GO:0033031 | positive regulation of neutrophil apoptotic process(GO:0033031) |
| 0.0 | 0.3 | GO:0000963 | mitochondrial RNA processing(GO:0000963) |
| 0.0 | 0.8 | GO:0003016 | respiratory system process(GO:0003016) |
| 0.0 | 0.4 | GO:0080182 | histone H3-K4 trimethylation(GO:0080182) |
| 0.0 | 0.2 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.0 | 0.2 | GO:0061084 | negative regulation of protein refolding(GO:0061084) |
| 0.0 | 0.3 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 0.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.3 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.0 | 0.2 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.0 | 0.1 | GO:0043328 | protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) |
| 0.0 | 0.1 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.0 | 1.5 | GO:0032526 | response to retinoic acid(GO:0032526) |
| 0.0 | 0.1 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.0 | 1.4 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.1 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.0 | 0.3 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.0 | 0.6 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.0 | 0.5 | GO:0045879 | negative regulation of smoothened signaling pathway(GO:0045879) |
| 0.0 | 0.0 | GO:0002329 | pre-B cell differentiation(GO:0002329) |
| 0.0 | 2.2 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 0.4 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
| 0.0 | 0.5 | GO:0051930 | regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931) |
| 0.0 | 0.2 | GO:0045216 | cell-cell junction organization(GO:0045216) |
| 0.0 | 0.3 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 0.0 | 0.1 | GO:0090503 | histone mRNA catabolic process(GO:0071044) RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.0 | 0.3 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.9 | GO:0008584 | male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.7 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.3 | 1.6 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.2 | 0.7 | GO:0044299 | C-fiber(GO:0044299) |
| 0.2 | 1.1 | GO:0031523 | Myb complex(GO:0031523) |
| 0.2 | 1.2 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.2 | 0.9 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.1 | 0.7 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.1 | 0.8 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 1.3 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.7 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 1.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 1.7 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 0.7 | GO:0005775 | vacuolar lumen(GO:0005775) |
| 0.1 | 0.4 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.3 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 0.8 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 0.3 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.1 | 0.3 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.1 | 0.4 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 0.3 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.0 | 0.1 | GO:0097629 | extrinsic component of omegasome membrane(GO:0097629) |
| 0.0 | 3.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.4 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 2.0 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 2.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 1.3 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.3 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.1 | GO:0000814 | ESCRT II complex(GO:0000814) |
| 0.0 | 0.2 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.0 | 0.3 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.0 | 0.4 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.0 | 0.4 | GO:0097228 | sperm midpiece(GO:0097225) sperm principal piece(GO:0097228) |
| 0.0 | 0.3 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 0.7 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.5 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.0 | 0.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.0 | 0.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 0.2 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 1.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.7 | GO:0031519 | PcG protein complex(GO:0031519) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.0 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.4 | 1.2 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 0.3 | 1.1 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.2 | 1.3 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 0.8 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.2 | 0.7 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.2 | 0.5 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 0.1 | 0.4 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.1 | 0.4 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 0.8 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.1 | 0.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 1.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 1.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.5 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 0.3 | GO:0019966 | interleukin-1 binding(GO:0019966) |
| 0.1 | 1.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 0.3 | GO:0016901 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 0.1 | 0.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 0.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.1 | 0.4 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 0.3 | GO:0001537 | N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537) |
| 0.1 | 0.3 | GO:0048408 | epidermal growth factor binding(GO:0048408) |
| 0.1 | 0.2 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 0.1 | 0.3 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.1 | 0.7 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 0.4 | GO:0004645 | phosphorylase activity(GO:0004645) |
| 0.1 | 1.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.3 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.5 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 1.4 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 0.3 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.0 | 0.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.4 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.0 | 0.1 | GO:0015140 | malate transmembrane transporter activity(GO:0015140) |
| 0.0 | 0.6 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.3 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.0 | 0.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.4 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.3 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.0 | 0.7 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.2 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 0.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.0 | 0.6 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.7 | GO:0071949 | FAD binding(GO:0071949) |
| 0.0 | 2.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.2 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.0 | 0.2 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.7 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.0 | 0.4 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.1 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.0 | 1.0 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.2 | GO:1990829 | C-rich single-stranded DNA binding(GO:1990829) |
| 0.0 | 0.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 0.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.5 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.2 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.0 | 0.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.3 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 0.4 | GO:0015036 | disulfide oxidoreductase activity(GO:0015036) |
| 0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.2 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 0.1 | GO:0001165 | RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165) |
| 0.0 | 0.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.0 | GO:0004816 | asparagine-tRNA ligase activity(GO:0004816) |
| 0.0 | 0.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.1 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.0 | 0.2 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.7 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 0.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 2.2 | GO:0001047 | core promoter binding(GO:0001047) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.3 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 3.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.3 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 1.4 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 2.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.9 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.9 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.8 | PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.0 | 0.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.7 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.5 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 0.4 | PID_S1P_S1P3_PATHWAY | S1P3 pathway |
| 0.0 | 0.6 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.3 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.4 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.4 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.2 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.9 | PID_E2F_PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 1.3 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 0.9 | REACTOME_KERATAN_SULFATE_DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 2.5 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 1.5 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 0.6 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 1.4 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.2 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.6 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 0.4 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 1.4 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.6 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.5 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 1.3 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.8 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 1.5 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.3 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 1.7 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 0.2 | REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.3 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.1 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.3 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.9 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.6 | REACTOME_CELL_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.0 | 0.2 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.4 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.2 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.6 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
