Motif ID: Hmx1

Z-value: 0.761


Transcription factors associated with Hmx1:

Gene SymbolEntrez IDGene Name
Hmx1 ENSMUSG00000067438.3 Hmx1



Activity profile for motif Hmx1.

activity profile for motif Hmx1


Sorted Z-values histogram for motif Hmx1

Sorted Z-values for motif Hmx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_164562579 2.043 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr10_-_77113676 1.829 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr6_-_127151044 1.691 ENSMUST00000000188.8
 Ccnd2
cyclin D2
chr7_-_144939823 1.637 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr7_-_48881032 1.527 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr17_-_23684019 1.463 ENSMUST00000085989.5
 Cldn9
claudin 9
chr19_+_25610533 1.394 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr1_+_52008210 1.393 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr2_+_168081004 1.390 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr1_-_172057573 1.353 ENSMUST00000059794.3
 Nhlh1
nescient helix loop helix 1
chr12_+_109459843 1.316 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr7_-_116308241 1.304 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr8_+_54077532 1.275 ENSMUST00000033919.4
 Vegfc
vascular endothelial growth factor C
chr5_+_114568016 1.227 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr1_-_165194310 1.201 ENSMUST00000043338.4
 Sft2d2
SFT2 domain containing 2
chr6_-_95718800 1.155 ENSMUST00000079847.5
 Suclg2
succinate-Coenzyme A ligase, GDP-forming, beta subunit
chr14_+_7817957 1.122 ENSMUST00000052678.8
 Flnb
filamin, beta
chr2_+_165595009 1.104 ENSMUST00000088132.6
 Eya2
eyes absent 2 homolog (Drosophila)
chr6_+_30738044 0.932 ENSMUST00000128398.1
ENSMUST00000163949.2
ENSMUST00000124665.1
 Mest


mesoderm specific transcript


chr7_-_126160992 0.927 ENSMUST00000164741.1
 Xpo6
exportin 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 2.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.9 GO:0048747 muscle fiber development(GO:0048747)
0.1 1.7 GO:0071481 cellular response to X-ray(GO:0071481)
0.5 1.6 GO:0070650 actin filament bundle distribution(GO:0070650)
0.2 1.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.5 1.5 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.5 1.5 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.0 1.5 GO:0032526 response to retinoic acid(GO:0032526)
0.2 1.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 1.4 GO:0006611 protein export from nucleus(GO:0006611)
0.3 1.3 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.2 1.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 1.3 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 1.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 1.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.2 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.4 1.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 1.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.1 1.1 GO:0003334 keratinocyte development(GO:0003334)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.0 2.1 GO:0005871 kinesin complex(GO:0005871)
0.0 2.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 1.7 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 1.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 1.6 GO:0097513 myosin II filament(GO:0097513)
0.0 1.5 GO:0016528 sarcoplasm(GO:0016528)
0.1 1.3 GO:0005915 zonula adherens(GO:0005915)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 1.2 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 1.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 1.1 GO:0031523 Myb complex(GO:0031523)
0.0 1.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.8 GO:0045179 apical cortex(GO:0045179)
0.1 0.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.2 0.7 GO:0044299 C-fiber(GO:0044299)
0.1 0.7 GO:0030314 junctional membrane complex(GO:0030314)
0.1 0.7 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.7 GO:0005775 vacuolar lumen(GO:0005775)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0001047 core promoter binding(GO:0001047)
0.0 2.1 GO:0003777 microtubule motor activity(GO:0003777)
0.4 2.0 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 1.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.5 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.4 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.4 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.3 GO:0043426 MRF binding(GO:0043426)
0.4 1.2 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.3 1.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 1.0 GO:0003774 motor activity(GO:0003774)
0.0 0.9 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 0.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.8 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 0.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 1.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 1.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.8 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.4 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 2.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.4 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 1.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.3 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.2 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 0.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 0.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 0.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway