Motif ID: Esr1

Z-value: 0.599


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4710119_47101660.194.5e-01Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_30973399 1.584 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr7_-_30973367 1.460 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973464 1.430 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr10_-_77113676 1.337 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr4_+_124986430 1.255 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr2_-_166155272 1.080 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr14_-_98169542 1.034 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr9_+_54764748 0.938 ENSMUST00000034830.8
 Crabp1
cellular retinoic acid binding protein I
chr1_-_175692624 0.921 ENSMUST00000027809.7
 Opn3
opsin 3
chr9_+_62858085 0.908 ENSMUST00000034777.6
ENSMUST00000163820.1
 Calml4

calmodulin-like 4

chr2_+_122147680 0.898 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr11_-_115612491 0.896 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr2_+_27886416 0.881 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr9_+_123366921 0.873 ENSMUST00000038863.7
 Lars2
leucyl-tRNA synthetase, mitochondrial
chr12_+_109747903 0.853 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr18_+_74442500 0.847 ENSMUST00000074157.6
 Myo5b
myosin VB
chr10_-_120899067 0.845 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr18_+_74442551 0.823 ENSMUST00000121875.1
 Myo5b
myosin VB
chr6_+_66535390 0.811 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr16_+_17489639 0.770 ENSMUST00000023448.6
 Aifm3
apoptosis-inducing factor, mitochondrion-associated 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 4.5 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.5 1.9 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.3 1.7 GO:0032439 endosome localization(GO:0032439)
0.1 1.7 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.2 1.5 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.3 1.4 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.1 1.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.4 1.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.4 1.2 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.3 1.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.1 GO:0050849 negative regulation of calcium-mediated signaling(GO:0050849)
0.0 1.1 GO:0043039 tRNA aminoacylation(GO:0043039)
0.3 1.0 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.3 1.0 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3 1.0 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.2 1.0 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 1.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.0 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 1.0 GO:0097194 execution phase of apoptosis(GO:0097194)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.5 GO:0061689 tricellular tight junction(GO:0061689)
0.4 2.5 GO:0097452 GAIT complex(GO:0097452)
0.0 2.0 GO:0005581 collagen trimer(GO:0005581)
0.1 1.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.3 1.7 GO:0045179 apical cortex(GO:0045179)
0.0 1.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.2 GO:0061574 ASAP complex(GO:0061574)
0.0 1.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 1.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.3 0.9 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 0.8 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.7 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 0.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.2 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 1.9 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.1 1.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 1.7 GO:0003774 motor activity(GO:0003774)
0.4 1.2 GO:0009881 photoreceptor activity(GO:0009881)
0.1 1.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.2 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 1.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.2 1.0 GO:0043199 Ran guanyl-nucleotide exchange factor activity(GO:0005087) sulfate binding(GO:0043199)
0.2 1.0 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.0 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 1.0 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.0 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.9 GO:0019841 retinol binding(GO:0019841)
0.1 0.9 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.2 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.1 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.0 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.7 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.7 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.2 PID_EPO_PATHWAY EPO signaling pathway
0.0 0.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.2 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 2.2 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 1.9 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.1 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.1 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.0 REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS Genes involved in Host Interactions of HIV factors
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 0.6 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins