Motif ID: Klf12_Klf14_Sp4

Z-value: 0.586

Transcription factors associated with Klf12_Klf14_Sp4:

Gene SymbolEntrez IDGene Name
Klf12 ENSMUSG00000072294.4 Klf12
Klf14 ENSMUSG00000073209.3 Klf14
Sp4 ENSMUSG00000025323.9 Sp4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp4mm10_v2_chr12_-_118301429_118301458-0.321.9e-01Click!
Klf12mm10_v2_chr14_-_100149764_100149764-0.107.1e-01Click!


Activity profile for motif Klf12_Klf14_Sp4.

activity profile for motif Klf12_Klf14_Sp4


Sorted Z-values histogram for motif Klf12_Klf14_Sp4

Sorted Z-values for motif Klf12_Klf14_Sp4



Network of associatons between targets according to the STRING database.



First level regulatory network of Klf12_Klf14_Sp4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_25622525 0.965 ENSMUST00000110457.1
ENSMUST00000137601.1
 Myo10

myosin X

chr4_+_137468767 0.791 ENSMUST00000030547.8
ENSMUST00000171332.1
 Hspg2

perlecan (heparan sulfate proteoglycan 2)

chr14_+_60634719 0.772 ENSMUST00000022566.7
ENSMUST00000159729.1
 Spata13

spermatogenesis associated 13

chr5_-_113908685 0.705 ENSMUST00000004646.6
 Coro1c
coronin, actin binding protein 1C
chr5_-_99252839 0.665 ENSMUST00000168092.1
ENSMUST00000031276.8
 Rasgef1b

RasGEF domain family, member 1B

chr11_+_78322965 0.649 ENSMUST00000017534.8
 Aldoc
aldolase C, fructose-bisphosphate
chr12_+_108334341 0.604 ENSMUST00000021684.4
 Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr5_-_144358103 0.574 ENSMUST00000055190.7
 Baiap2l1
BAI1-associated protein 2-like 1
chr9_+_80165079 0.468 ENSMUST00000184480.1
 Myo6
myosin VI
chr17_+_57249450 0.465 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10
chrY_+_897782 0.454 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr9_-_21798502 0.454 ENSMUST00000034717.5
 Kank2
KN motif and ankyrin repeat domains 2
chr9_-_21852603 0.452 ENSMUST00000034728.7
 Dock6
dedicator of cytokinesis 6
chr6_+_29396576 0.450 ENSMUST00000115275.1
 Ccdc136
coiled-coil domain containing 136
chr6_+_29396665 0.446 ENSMUST00000096084.5
 Ccdc136
coiled-coil domain containing 136
chr10_-_59951753 0.438 ENSMUST00000020308.3
 Ddit4
DNA-damage-inducible transcript 4
chr2_+_79635352 0.427 ENSMUST00000111785.2
 Ssfa2
sperm specific antigen 2
chr5_-_140389188 0.424 ENSMUST00000031539.7
 Snx8
sorting nexin 8
chr5_+_135689036 0.418 ENSMUST00000005651.6
ENSMUST00000122113.1
 Por

P450 (cytochrome) oxidoreductase

chr9_+_80165013 0.406 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 392 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0001675 acrosome assembly(GO:0001675)
0.1 1.0 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.1 1.0 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.0 0.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 0.7 GO:0015888 thiamine transport(GO:0015888)
0.1 0.7 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 0.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.6 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.6 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.6 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.2 0.5 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.1 0.5 GO:0046210 nitrate catabolic process(GO:0043602) nitric oxide catabolic process(GO:0046210) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.1 0.5 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.1 0.5 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.5 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 0.5 GO:0015074 DNA integration(GO:0015074)
0.0 0.5 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.5 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0016459 myosin complex(GO:0016459)
0.0 1.3 GO:0030175 filopodium(GO:0030175)
0.1 0.8 GO:0016600 flotillin complex(GO:0016600)
0.0 0.8 GO:0005605 basal lamina(GO:0005605)
0.0 0.7 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.5 GO:0016011 dystroglycan complex(GO:0016011)
0.0 0.5 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.3 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.3 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.3 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 234 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 0.7 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.6 GO:0008802 betaine-aldehyde dehydrogenase activity(GO:0008802)
0.1 0.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 0.5 GO:0016708 nitric oxide dioxygenase activity(GO:0008941) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor(GO:0016708) iron-cytochrome-c reductase activity(GO:0047726)
0.1 0.5 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.1 0.5 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.1 0.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.1 0.5 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.5 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.5 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.4 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.1 0.4 GO:1990188 euchromatin binding(GO:1990188)
0.1 0.4 GO:0008242 omega peptidase activity(GO:0008242)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.1 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.7 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.6 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 0.5 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.3 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.3 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.0 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.8 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.7 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.7 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 0.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.5 REACTOME_BASE_EXCISION_REPAIR Genes involved in Base Excision Repair
0.0 0.5 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1