Motif ID: Tcf7l1
Z-value: 1.139
Transcription factors associated with Tcf7l1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tcf7l1 | ENSMUSG00000055799.7 | Tcf7l1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tcf7l1 | mm10_v2_chr6_-_72788952_72789061 | 0.78 | 1.3e-04 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 114 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 6.2 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 1.3 | 4.0 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) |
| 1.2 | 3.7 | GO:0060244 | negative regulation of cell proliferation involved in contact inhibition(GO:0060244) |
| 0.5 | 3.4 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.2 | 3.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.2 | 3.1 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.1 | 2.6 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.2 | 2.3 | GO:0060481 | lobar bronchus epithelium development(GO:0060481) |
| 0.1 | 2.1 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.1 | 2.0 | GO:0048368 | lateral mesoderm development(GO:0048368) |
| 0.2 | 1.9 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.0 | 1.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 1.9 | GO:0034766 | negative regulation of ion transmembrane transport(GO:0034766) |
| 0.6 | 1.8 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.6 | 1.7 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
| 0.3 | 1.7 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
| 0.2 | 1.7 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.2 | 1.6 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.2 | 1.6 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 45 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.4 | 4.5 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.7 | 2.0 | GO:0071149 | TEAD-2-YAP complex(GO:0071149) |
| 0.2 | 1.8 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 1.7 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 1.7 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.1 | 1.6 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.0 | 1.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.4 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 1.4 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.4 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.3 | 1.3 | GO:0008623 | CHRAC(GO:0008623) |
| 0.2 | 1.2 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.1 | 1.2 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 1.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.0 | GO:0031105 | septin complex(GO:0031105) |
| 0.3 | 0.9 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.0 | 0.9 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 0.8 | GO:0005726 | perichromatin fibrils(GO:0005726) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 82 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.2 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.7 | 4.0 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.5 | 3.7 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.2 | 3.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 3.2 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 1.0 | 3.1 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.0 | 3.1 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 2.8 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 2.6 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 2.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 2.1 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.0 | 2.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 1.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.0 | 1.7 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.1 | 1.6 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.1 | 1.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 1.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 1.6 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.4 | 1.5 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.3 | 1.4 | GO:0005113 | patched binding(GO:0005113) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 28 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 5.4 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 3.9 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.3 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.8 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.0 | 1.7 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 1.6 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.5 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.3 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.2 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 1.1 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 1.0 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.8 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.8 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.7 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.7 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID_MTOR_4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.6 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.5 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 31 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.7 | REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 3.5 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 2.9 | REACTOME_SIGNALING_BY_FGFR | Genes involved in Signaling by FGFR |
| 0.0 | 2.8 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.2 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 2.1 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 1.5 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 1.3 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 1.2 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.2 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.0 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 0.8 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.7 | REACTOME_REGULATION_OF_KIT_SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 0.7 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.7 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.7 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.6 | REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 0.4 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
