Motif ID: Sox17

Z-value: 0.558


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496400_4496420-0.522.9e-02Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 3.304 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_52008210 1.764 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr11_-_97775876 1.094 ENSMUST00000107576.1
 1700001P01Rik
RIKEN cDNA 1700001P01 gene
chr14_+_50944499 1.044 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr2_-_180889660 1.011 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr8_-_105471481 1.002 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr10_-_128176568 0.731 ENSMUST00000092033.2
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_+_85205949 0.658 ENSMUST00000057410.7
ENSMUST00000109432.3
 Fbln1

fibulin 1

chr19_+_55741810 0.651 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr6_-_148944750 0.644 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr10_+_11609256 0.623 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr9_+_66946057 0.610 ENSMUST00000040917.7
ENSMUST00000127896.1
 Rps27l

ribosomal protein S27-like

chr12_+_24708241 0.576 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr15_+_74721193 0.539 ENSMUST00000070923.1
 Them6
thioesterase superfamily member 6
chr2_-_127133909 0.489 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr8_+_4248188 0.461 ENSMUST00000110993.1
 Gm14378
predicted gene 14378
chr2_+_181187247 0.456 ENSMUST00000016488.6
ENSMUST00000108841.1
 Ppdpf

pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)RIKEN cDNA 2700038C09 gene

chr14_+_31134853 0.446 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr2_+_121456963 0.442 ENSMUST00000126764.1
 Hypk
huntingtin interacting protein K
chr4_-_42773993 0.418 ENSMUST00000095114.4
 Ccl21a
chemokine (C-C motif) ligand 21A (serine)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.0 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 0.8 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.2 0.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) transforming growth factor-beta secretion(GO:0038044) blood coagulation, fibrin clot formation(GO:0072378)
0.1 0.7 GO:0048625 myoblast fate commitment(GO:0048625)
0.0 0.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 0.5 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.5 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.4 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.0 0.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1 0.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.3 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 0.3 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.1 0.2 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 0.2 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.8 GO:0051233 spindle midzone(GO:0051233)
0.2 0.7 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.5 GO:0000799 nuclear condensin complex(GO:0000799)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 1.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.7 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.7 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 0.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 0.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.2 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.2 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling