Motif ID: Sox17

Z-value: 0.558


Transcription factors associated with Sox17:

Gene SymbolEntrez IDGene Name
Sox17 ENSMUSG00000025902.7 Sox17

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox17mm10_v2_chr1_-_4496400_4496420-0.522.9e-02Click!


Activity profile for motif Sox17.

activity profile for motif Sox17


Sorted Z-values histogram for motif Sox17

Sorted Z-values for motif Sox17



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox17

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 3.304 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_+_52008210 1.764 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4
chr11_-_97775876 1.094 ENSMUST00000107576.1
 1700001P01Rik
RIKEN cDNA 1700001P01 gene
chr14_+_50944499 1.044 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr2_-_180889660 1.011 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr8_-_105471481 1.002 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr10_-_128176568 0.731 ENSMUST00000092033.2
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_+_85205949 0.658 ENSMUST00000057410.7
ENSMUST00000109432.3
 Fbln1

fibulin 1

chr19_+_55741810 0.651 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr6_-_148944750 0.644 ENSMUST00000111562.1
ENSMUST00000081956.5
 Fam60a

family with sequence similarity 60, member A

chr10_+_11609256 0.623 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr9_+_66946057 0.610 ENSMUST00000040917.7
ENSMUST00000127896.1
 Rps27l

ribosomal protein S27-like

chr12_+_24708241 0.576 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr15_+_74721193 0.539 ENSMUST00000070923.1
 Them6
thioesterase superfamily member 6
chr2_-_127133909 0.489 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr8_+_4248188 0.461 ENSMUST00000110993.1
 Gm14378
predicted gene 14378
chr2_+_181187247 0.456 ENSMUST00000016488.6
ENSMUST00000108841.1
 Ppdpf

pancreatic progenitor cell differentiation and proliferation factor homolog (zebrafish)RIKEN cDNA 2700038C09 gene

chr14_+_31134853 0.446 ENSMUST00000090212.4
 Nt5dc2
5'-nucleotidase domain containing 2
chr2_+_121456963 0.442 ENSMUST00000126764.1
 Hypk
huntingtin interacting protein K
chr4_-_42773993 0.418 ENSMUST00000095114.4
 Ccl21a
chemokine (C-C motif) ligand 21A (serine)
chr11_+_78346666 0.406 ENSMUST00000100755.3
 Unc119
unc-119 homolog (C. elegans)
chr15_+_27025386 0.399 ENSMUST00000169678.2
 Gm6576
predicted gene 6576
chr9_+_57521232 0.367 ENSMUST00000000090.6
 Cox5a
cytochrome c oxidase subunit Va
chr11_-_11970540 0.361 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr11_+_78343475 0.356 ENSMUST00000002127.7
ENSMUST00000108295.1
 Unc119

unc-119 homolog (C. elegans)

chr10_+_80249106 0.354 ENSMUST00000105364.1
 Ndufs7
NADH dehydrogenase (ubiquinone) Fe-S protein 7
chr7_+_29238323 0.352 ENSMUST00000108238.1
ENSMUST00000032809.3
ENSMUST00000138128.1
 Yif1b


Yip1 interacting factor homolog B (S. cerevisiae)


chr4_+_41903610 0.346 ENSMUST00000098128.3
 Gm21541
predicted gene, 21541
chr10_+_93453382 0.325 ENSMUST00000016033.7
 Lta4h
leukotriene A4 hydrolase
chr10_+_14523062 0.320 ENSMUST00000096020.5
 Gm10335
predicted gene 10335
chr8_-_102865853 0.320 ENSMUST00000076373.6
 Gm8730
predicted pseudogene 8730
chrX_+_48695004 0.308 ENSMUST00000033433.2
 Rbmx2
RNA binding motif protein, X-linked 2
chr6_+_121245903 0.288 ENSMUST00000032198.9
 Usp18
ubiquitin specific peptidase 18
chr11_-_106388066 0.273 ENSMUST00000106813.2
ENSMUST00000141146.1
 Icam2

intercellular adhesion molecule 2

chr2_+_155751117 0.269 ENSMUST00000029140.5
ENSMUST00000132608.1
 Procr

protein C receptor, endothelial

chr2_+_18677002 0.269 ENSMUST00000028071.6
 Bmi1
Bmi1 polycomb ring finger oncogene
chr2_-_57113053 0.268 ENSMUST00000112627.1
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr13_+_54071815 0.260 ENSMUST00000021930.8
 Sfxn1
sideroflexin 1
chr14_+_54426902 0.249 ENSMUST00000010550.7
 Mrpl52
mitochondrial ribosomal protein L52
chr11_-_86807624 0.246 ENSMUST00000018569.7
 Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr7_+_29238434 0.245 ENSMUST00000108237.1
 Yif1b
Yip1 interacting factor homolog B (S. cerevisiae)
chr5_-_123721007 0.241 ENSMUST00000031376.7
 Zcchc8
zinc finger, CCHC domain containing 8
chr2_-_121456693 0.235 ENSMUST00000110613.2
ENSMUST00000056312.3
 Serinc4

serine incorporator 4

chr15_-_96460838 0.229 ENSMUST00000047835.6
 Scaf11
SR-related CTD-associated factor 11
chr4_-_135971894 0.219 ENSMUST00000105852.1
 Lypla2
lysophospholipase 2
chr8_+_69822429 0.214 ENSMUST00000164890.1
ENSMUST00000034325.4
 Lpar2

lysophosphatidic acid receptor 2

chr5_-_107597577 0.203 ENSMUST00000100949.3
ENSMUST00000078021.6
 Glmn

glomulin, FKBP associated protein

chr7_-_100656953 0.200 ENSMUST00000107046.1
ENSMUST00000107045.1
ENSMUST00000139708.1
 Plekhb1


pleckstrin homology domain containing, family B (evectins) member 1


chr12_+_84970897 0.199 ENSMUST00000021669.8
ENSMUST00000171040.1
 Fcf1

FCF1 small subunit (SSU) processome component homolog (S. cerevisiae)

chr8_-_111854278 0.197 ENSMUST00000034432.5
 Cfdp1
craniofacial development protein 1
chr7_+_97400003 0.195 ENSMUST00000032882.8
 Ndufc2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr14_+_73142591 0.193 ENSMUST00000170368.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr1_+_135729147 0.186 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr18_+_35599219 0.185 ENSMUST00000115734.1
 Paip2
polyadenylate-binding protein-interacting protein 2
chr19_+_8920358 0.179 ENSMUST00000096243.5
 B3gat3
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr18_-_33213832 0.179 ENSMUST00000025236.2
 Stard4
StAR-related lipid transfer (START) domain containing 4
chr6_+_83034173 0.176 ENSMUST00000000707.2
ENSMUST00000101257.3
 Loxl3

lysyl oxidase-like 3

chr18_-_36197343 0.173 ENSMUST00000115713.1
ENSMUST00000115712.1
 Nrg2

neuregulin 2

chr14_+_73142490 0.133 ENSMUST00000170370.1
ENSMUST00000164822.1
ENSMUST00000165429.1
 Rcbtb2


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2


chr7_+_126976338 0.131 ENSMUST00000032920.3
 Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr11_-_51606840 0.123 ENSMUST00000074669.3
ENSMUST00000101249.2
ENSMUST00000109103.3
 Hnrnpab


heterogeneous nuclear ribonucleoprotein A/B


chr18_+_60560730 0.123 ENSMUST00000025506.6
 Rbm22
RNA binding motif protein 22
chr9_+_50494516 0.122 ENSMUST00000114474.1
 1600029D21Rik
RIKEN cDNA 1600029D21 gene
chr8_+_107150621 0.086 ENSMUST00000034400.3
 Cyb5b
cytochrome b5 type B
chr2_-_142901506 0.083 ENSMUST00000043589.7
 Kif16b
kinesin family member 16B
chr11_-_77894096 0.081 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr8_-_94098811 0.071 ENSMUST00000034206.4
 Bbs2
Bardet-Biedl syndrome 2 (human)
chr3_-_153725062 0.068 ENSMUST00000064460.5
 St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr13_-_35027077 0.067 ENSMUST00000170538.1
ENSMUST00000163280.1
 Eci2

enoyl-Coenzyme A delta isomerase 2

chr17_+_46428930 0.065 ENSMUST00000024764.5
ENSMUST00000165993.1
 Crip3

cysteine-rich protein 3

chr5_-_130002838 0.061 ENSMUST00000111308.1
ENSMUST00000111307.1
 Gusb

glucuronidase, beta

chr9_+_82829806 0.058 ENSMUST00000113245.2
ENSMUST00000034783.4
 Irak1bp1

interleukin-1 receptor-associated kinase 1 binding protein 1

chr5_-_38502107 0.057 ENSMUST00000005238.6
 Slc2a9
solute carrier family 2 (facilitated glucose transporter), member 9
chr5_-_107597533 0.037 ENSMUST00000124140.1
 Glmn
glomulin, FKBP associated protein
chr2_+_55411790 0.035 ENSMUST00000155997.1
ENSMUST00000128307.1
 Gm14033

predicted gene 14033

chrX_+_123103489 0.023 ENSMUST00000113343.1
 3110007F17Rik
RIKEN cDNA 3110007F17 gene
chr10_+_94575257 0.022 ENSMUST00000121471.1
 Tmcc3
transmembrane and coiled coil domains 3
chr2_+_80617045 0.017 ENSMUST00000028384.4
 Dusp19
dual specificity phosphatase 19
chr7_-_127890918 0.013 ENSMUST00000121394.1
 Prss53
protease, serine, 53
chr18_-_33213766 0.012 ENSMUST00000119991.1
ENSMUST00000118990.1
 Stard4

StAR-related lipid transfer (START) domain containing 4

chr7_-_104353328 0.012 ENSMUST00000130139.1
ENSMUST00000059037.8
 Trim12c

tripartite motif-containing 12C

chr4_+_138775735 0.010 ENSMUST00000030528.2
 Pla2g2d
phospholipase A2, group IID
chr7_-_143549055 0.003 ENSMUST00000072727.5
 Nap1l4
nucleosome assembly protein 1-like 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.0 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.2 0.7 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) transforming growth factor-beta secretion(GO:0038044) blood coagulation, fibrin clot formation(GO:0072378)
0.2 0.5 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.2 0.8 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286)
0.1 0.4 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.1 0.7 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 0.3 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1 0.3 GO:0051866 general adaptation syndrome(GO:0051866)
0.1 0.2 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0 0.2 GO:0070859 positive regulation of bile acid biosynthetic process(GO:0070859) positive regulation of bile acid metabolic process(GO:1904253)
0.0 0.3 GO:0019370 leukotriene biosynthetic process(GO:0019370)
0.0 0.1 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.4 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.2 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.2 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 0.3 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.0 0.2 GO:0050651 dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0 0.5 GO:0031017 exocrine pancreas development(GO:0031017)
0.0 0.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.2 GO:0045086 positive regulation of interleukin-2 biosynthetic process(GO:0045086)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0006553 lysine metabolic process(GO:0006553)
0.0 0.2 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.5 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0071953 fibrinogen complex(GO:0005577) elastic fiber(GO:0071953)
0.2 0.5 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 1.0 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.3 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.8 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.7 GO:0070051 fibrinogen binding(GO:0070051)
0.1 0.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.2 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.2 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.7 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 0.3 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 3.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.1 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_AURORA_B_PATHWAY Aurora B signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.3 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.3 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling