Motif ID: Mef2d_Mef2a

Z-value: 1.206

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2amm10_v2_chr7_-_67372846_673728580.881.5e-06Click!
Mef2dmm10_v2_chr3_+_88142328_881424830.551.8e-02Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 7.755 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr13_+_23934434 5.065 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr19_+_38264761 4.830 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr4_+_144892813 4.700 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_-_134234492 4.528 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr6_+_58831748 4.505 ENSMUST00000126292.1
ENSMUST00000031823.5
 Herc3

hect domain and RLD 3

chr3_-_56183678 4.215 ENSMUST00000029374.6
 Nbea
neurobeachin
chr1_-_64122256 4.190 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr6_-_136171722 4.134 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr5_+_75152274 3.948 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr7_+_91090697 3.931 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr9_-_112232449 3.900 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr11_+_31872100 3.848 ENSMUST00000020543.6
ENSMUST00000109412.2
 Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr7_+_91090728 3.828 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr4_+_144893077 3.605 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr13_-_113663670 3.522 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr16_+_45093611 3.463 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr16_+_7069825 3.432 ENSMUST00000056416.7
 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr15_+_101266839 3.333 ENSMUST00000023779.6
 Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr18_-_31949571 3.321 ENSMUST00000064016.5
 Gpr17
G protein-coupled receptor 17

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 10.9 GO:0042572 retinol metabolic process(GO:0042572)
2.6 7.8 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.6 7.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.0 6.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 6.2 GO:0001578 microtubule bundle formation(GO:0001578)
1.1 5.4 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 5.3 GO:0031032 actomyosin structure organization(GO:0031032)
1.5 4.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
1.5 4.5 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.1 4.5 GO:0034605 cellular response to heat(GO:0034605)
0.0 4.4 GO:0006342 chromatin silencing(GO:0006342)
1.0 4.1 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.8 4.1 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 4.1 GO:0048813 dendrite morphogenesis(GO:0048813)
0.0 4.0 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 4.0 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
1.3 3.9 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.5 3.8 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.6 3.5 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 3.5 GO:0032728 positive regulation of interferon-beta production(GO:0032728)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 GO:0016607 nuclear speck(GO:0016607)
0.4 7.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 7.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 7.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 6.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 5.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 5.2 GO:0001650 fibrillar center(GO:0001650)
0.0 5.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.2 GO:0016328 lateral plasma membrane(GO:0016328)
1.4 4.1 GO:0043512 inhibin A complex(GO:0043512)
0.3 4.1 GO:0043083 synaptic cleft(GO:0043083)
0.2 3.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 3.3 GO:0031965 nuclear membrane(GO:0031965)
0.8 3.2 GO:0090537 CERF complex(GO:0090537)
0.1 3.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 3.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 3.0 GO:0030054 cell junction(GO:0030054)
0.9 2.7 GO:0000802 transverse filament(GO:0000802)
0.3 2.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 2.4 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 11.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 7.8 GO:0035198 miRNA binding(GO:0035198)
0.3 7.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 7.2 GO:0008017 microtubule binding(GO:0008017)
1.1 6.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.1 6.5 GO:0070699 type II activin receptor binding(GO:0070699)
1.6 6.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 5.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.2 5.7 GO:0042805 actinin binding(GO:0042805)
0.6 4.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.2 4.5 GO:0030275 LRR domain binding(GO:0030275)
0.1 4.2 GO:0051018 protein kinase A binding(GO:0051018)
0.5 4.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 4.0 GO:0008083 growth factor activity(GO:0008083)
0.8 3.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 3.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 3.5 GO:0001968 fibronectin binding(GO:0001968)
1.1 3.2 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
0.1 3.0 GO:0030507 spectrin binding(GO:0030507)
0.1 2.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 7.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 4.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.1 PID_ALK1_PATHWAY ALK1 signaling events
0.1 4.1 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 3.8 PID_FGF_PATHWAY FGF signaling pathway
0.1 3.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.9 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.8 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 1.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.2 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.1 PID_P73PATHWAY p73 transcription factor network
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.3 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 6.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 4.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 4.6 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.4 4.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
1.0 4.1 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 3.9 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.1 3.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
1.1 3.3 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 3.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.1 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 3.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.5 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.7 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 1.3 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.2 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.2 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 1.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor