Motif ID: Foxc1

Z-value: 1.202


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.204.3e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 167 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_60144682 4.304 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr14_-_48662740 3.775 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr1_+_72824482 3.710 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_+_84839833 3.621 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr1_+_45311538 3.579 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr6_+_47244359 3.344 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr17_-_70851710 3.116 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chrX_-_102251852 2.981 ENSMUST00000101336.3
ENSMUST00000136277.1
 Cited1

Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

chr7_-_75308373 2.929 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr1_+_107511489 2.906 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 2.815 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chrX_-_102252154 2.701 ENSMUST00000050551.3
 Cited1
Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1
chr2_+_4976113 2.688 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr17_+_80944611 2.685 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr13_+_53525703 2.461 ENSMUST00000081132.4
 Gm5449
predicted pseudogene 5449
chrY_+_1010543 2.321 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr16_-_21947536 2.288 ENSMUST00000023562.7
 Tmem41a
transmembrane protein 41a
chrX_-_109013389 1.992 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5
chr10_+_77864623 1.951 ENSMUST00000092366.2
 Tspear
thrombospondin type laminin G domain and EAR repeats
chr3_+_94377432 1.833 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.7 GO:0071105 response to interleukin-9(GO:0071104) response to interleukin-11(GO:0071105)
0.0 5.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.9 3.8 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.2 3.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.7 3.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 3.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.4 3.3 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 3.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 2.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 2.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 2.7 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.3 2.1 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.2 2.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 2.0 GO:0007605 sensory perception of sound(GO:0007605)
0.0 1.9 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.6 1.8 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.6 1.8 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.1 1.8 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.7 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.5 1.6 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.9 GO:0005615 extracellular space(GO:0005615)
0.3 3.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 2.7 GO:0030673 axolemma(GO:0030673)
0.1 2.7 GO:0016235 aggresome(GO:0016235)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 2.1 GO:0032420 stereocilium(GO:0032420)
0.1 1.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 1.6 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.5 GO:0036064 ciliary basal body(GO:0036064)
0.5 1.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 1.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 1.4 GO:0016234 inclusion body(GO:0016234)
0.0 1.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.3 GO:0002080 acrosomal membrane(GO:0002080)
0.0 1.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 1.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 1.2 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 5.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.4 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 4.3 GO:0002020 protease binding(GO:0002020)
0.5 3.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 3.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.8 3.3 GO:0008142 oxysterol binding(GO:0008142)
0.2 3.1 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 2.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.4 2.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 2.4 GO:0008083 growth factor activity(GO:0008083)
0.3 2.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.6 1.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 1.6 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 1.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 1.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 7.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 5.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 2.0 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.4 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.1 0.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.6 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.3 PID_S1P_S1P2_PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.3 4.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 3.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.8 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.2 2.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.8 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.4 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 1.2 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 0.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.7 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.6 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules