Motif ID: Gmeb2

Z-value: 0.447


Transcription factors associated with Gmeb2:

Gene SymbolEntrez IDGene Name
Gmeb2 ENSMUSG00000038705.7 Gmeb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb2mm10_v2_chr2_-_181288016_1812880410.561.5e-02Click!


Activity profile for motif Gmeb2.

activity profile for motif Gmeb2


Sorted Z-values histogram for motif Gmeb2

Sorted Z-values for motif Gmeb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb2

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 0.764 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr7_-_119896285 0.616 ENSMUST00000106519.1
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr7_+_66839726 0.563 ENSMUST00000098382.3
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr11_-_107348130 0.532 ENSMUST00000134763.1
 Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr7_+_66839752 0.510 ENSMUST00000107478.1
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr17_-_85090204 0.484 ENSMUST00000072406.3
ENSMUST00000171795.1
 Prepl

prolyl endopeptidase-like

chr11_+_83302817 0.451 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr7_+_119896292 0.413 ENSMUST00000106517.1
 Lyrm1
LYR motif containing 1
chr4_-_147904643 0.397 ENSMUST00000150881.1
 Mfn2
mitofusin 2
chr17_-_94749874 0.357 ENSMUST00000171284.1
 Mettl4
methyltransferase like 4
chr11_+_83302641 0.349 ENSMUST00000176430.1
ENSMUST00000065692.7
 Ap2b1

adaptor-related protein complex 2, beta 1 subunit

chr2_+_168230597 0.349 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr4_+_101419696 0.348 ENSMUST00000131397.1
ENSMUST00000133055.1
 Ak4

adenylate kinase 4

chr3_+_131110350 0.345 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_-_119895697 0.325 ENSMUST00000059851.6
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr16_+_14361552 0.307 ENSMUST00000100167.3
ENSMUST00000154748.1
ENSMUST00000134776.1
 Abcc1


ATP-binding cassette, sub-family C (CFTR/MRP), member 1


chr14_+_32085804 0.305 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
 Oxnad1


oxidoreductase NAD-binding domain containing 1


chr4_+_139380658 0.300 ENSMUST00000165860.1
ENSMUST00000097822.3
 Ubr4

ubiquitin protein ligase E3 component n-recognin 4

chr19_-_40588374 0.297 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
 Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr9_+_46012822 0.292 ENSMUST00000120463.2
ENSMUST00000120247.1
 Sik3

SIK family kinase 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.2 GO:0010225 response to UV-C(GO:0010225)
0.1 0.8 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.6 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 0.5 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.1 0.5 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 0.5 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.5 GO:0046033 AMP metabolic process(GO:0046033)
0.0 0.5 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.1 0.4 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.3 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 0.3 GO:0042939 glutathione transport(GO:0034635) oligopeptide transmembrane transport(GO:0035672) xenobiotic transport(GO:0042908) tripeptide transport(GO:0042939)
0.1 0.3 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 0.3 GO:0018307 tRNA wobble position uridine thiolation(GO:0002143) enzyme active site formation(GO:0018307)
0.1 0.3 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.0 0.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.1 0.2 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 0.2 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 0.5 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.3 GO:0032280 symmetric synapse(GO:0032280)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.3 GO:0001741 XY body(GO:0001741)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0097413 Lewy body(GO:0097413)
0.0 0.2 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.9 GO:0030276 clathrin binding(GO:0030276)
0.3 0.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.6 GO:0005521 lamin binding(GO:0005521)
0.2 0.5 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.2 0.5 GO:0017084 glutamate 5-kinase activity(GO:0004349) glutamate-5-semialdehyde dehydrogenase activity(GO:0004350) delta1-pyrroline-5-carboxylate synthetase activity(GO:0017084) amino acid kinase activity(GO:0019202)
0.1 0.5 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 0.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.5 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.5 GO:0043394 proteoglycan binding(GO:0043394)
0.0 0.4 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673) sphingolipid transporter activity(GO:0046624)
0.1 0.3 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 0.3 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 0.3 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.3 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0000403 Y-form DNA binding(GO:0000403)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.3 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.5 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.2 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.2 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling