Motif ID: Smad1

Z-value: 1.091


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.428.6e-02Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 2.594 ENSMUST00000075312.3
 Ttr
transthyretin
chr7_-_110061319 1.421 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr2_+_164562579 1.324 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr7_+_66365905 1.143 ENSMUST00000107486.1
 Gm10974
predicted gene 10974
chrX_+_73483602 1.131 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr17_-_84682932 1.099 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr3_+_87948666 1.098 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr6_-_23248264 0.996 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_+_127211608 0.944 ENSMUST00000032910.6
 Mylpf
myosin light chain, phosphorylatable, fast skeletal muscle
chr7_-_25882407 0.896 ENSMUST00000163316.2
 Gm6434
predicted gene 6434
chr6_-_124911636 0.826 ENSMUST00000032217.1
 Lag3
lymphocyte-activation gene 3
chr7_-_4164442 0.813 ENSMUST00000140410.1
ENSMUST00000143825.1
 Cdc42ep5

CDC42 effector protein (Rho GTPase binding) 5

chr8_+_84872105 0.811 ENSMUST00000136026.1
ENSMUST00000170296.1
 Syce2

synaptonemal complex central element protein 2

chr7_+_17087934 0.809 ENSMUST00000152671.1
 Psg16
pregnancy specific glycoprotein 16
chr6_+_45060036 0.809 ENSMUST00000114641.1
 Cntnap2
contactin associated protein-like 2
chr9_+_119063429 0.791 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr1_-_138848576 0.784 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr8_+_31091593 0.784 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr12_+_109452833 0.764 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr4_-_55532453 0.756 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 635 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 3.0 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.5 2.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.3 1.8 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 1.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 1.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 1.7 GO:0046596 regulation of viral entry into host cell(GO:0046596)
0.0 1.4 GO:0006754 ATP biosynthetic process(GO:0006754)
0.4 1.3 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.3 1.3 GO:0072236 metanephric loop of Henle development(GO:0072236)
0.1 1.3 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 1.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 1.2 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.2 1.2 GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production(GO:0032725)
0.1 1.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 1.2 GO:0006413 translational initiation(GO:0006413)
0.4 1.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.4 1.1 GO:0030421 defecation(GO:0030421)
0.3 1.0 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.2 1.0 GO:1902340 telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 246 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 2.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.0 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.6 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.5 GO:0031012 extracellular matrix(GO:0031012)
0.2 1.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 1.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.4 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.4 GO:0000776 kinetochore(GO:0000776)
0.0 1.3 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 1.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 1.1 GO:0097346 INO80-type complex(GO:0097346)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 379 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 3.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 2.2 GO:0008201 heparin binding(GO:0008201)
0.3 2.1 GO:0019841 retinol binding(GO:0019841)
0.4 2.0 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 2.0 GO:0070888 E-box binding(GO:0070888)
0.0 2.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 1.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 1.3 GO:0031386 protein tag(GO:0031386)
0.1 1.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.3 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 1.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 1.2 GO:0019864 immunoglobulin receptor activity(GO:0019763) IgG binding(GO:0019864)
0.0 1.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 1.1 GO:0001848 complement binding(GO:0001848)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.1 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 3.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.1 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.9 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.8 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 5.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 3.9 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.0 3.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.1 2.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.5 REACTOME_TRANSLATION Genes involved in Translation
0.0 2.5 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.3 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
0.0 1.1 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 1.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.0 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.0 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation