Motif ID: Egr3

Z-value: 0.585


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.253.1e-01Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_110061319 4.378 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr17_+_87282880 0.648 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr7_+_144896523 0.612 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr17_-_87282771 0.514 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr8_+_62951361 0.514 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_87282793 0.501 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chrX_-_162159717 0.500 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr19_-_4615453 0.477 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr19_-_4615647 0.451 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr10_-_5922385 0.429 ENSMUST00000131996.1
ENSMUST00000064225.7
 Rgs17

regulator of G-protein signaling 17

chr10_-_5922341 0.428 ENSMUST00000117676.1
ENSMUST00000019909.7
 Rgs17

regulator of G-protein signaling 17

chr19_+_6975048 0.413 ENSMUST00000070850.6
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_86526688 0.405 ENSMUST00000045897.8
 Ptma
prothymosin alpha
chr13_-_85288999 0.405 ENSMUST00000109552.2
 Rasa1
RAS p21 protein activator 1
chr19_-_38224096 0.404 ENSMUST00000067167.5
 Fra10ac1
FRA10AC1 homolog (human)
chr8_+_85026833 0.398 ENSMUST00000047281.8
 2310036O22Rik
RIKEN cDNA 2310036O22 gene
chr11_+_98937669 0.390 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr13_-_41847626 0.365 ENSMUST00000121404.1
 Adtrp
androgen dependent TFPI regulating protein
chr2_+_75659253 0.348 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr11_-_69981242 0.348 ENSMUST00000108594.1
 Elp5
elongator acetyltransferase complex subunit 5
chr10_+_83722865 0.334 ENSMUST00000150459.1
 1500009L16Rik
RIKEN cDNA 1500009L16 gene
chr9_-_58204310 0.330 ENSMUST00000114144.2
 Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr7_-_119184374 0.323 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr5_-_149051604 0.318 ENSMUST00000093196.4
 Hmgb1
high mobility group box 1
chr4_-_41695935 0.315 ENSMUST00000145379.1
 Cntfr
ciliary neurotrophic factor receptor
chr2_+_85136355 0.311 ENSMUST00000057019.7
 Aplnr
apelin receptor
chr19_+_6400611 0.302 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr7_+_4740111 0.295 ENSMUST00000098853.2
 Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr7_+_4740178 0.291 ENSMUST00000108583.2
 Suv420h2
suppressor of variegation 4-20 homolog 2 (Drosophila)
chr1_-_156939387 0.275 ENSMUST00000171292.1
 Ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr4_-_40948196 0.267 ENSMUST00000030125.4
ENSMUST00000108089.1
 Bag1

BCL2-associated athanogene 1

chr13_-_41847482 0.265 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein
chr9_-_55048544 0.240 ENSMUST00000034854.6
 Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chrX_-_48513518 0.217 ENSMUST00000114945.2
ENSMUST00000037349.7
 Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

chr7_-_144939823 0.214 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_-_77489666 0.214 ENSMUST00000037593.7
ENSMUST00000092892.3
 Ankrd13b

ankyrin repeat domain 13b

chr16_-_94370994 0.209 ENSMUST00000113914.1
ENSMUST00000113905.1
 Pigp

phosphatidylinositol glycan anchor biosynthesis, class P

chr7_+_4740137 0.208 ENSMUST00000130215.1
ENSMUST00000108582.3
 Suv420h2

suppressor of variegation 4-20 homolog 2 (Drosophila)

chr13_-_107022027 0.203 ENSMUST00000117539.1
ENSMUST00000122233.1
ENSMUST00000022204.9
ENSMUST00000159772.1
 Kif2a



kinesin family member 2A



chr2_-_148045891 0.198 ENSMUST00000109964.1
 Foxa2
forkhead box A2
chr10_+_40883819 0.193 ENSMUST00000105509.1
 Wasf1
WAS protein family, member 1
chr3_-_95306794 0.193 ENSMUST00000107183.1
ENSMUST00000164406.1
ENSMUST00000123365.1
 Anxa9


annexin A9


chr7_+_3693602 0.191 ENSMUST00000123088.1
ENSMUST00000038521.7
ENSMUST00000108629.1
ENSMUST00000142713.1
 Tsen34



tRNA splicing endonuclease 34 homolog (S. cerevisiae)



chr18_-_41951187 0.186 ENSMUST00000070949.4
 Prelid2
PRELI domain containing 2
chrX_+_36195968 0.178 ENSMUST00000115256.1
 Zcchc12
zinc finger, CCHC domain containing 12
chr10_+_38965515 0.178 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr12_+_108635743 0.178 ENSMUST00000172409.1
 Evl
Ena-vasodilator stimulated phosphoprotein
chr3_+_135438722 0.176 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr11_+_71750680 0.174 ENSMUST00000021168.7
 Wscd1
WSC domain containing 1
chr3_-_119783262 0.169 ENSMUST00000029780.7
 Ptbp2
polypyrimidine tract binding protein 2
chr5_+_77265454 0.168 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr2_+_32395896 0.166 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr1_-_9299238 0.164 ENSMUST00000140295.1
 Sntg1
syntrophin, gamma 1
chr11_-_109722214 0.159 ENSMUST00000020938.7
 Fam20a
family with sequence similarity 20, member A
chrX_-_8252334 0.159 ENSMUST00000115595.1
ENSMUST00000033513.3
 Ftsj1

FtsJ homolog 1 (E. coli)

chr11_+_71750980 0.156 ENSMUST00000108511.1
 Wscd1
WSC domain containing 1
chr9_-_78481724 0.149 ENSMUST00000042235.8
 Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr9_+_106203108 0.148 ENSMUST00000024047.5
 Twf2
twinfilin, actin-binding protein, homolog 2 (Drosophila)
chr10_-_18023229 0.142 ENSMUST00000020002.7
 Abracl
ABRA C-terminal like
chrX_-_8252304 0.138 ENSMUST00000115594.1
 Ftsj1
FtsJ homolog 1 (E. coli)
chr4_+_40948401 0.135 ENSMUST00000030128.5
 Chmp5
charged multivesicular body protein 5
chr10_+_40883469 0.134 ENSMUST00000019975.7
 Wasf1
WAS protein family, member 1
chr17_-_79715034 0.134 ENSMUST00000024894.1
 Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
chr7_+_126759601 0.133 ENSMUST00000050201.4
ENSMUST00000057669.9
 Mapk3

mitogen-activated protein kinase 3

chr2_-_63184253 0.128 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr6_-_49214954 0.128 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr18_-_84086379 0.125 ENSMUST00000060303.8
 Tshz1
teashirt zinc finger family member 1
chr4_+_57637816 0.116 ENSMUST00000150412.1
 Gm20459
predicted gene 20459
chr11_-_119300070 0.115 ENSMUST00000026667.8
 Eif4a3
eukaryotic translation initiation factor 4A3
chr11_-_119300004 0.112 ENSMUST00000106253.1
 Eif4a3
eukaryotic translation initiation factor 4A3
chr18_-_12305638 0.105 ENSMUST00000122408.1
ENSMUST00000118525.1
ENSMUST00000142066.1
 Ankrd29


ankyrin repeat domain 29


chr1_+_74236479 0.105 ENSMUST00000113820.2
ENSMUST00000006467.7
ENSMUST00000113819.1
 Arpc2


actin related protein 2/3 complex, subunit 2


chr5_-_137072254 0.102 ENSMUST00000077523.3
ENSMUST00000041388.4
 Serpine1

serine (or cysteine) peptidase inhibitor, clade E, member 1

chr2_+_121413775 0.101 ENSMUST00000028683.7
 Pdia3
protein disulfide isomerase associated 3
chr11_-_98775333 0.099 ENSMUST00000064941.6
 Nr1d1
nuclear receptor subfamily 1, group D, member 1
chr2_-_173119402 0.099 ENSMUST00000094287.3
ENSMUST00000179693.1
 Ctcfl

CCCTC-binding factor (zinc finger protein)-like

chr1_+_120340569 0.096 ENSMUST00000037286.8
 C1ql2
complement component 1, q subcomponent-like 2
chr16_+_64851991 0.094 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr3_-_80802789 0.092 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr15_+_43477213 0.089 ENSMUST00000022962.6
 Emc2
ER membrane protein complex subunit 2
chr10_+_69533761 0.086 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr3_+_129213920 0.084 ENSMUST00000042587.10
 Pitx2
paired-like homeodomain transcription factor 2
chr19_+_16956110 0.078 ENSMUST00000087689.4
 Prune2
prune homolog 2 (Drosophila)
chr5_-_62765618 0.074 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr5_+_64970069 0.071 ENSMUST00000031080.8
 Fam114a1
family with sequence similarity 114, member A1
chr5_-_138279960 0.070 ENSMUST00000014089.7
ENSMUST00000161827.1
 Gpc2

glypican 2 (cerebroglycan)

chr18_+_65698253 0.068 ENSMUST00000115097.1
ENSMUST00000117694.1
 Oacyl

O-acyltransferase like

chr1_+_36068371 0.054 ENSMUST00000088174.3
 Hs6st1
heparan sulfate 6-O-sulfotransferase 1
chr3_-_138131356 0.043 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr2_+_3114220 0.034 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chrX_+_143664290 0.024 ENSMUST00000112868.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr5_+_129715488 0.023 ENSMUST00000119576.1
ENSMUST00000042191.5
ENSMUST00000118420.1
ENSMUST00000154358.1
ENSMUST00000121339.1
ENSMUST00000119604.1
ENSMUST00000136108.1
ENSMUST00000121813.1
ENSMUST00000119985.1
ENSMUST00000138812.1
 Mrps17









mitochondrial ribosomal protein S17









chr9_-_66124872 0.012 ENSMUST00000034946.8
 Snx1
sorting nexin 1
chr11_-_23895208 0.004 ENSMUST00000102863.2
ENSMUST00000020513.3
 Papolg

poly(A) polymerase gamma

chr19_-_6077183 0.004 ENSMUST00000025711.5
ENSMUST00000160590.1
 Vps51

vacuolar protein sorting 51 homolog (S. cerevisiae)

chr3_+_97901190 0.004 ENSMUST00000029476.2
ENSMUST00000122288.1
 Sec22b

SEC22 vesicle trafficking protein homolog B (S. cerevisiae)

chr2_+_116067213 0.002 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr5_+_138280538 0.001 ENSMUST00000162245.1
ENSMUST00000161691.1
 Stag3

stromal antigen 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 0.3 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.3 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.1 0.2 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 0.3 GO:0003360 brainstem development(GO:0003360)
0.1 0.2 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
0.1 0.2 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.3 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.3 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:0061763 multivesicular body-lysosome fusion(GO:0061763)
0.0 0.1 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:2000812 response to rapamycin(GO:1901355) regulation of barbed-end actin filament capping(GO:2000812)
0.0 0.1 GO:2000097 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:1903334 positive regulation of protein folding(GO:1903334)
0.0 0.1 GO:0010871 negative regulation of receptor biosynthetic process(GO:0010871)
0.0 0.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0032532 regulation of microvillus length(GO:0032532)
0.0 0.4 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 0.2 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.2 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.1 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.1 GO:0060578 extraocular skeletal muscle development(GO:0002074) subthalamic nucleus development(GO:0021763) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.0 0.4 GO:0043486 histone exchange(GO:0043486)
0.0 0.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0097228 sperm principal piece(GO:0097228)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.8 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.2 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.4 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.0 0.3 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.1 GO:0070330 aromatase activity(GO:0070330)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis