Motif ID: Egr3

Z-value: 0.585


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.253.1e-01Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 98 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_110061319 4.378 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr17_+_87282880 0.648 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr7_+_144896523 0.612 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr17_-_87282771 0.514 ENSMUST00000161759.1
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chr8_+_62951361 0.514 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr17_-_87282793 0.501 ENSMUST00000146560.2
 4833418N02Rik
RIKEN cDNA 4833418N02 gene
chrX_-_162159717 0.500 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr19_-_4615453 0.477 ENSMUST00000053597.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr19_-_4615647 0.451 ENSMUST00000113822.2
 Lrfn4
leucine rich repeat and fibronectin type III domain containing 4
chr10_-_5922385 0.429 ENSMUST00000131996.1
ENSMUST00000064225.7
 Rgs17

regulator of G-protein signaling 17

chr10_-_5922341 0.428 ENSMUST00000117676.1
ENSMUST00000019909.7
 Rgs17

regulator of G-protein signaling 17

chr19_+_6975048 0.413 ENSMUST00000070850.6
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_86526688 0.405 ENSMUST00000045897.8
 Ptma
prothymosin alpha
chr13_-_85288999 0.405 ENSMUST00000109552.2
 Rasa1
RAS p21 protein activator 1
chr19_-_38224096 0.404 ENSMUST00000067167.5
 Fra10ac1
FRA10AC1 homolog (human)
chr8_+_85026833 0.398 ENSMUST00000047281.8
 2310036O22Rik
RIKEN cDNA 2310036O22 gene
chr11_+_98937669 0.390 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr13_-_41847626 0.365 ENSMUST00000121404.1
 Adtrp
androgen dependent TFPI regulating protein
chr2_+_75659253 0.348 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr11_-_69981242 0.348 ENSMUST00000108594.1
 Elp5
elongator acetyltransferase complex subunit 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 0.6 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.6 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.4 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0 0.4 GO:0043486 histone exchange(GO:0043486)
0.1 0.3 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.3 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.1 0.3 GO:0003360 brainstem development(GO:0003360)
0.1 0.3 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.3 GO:1990416 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.2 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.1 0.2 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
0.1 0.2 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.0 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.2 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 0.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0015464 acetylcholine receptor activity(GO:0015464)
0.1 0.3 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.3 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.3 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.0 0.3 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 0.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.2 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.2 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.1 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.2 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols