Motif ID: Pax8

Z-value: 0.456


Transcription factors associated with Pax8:

Gene SymbolEntrez IDGene Name
Pax8 ENSMUSG00000026976.9 Pax8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax8mm10_v2_chr2_-_24475596_244756050.243.3e-01Click!


Activity profile for motif Pax8.

activity profile for motif Pax8


Sorted Z-values histogram for motif Pax8

Sorted Z-values for motif Pax8



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax8

PNG image of the network

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Top targets:


Showing 1 to 20 of 37 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_66860458 1.555 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr7_+_6961160 1.283 ENSMUST00000054055.6
 Usp29
ubiquitin specific peptidase 29
chr13_-_66852017 0.891 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr18_-_12121460 0.582 ENSMUST00000055447.6
ENSMUST00000050228.7
ENSMUST00000092075.4
 Tmem241


transmembrane protein 241


chr9_+_32116040 0.481 ENSMUST00000174641.1
 Arhgap32
Rho GTPase activating protein 32
chr4_+_103313806 0.465 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr7_+_112742025 0.435 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chr11_-_69801716 0.433 ENSMUST00000011285.4
ENSMUST00000102585.1
 Fgf11

fibroblast growth factor 11

chr9_-_103230415 0.417 ENSMUST00000035158.9
 Trf
transferrin
chr7_-_29906087 0.384 ENSMUST00000053521.8
 Zfp27
zinc finger protein 27
chr9_+_109052828 0.377 ENSMUST00000124432.1
 Shisa5
shisa homolog 5 (Xenopus laevis)
chr12_+_71048338 0.373 ENSMUST00000135709.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)
chr1_+_65186727 0.340 ENSMUST00000097707.4
ENSMUST00000081154.7
 Pikfyve

phosphoinositide kinase, FYVE finger containing

chr2_+_128967383 0.301 ENSMUST00000110320.2
ENSMUST00000110319.2
 Zc3h6

zinc finger CCCH type containing 6

chr11_+_78499087 0.252 ENSMUST00000017488.4
 Vtn
vitronectin
chr4_+_6191093 0.211 ENSMUST00000029907.5
 Ubxn2b
UBX domain protein 2B
chr17_+_45555693 0.201 ENSMUST00000024742.7
 Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
chr13_-_62777089 0.176 ENSMUST00000167516.2
 Gm5141
predicted gene 5141
chr13_-_25270076 0.160 ENSMUST00000057866.6
 Nrsn1
neurensin 1
chr8_-_64849818 0.160 ENSMUST00000034017.7
 Klhl2
kelch-like 2, Mayven

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.0 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 1.3 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.6 GO:0072530 purine-containing compound transmembrane transport(GO:0072530)
0.1 0.4 GO:0034773 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1 0.4 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.0 0.4 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.0 0.3 GO:0097421 liver regeneration(GO:0097421)
0.0 0.3 GO:0032288 myelin assembly(GO:0032288)
0.0 0.2 GO:0032329 serine transport(GO:0032329)
0.0 0.2 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.1 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)

Gene overrepresentation in cellular_component category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 0.4 GO:0097433 dense body(GO:0097433)
0.1 0.3 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular_function category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 1.3 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 0.6 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.4 GO:0050699 WW domain binding(GO:0050699)
0.0 0.3 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.3 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane