Motif ID: Gata3

Z-value: 0.854


Transcription factors associated with Gata3:

Gene SymbolEntrez IDGene Name
Gata3 ENSMUSG00000015619.10 Gata3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata3mm10_v2_chr2_-_9878580_9878607-0.233.7e-01Click!


Activity profile for motif Gata3.

activity profile for motif Gata3


Sorted Z-values histogram for motif Gata3

Sorted Z-values for motif Gata3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23890805 0.909 ENSMUST00000004480.3
 Sst
somatostatin
chrX_+_143518671 0.837 ENSMUST00000134402.1
 Pak3
p21 protein (Cdc42/Rac)-activated kinase 3
chr8_-_8639363 0.791 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr16_+_72663143 0.789 ENSMUST00000023600.7
 Robo1
roundabout homolog 1 (Drosophila)
chr10_+_81628702 0.745 ENSMUST00000129622.1
 Ankrd24
ankyrin repeat domain 24
chr7_-_30534180 0.740 ENSMUST00000044338.4
 Arhgap33
Rho GTPase activating protein 33
chr1_-_155417394 0.708 ENSMUST00000111775.1
ENSMUST00000111774.1
 Xpr1

xenotropic and polytropic retrovirus receptor 1

chr9_-_44234014 0.675 ENSMUST00000037644.6
 Cbl
Casitas B-lineage lymphoma
chr4_+_13751297 0.674 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_+_27299205 0.662 ENSMUST00000115247.1
ENSMUST00000133213.1
 Igsf9b

immunoglobulin superfamily, member 9B

chr11_-_100527862 0.660 ENSMUST00000107385.1
 Acly
ATP citrate lyase
chr17_+_85613432 0.650 ENSMUST00000176081.1
 Six3
sine oculis-related homeobox 3
chr19_-_59170978 0.648 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr1_+_66386968 0.644 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chrX_-_73966329 0.639 ENSMUST00000114372.2
ENSMUST00000033761.6
 Hcfc1

host cell factor C1

chr13_-_41273977 0.635 ENSMUST00000163881.1
 Gm17364
predicted gene, 17364
chr1_-_119053339 0.630 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chrX_-_145505175 0.599 ENSMUST00000143610.1
 Amot
angiomotin
chr7_-_103827922 0.594 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr8_-_106337987 0.589 ENSMUST00000067512.7
 Smpd3
sphingomyelin phosphodiesterase 3, neutral

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 251 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.1 1.7 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.3 1.4 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 1.4 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.3 1.3 GO:0015671 oxygen transport(GO:0015671)
0.0 1.2 GO:0061157 mRNA destabilization(GO:0061157)
0.3 1.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 1.0 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 0.9 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 0.9 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.9 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.1 0.9 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.3 0.8 GO:0070650 actin filament bundle distribution(GO:0070650)
0.3 0.8 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.8 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.2 0.7 GO:0097402 neuroblast migration(GO:0097402)
0.2 0.7 GO:1903294 axon target recognition(GO:0007412) regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
0.1 0.7 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 0.7 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0060076 excitatory synapse(GO:0060076)
0.2 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.0 1.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.3 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.2 GO:0045298 tubulin complex(GO:0045298)
0.1 1.2 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.1 1.1 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 1.0 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.9 GO:0031430 M band(GO:0031430)
0.1 0.8 GO:0097513 myosin II filament(GO:0097513)
0.1 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.7 GO:0008091 spectrin(GO:0008091)
0.1 0.7 GO:0016600 flotillin complex(GO:0016600)
0.0 0.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.7 GO:0043195 terminal bouton(GO:0043195)
0.1 0.6 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 0.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 1.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.6 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.5 GO:0099609 microtubule lateral binding(GO:0099609)
0.4 1.1 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.3 1.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.3 0.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.9 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.3 0.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.8 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.8 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.7 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.7 GO:0031402 sodium ion binding(GO:0031402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.9 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.4 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 1.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.3 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.3 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 0.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.2 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 1.1 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 1.0 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.9 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 0.8 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis