Motif ID: Hey1_Myc_Mxi1

Z-value: 0.931

Transcription factors associated with Hey1_Myc_Mxi1:

Gene SymbolEntrez IDGene Name
Hey1 ENSMUSG00000040289.3 Hey1
Mxi1 ENSMUSG00000025025.7 Mxi1
Myc ENSMUSG00000022346.8 Myc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey1mm10_v2_chr3_-_8667033_86670460.744.4e-04Click!
Mxi1mm10_v2_chr19_+_53329413_53329478-0.608.2e-03Click!
Mycmm10_v2_chr15_+_61987034_61987059-0.475.2e-02Click!


Activity profile for motif Hey1_Myc_Mxi1.

activity profile for motif Hey1_Myc_Mxi1


Sorted Z-values histogram for motif Hey1_Myc_Mxi1

Sorted Z-values for motif Hey1_Myc_Mxi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey1_Myc_Mxi1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_106458440 4.622 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr10_+_127063527 4.023 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chr5_-_137314175 3.766 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr10_+_127063599 3.743 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr14_-_20181773 3.537 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr6_+_7555053 3.207 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr9_-_43239816 3.192 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr19_+_56874249 2.921 ENSMUST00000026068.7
 Vwa2
von Willebrand factor A domain containing 2
chr9_-_114781986 2.896 ENSMUST00000035009.8
ENSMUST00000084867.7
 Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr2_+_121449362 2.888 ENSMUST00000110615.1
ENSMUST00000099475.5
 Serf2

small EDRK-rich factor 2

chr19_+_6975048 2.716 ENSMUST00000070850.6
 Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr10_-_30842765 2.520 ENSMUST00000019924.8
 Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr5_-_22344690 2.483 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr10_+_22158566 2.319 ENSMUST00000181645.1
ENSMUST00000105522.2
 Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr17_+_46496753 2.316 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr2_+_156840966 2.258 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr18_+_35553401 2.199 ENSMUST00000181664.1
 Snhg4
small nucleolar RNA host gene 4 (non-protein coding)
chr15_-_43170809 2.119 ENSMUST00000063492.6
 Rspo2
R-spondin 2 homolog (Xenopus laevis)
chr19_-_4201591 2.108 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chrX_-_155338460 2.056 ENSMUST00000026328.4
 Prdx4
peroxiredoxin 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 457 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.8 GO:0010288 response to lead ion(GO:0010288)
0.8 5.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.7 4.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 3.7 GO:1904591 positive regulation of protein import(GO:1904591)
0.3 3.6 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 3.6 GO:0001709 cell fate determination(GO:0001709)
0.1 3.6 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.3 3.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.3 3.3 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
1.1 3.2 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.8 3.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.6 3.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.5 3.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 3.1 GO:0016925 protein sumoylation(GO:0016925)
0.6 3.0 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
1.0 2.9 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.9 2.7 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.3 2.7 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.5 2.6 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.1 2.6 GO:0015804 neutral amino acid transport(GO:0015804)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 7.8 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 7.8 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 6.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 5.9 GO:0005925 focal adhesion(GO:0005925)
0.0 4.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 3.9 GO:0016580 Sin3 complex(GO:0016580)
0.1 3.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 3.8 GO:0005604 basement membrane(GO:0005604)
0.1 3.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 3.3 GO:0043196 varicosity(GO:0043196)
0.3 3.2 GO:0005642 annulate lamellae(GO:0005642)
0.4 3.1 GO:0031415 NatA complex(GO:0031415)
0.4 3.0 GO:0097422 tubular endosome(GO:0097422)
0.1 2.7 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.6 2.5 GO:0008537 proteasome activator complex(GO:0008537)
0.1 2.5 GO:0031527 filopodium membrane(GO:0031527)
0.2 2.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 2.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.6 2.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 2.3 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 301 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 8.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 6.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 5.6 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 4.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 4.7 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 4.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 4.3 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 3.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 3.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 3.7 GO:0051920 peroxiredoxin activity(GO:0051920)
0.2 3.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 3.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 3.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 3.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 3.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 3.2 GO:0003924 GTPase activity(GO:0003924)
0.6 3.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 3.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 2.8 GO:0016831 carboxy-lyase activity(GO:0016831)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.7 9.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 9.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.0 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 5.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 4.8 PID_INSULIN_PATHWAY Insulin Pathway
0.1 4.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 4.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.2 PID_BMP_PATHWAY BMP receptor signaling
0.1 4.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.1 PID_ATM_PATHWAY ATM pathway
0.1 1.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.5 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 11.8 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 9.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 6.3 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 6.2 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 6.2 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3 6.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 5.3 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 5.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.3 4.0 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 3.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 3.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 3.5 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 3.2 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 3.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.0 3.2 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.2 3.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 3.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 2.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis