Motif ID: Ctcfl_Ctcf

Z-value: 1.113

Transcription factors associated with Ctcfl_Ctcf:

Gene SymbolEntrez IDGene Name
Ctcf ENSMUSG00000005698.9 Ctcf
Ctcfl ENSMUSG00000070495.5 Ctcfl

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ctcfmm10_v2_chr8_+_105636509_1056365890.617.7e-03Click!
Ctcflmm10_v2_chr2_-_173119402_173119525-0.019.6e-01Click!


Activity profile for motif Ctcfl_Ctcf.

activity profile for motif Ctcfl_Ctcf


Sorted Z-values histogram for motif Ctcfl_Ctcf

Sorted Z-values for motif Ctcfl_Ctcf



Network of associatons between targets according to the STRING database.



First level regulatory network of Ctcfl_Ctcf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_34486125 3.562 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr11_+_103103051 3.327 ENSMUST00000152971.1
 Acbd4
acyl-Coenzyme A binding domain containing 4
chr18_-_43393346 3.165 ENSMUST00000025379.7
 Dpysl3
dihydropyrimidinase-like 3
chr11_+_84179792 3.070 ENSMUST00000137500.2
ENSMUST00000130012.2
 Acaca

acetyl-Coenzyme A carboxylase alpha

chr5_+_144768536 2.975 ENSMUST00000128550.1
 Trrap
transformation/transcription domain-associated protein
chr9_-_44234014 2.965 ENSMUST00000037644.6
 Cbl
Casitas B-lineage lymphoma
chr18_+_36952621 2.901 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr6_+_47835650 2.599 ENSMUST00000079881.4
ENSMUST00000114598.1
 Zfp398

zinc finger protein 398

chr9_-_98032983 2.546 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr11_-_76577701 2.529 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr2_+_65620829 2.526 ENSMUST00000028377.7
 Scn2a1
sodium channel, voltage-gated, type II, alpha 1
chr19_+_6418731 2.447 ENSMUST00000113462.1
ENSMUST00000077182.6
ENSMUST00000113461.1
 Nrxn2


neurexin II


chr1_+_191575721 2.351 ENSMUST00000045450.5
 Ints7
integrator complex subunit 7
chr3_-_89160155 2.273 ENSMUST00000029686.3
 Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr11_+_104231573 2.225 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr19_-_10304867 2.184 ENSMUST00000039327.4
 Dagla
diacylglycerol lipase, alpha
chr11_+_84179852 2.171 ENSMUST00000136463.2
 Acaca
acetyl-Coenzyme A carboxylase alpha
chr15_-_44788016 2.107 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr18_-_66291770 2.105 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr2_-_32353283 2.083 ENSMUST00000091089.5
ENSMUST00000113350.1
 Dnm1

dynamin 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.7 GO:0007416 synapse assembly(GO:0007416)
0.9 7.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.3 5.2 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
1.7 5.1 GO:0051542 elastin biosynthetic process(GO:0051542)
0.6 4.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 3.7 GO:0015711 organic anion transport(GO:0015711)
0.7 3.6 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 3.6 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.1 3.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
1.1 3.4 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.1 3.2 GO:0051764 actin crosslink formation(GO:0051764)
0.4 3.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.2 3.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.9 2.6 GO:0043181 vacuolar sequestering(GO:0043181)
0.5 2.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 2.5 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 2.5 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 2.4 GO:0042297 vocal learning(GO:0042297) imitative learning(GO:0098596)
0.3 2.3 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.7 2.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.2 GO:0070382 exocytic vesicle(GO:0070382)
0.8 7.9 GO:0045298 tubulin complex(GO:0045298)
0.0 7.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 7.0 GO:0000139 Golgi membrane(GO:0000139)
0.4 6.2 GO:0043196 varicosity(GO:0043196)
0.0 4.5 GO:0001650 fibrillar center(GO:0001650)
0.3 4.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 3.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 3.6 GO:0043198 dendritic shaft(GO:0043198)
0.1 3.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 3.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 3.0 GO:0016600 flotillin complex(GO:0016600)
0.1 2.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.4 GO:0032039 integrator complex(GO:0032039)
0.5 2.3 GO:0044316 cone cell pedicle(GO:0044316)
0.0 2.3 GO:0031901 early endosome membrane(GO:0031901)
0.2 2.2 GO:0000812 Swr1 complex(GO:0000812)
0.3 2.1 GO:0097433 dense body(GO:0097433)
0.2 2.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.9 GO:0099609 microtubule lateral binding(GO:0099609)
0.6 6.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 5.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
1.7 5.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 5.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.1 4.7 GO:0001540 beta-amyloid binding(GO:0001540)
1.0 4.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 4.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.9 3.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
1.1 3.2 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.4 3.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 3.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 3.1 GO:0005158 insulin receptor binding(GO:0005158)
0.2 3.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 2.8 GO:0030165 PDZ domain binding(GO:0030165)
0.3 2.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.9 2.6 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 2.5 GO:0015485 cholesterol binding(GO:0015485)
0.0 2.2 GO:0005246 calcium channel regulator activity(GO:0005246)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 6.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 4.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 3.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 3.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 3.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 3.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.2 PID_MYC_PATHWAY C-MYC pathway
0.1 1.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.3 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.0 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.7 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 5.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 5.2 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 5.0 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 4.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.4 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 4.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 3.7 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 3.6 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 3.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 2.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 2.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.1 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.9 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 1.8 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.7 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.6 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors