Motif ID: Rora

Z-value: 1.117


Transcription factors associated with Rora:

Gene SymbolEntrez IDGene Name
Rora ENSMUSG00000032238.11 Rora

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Roramm10_v2_chr9_+_68653761_686537860.701.2e-03Click!


Activity profile for motif Rora.

activity profile for motif Rora


Sorted Z-values histogram for motif Rora

Sorted Z-values for motif Rora



Network of associatons between targets according to the STRING database.



First level regulatory network of Rora

PNG image of the network

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Top targets:


Showing 1 to 20 of 195 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 8.979 ENSMUST00000168589.1
 Sla
src-like adaptor
chr1_+_159737510 3.526 ENSMUST00000111669.3
 Tnr
tenascin R
chr5_+_37028329 3.458 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr2_-_5676046 3.074 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr9_-_75597643 2.954 ENSMUST00000164100.1
 Tmod2
tropomodulin 2
chr11_+_42419729 2.923 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr7_-_79386943 2.842 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr16_+_11406618 2.772 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr2_+_4300462 2.669 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr5_-_113015473 2.630 ENSMUST00000065167.4
 Adrbk2
adrenergic receptor kinase, beta 2
chr2_+_170731807 2.418 ENSMUST00000029075.4
 Dok5
docking protein 5
chr5_-_106696819 2.408 ENSMUST00000127434.1
ENSMUST00000112696.1
ENSMUST00000112698.1
 Zfp644


zinc finger protein 644


chr7_-_12422751 2.398 ENSMUST00000080348.5
 Zfp551
zinc fingr protein 551
chr19_-_37207293 2.301 ENSMUST00000132580.1
ENSMUST00000079754.4
ENSMUST00000136286.1
ENSMUST00000126188.1
ENSMUST00000126781.1
 Cpeb3




cytoplasmic polyadenylation element binding protein 3




chr19_-_57314896 2.234 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr5_-_106696530 2.094 ENSMUST00000137285.1
ENSMUST00000124263.1
ENSMUST00000112695.1
ENSMUST00000155495.1
ENSMUST00000135108.1
 Zfp644




zinc finger protein 644




chr19_+_6400523 2.092 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr3_-_107517321 2.044 ENSMUST00000166892.1
 Slc6a17
solute carrier family 6 (neurotransmitter transporter), member 17
chr3_-_158562199 2.010 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr5_+_19227046 1.986 ENSMUST00000088516.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
1.4 4.2 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 3.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.9 3.5 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.6 3.2 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.4 3.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 3.1 GO:0050890 cognition(GO:0050890)
0.5 3.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 2.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 2.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 2.8 GO:0007601 visual perception(GO:0007601)
0.1 2.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 2.4 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0 2.1 GO:0050770 regulation of axonogenesis(GO:0050770)
0.4 2.0 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.2 2.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 2.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 1.9 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 1.9 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 1.9 GO:0031032 actomyosin structure organization(GO:0031032)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.9 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.9 GO:0008021 synaptic vesicle(GO:0008021)
0.2 4.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 3.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.2 3.5 GO:0072534 perineuronal net(GO:0072534)
0.0 3.0 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 2.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 2.1 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.0 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.0 GO:0043194 axon initial segment(GO:0043194)
0.2 1.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 1.8 GO:0032437 cuticular plate(GO:0032437)
0.2 1.5 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.4 GO:0046930 pore complex(GO:0046930)
0.1 1.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.4 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.7 4.2 GO:0019841 retinol binding(GO:0019841)
0.3 4.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 4.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.2 3.5 GO:0046625 sphingolipid binding(GO:0046625)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.3 3.0 GO:0005523 tropomyosin binding(GO:0005523)
0.7 2.9 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 2.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 2.8 GO:0050811 GABA receptor binding(GO:0050811)
0.1 2.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.5 GO:0030507 spectrin binding(GO:0030507)
0.0 2.5 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.2 GO:0005158 insulin receptor binding(GO:0005158)
0.2 2.1 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.3 2.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 2.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 2.0 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 3.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.6 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 2.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 2.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.2 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.8 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 1.4 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.0 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.7 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.3 PID_VEGFR1_PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 3.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 2.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 2.6 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 2.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.2 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.1 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.7 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 1.4 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 1.4 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.4 1.3 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 1.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.1 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation