Motif ID: Cbfb

Z-value: 0.520


Transcription factors associated with Cbfb:

Gene SymbolEntrez IDGene Name
Cbfb ENSMUSG00000031885.7 Cbfb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cbfbmm10_v2_chr8_+_105170668_105170686-0.106.9e-01Click!


Activity profile for motif Cbfb.

activity profile for motif Cbfb


Sorted Z-values histogram for motif Cbfb

Sorted Z-values for motif Cbfb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cbfb

PNG image of the network

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Top targets:


Showing 1 to 20 of 23 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 3.002 ENSMUST00000168589.1
 Sla
src-like adaptor
chr14_+_101729907 2.307 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr2_+_32721055 1.717 ENSMUST00000074248.4
 Sh2d3c
SH2 domain containing 3C
chr12_+_95692212 1.134 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr10_+_69925954 0.876 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
 Ank3


ankyrin 3, epithelial


chr4_-_6990774 0.763 ENSMUST00000039987.3
 Tox
thymocyte selection-associated high mobility group box
chr19_-_50678642 0.662 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr14_-_101729690 0.637 ENSMUST00000066461.3
 Gm9922
predicted gene 9922
chr2_+_164948219 0.471 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr8_+_90828820 0.464 ENSMUST00000109614.2
ENSMUST00000048665.6
 Chd9

chromodomain helicase DNA binding protein 9

chr19_-_50678485 0.377 ENSMUST00000111756.3
 Sorcs1
VPS10 domain receptor protein SORCS 1
chr17_-_64331817 0.348 ENSMUST00000172733.1
ENSMUST00000172818.1
 Pja2

praja 2, RING-H2 motif containing

chr1_+_151755339 0.277 ENSMUST00000059498.5
 Edem3
ER degradation enhancer, mannosidase alpha-like 3
chr11_-_74724670 0.243 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr5_+_24364804 0.241 ENSMUST00000030834.4
ENSMUST00000115090.1
 Nos3

nitric oxide synthase 3, endothelial cell

chr4_+_83417715 0.124 ENSMUST00000030206.3
ENSMUST00000071544.4
 Snapc3

small nuclear RNA activating complex, polypeptide 3

chr8_+_3353415 0.079 ENSMUST00000098966.3
 A430078G23Rik
RIKEN cDNA A430078G23 gene
chr2_+_72297895 0.070 ENSMUST00000144111.1
 Zak
sterile alpha motif and leucine zipper containing kinase AZK
chr6_+_136954521 0.052 ENSMUST00000137768.1
 Pde6h
phosphodiesterase 6H, cGMP-specific, cone, gamma
chr7_-_46795661 0.036 ENSMUST00000123725.1
 Hps5
Hermansky-Pudlak syndrome 5 homolog (human)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 1.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.5 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.3 GO:0036508 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.3 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.2 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0 0.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0009301 snRNA transcription(GO:0009301)

Gene overrepresentation in cellular_component category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.3 GO:0042805 actinin binding(GO:0042805)
0.2 1.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0045505 dynein intermediate chain binding(GO:0045505)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation