Motif ID: Myog_Tcf12

Z-value: 0.665

Transcription factors associated with Myog_Tcf12:

Gene SymbolEntrez IDGene Name
Myog ENSMUSG00000026459.4 Myog
Tcf12 ENSMUSG00000032228.10 Tcf12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf12mm10_v2_chr9_-_72111827_721118950.626.5e-03Click!


Activity profile for motif Myog_Tcf12.

activity profile for motif Myog_Tcf12


Sorted Z-values histogram for motif Myog_Tcf12

Sorted Z-values for motif Myog_Tcf12



Network of associatons between targets according to the STRING database.



First level regulatory network of Myog_Tcf12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 2.436 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr5_+_105415738 2.038 ENSMUST00000112707.1
 Lrrc8b
leucine rich repeat containing 8 family, member B
chr4_-_64046925 1.836 ENSMUST00000107377.3
 Tnc
tenascin C
chr4_+_48045144 1.483 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr6_+_54681687 1.410 ENSMUST00000046276.6
 2410066E13Rik
RIKEN cDNA 2410066E13 gene
chr13_+_83504032 1.338 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr15_-_66831625 1.294 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_+_16011851 1.255 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr4_+_119814495 1.230 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr3_+_146852359 1.153 ENSMUST00000038090.5
ENSMUST00000170055.1
 Ttll7

tubulin tyrosine ligase-like family, member 7

chr15_-_71727815 1.148 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr3_-_127225917 1.146 ENSMUST00000182064.1
ENSMUST00000182662.1
 Ank2

ankyrin 2, brain

chr11_-_6065538 1.146 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr3_-_127225847 1.142 ENSMUST00000182726.1
ENSMUST00000182779.1
 Ank2

ankyrin 2, brain

chr2_-_52335134 1.118 ENSMUST00000075301.3
 Neb
nebulin
chr5_+_37028329 1.108 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr6_-_148444336 1.094 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chrX_+_134404780 1.035 ENSMUST00000113224.2
ENSMUST00000113226.1
 Drp2

dystrophin related protein 2

chr15_-_66812593 1.029 ENSMUST00000100572.3
 Sla
src-like adaptor
chrX_+_134404543 1.022 ENSMUST00000113228.1
ENSMUST00000153424.1
 Drp2

dystrophin related protein 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 280 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.7 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 4.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 2.5 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.5 1.8 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.4 1.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 1.7 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 1.7 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 1.7 GO:0050821 protein stabilization(GO:0050821)
0.3 1.6 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 1.6 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 1.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 1.5 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.2 1.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 1.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.4 1.3 GO:0007521 muscle cell fate determination(GO:0007521) positive regulation of macrophage apoptotic process(GO:2000111)
0.4 1.2 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 1.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.1 1.2 GO:0015693 magnesium ion transport(GO:0015693)
0.4 1.1 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.2 1.1 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0097060 synaptic membrane(GO:0097060)
0.2 5.1 GO:0031430 M band(GO:0031430)
0.0 3.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.2 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.1 GO:0060077 inhibitory synapse(GO:0060077)
0.1 1.8 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.6 GO:0043198 dendritic shaft(GO:0043198)
0.5 1.5 GO:0043512 inhibin A complex(GO:0043512)
0.0 1.3 GO:0034702 ion channel complex(GO:0034702)
0.1 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 1.1 GO:0031672 A band(GO:0031672)
0.0 1.1 GO:0051233 spindle midzone(GO:0051233)
0.2 1.0 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.9 GO:0090544 BAF-type complex(GO:0090544)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0030507 spectrin binding(GO:0030507)
0.0 4.6 GO:0003779 actin binding(GO:0003779)
0.1 3.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 2.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.0 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 1.8 GO:0045545 syndecan binding(GO:0045545)
0.0 1.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 1.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.3 GO:0003680 AT DNA binding(GO:0003680)
0.0 1.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.3 1.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.3 1.2 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 1.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.2 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.1 1.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.1 2.7 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 1.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.1 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.0 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.0 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 0.7 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.7 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.6 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.6 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 0.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 2.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.6 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.4 1.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.5 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.0 1.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.1 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.0 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.8 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 0.7 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.7 REACTOME_ION_CHANNEL_TRANSPORT Genes involved in Ion channel transport