Motif ID: Foxf2

Z-value: 0.812


Transcription factors associated with Foxf2:

Gene SymbolEntrez IDGene Name
Foxf2 ENSMUSG00000038402.2 Foxf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxf2mm10_v2_chr13_+_31625802_316258160.029.5e-01Click!


Activity profile for motif Foxf2.

activity profile for motif Foxf2


Sorted Z-values histogram for motif Foxf2

Sorted Z-values for motif Foxf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 97 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 3.281 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr16_+_91269759 2.876 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr6_-_148444336 2.209 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr16_-_22439570 1.671 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr8_-_84773381 1.548 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr10_+_60106452 1.540 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr16_-_34263179 1.496 ENSMUST00000114949.1
ENSMUST00000114954.1
 Kalrn

kalirin, RhoGEF kinase

chr7_+_30291941 1.351 ENSMUST00000144508.1
 Clip3
CAP-GLY domain containing linker protein 3
chr1_+_179546303 1.325 ENSMUST00000040706.8
 Cnst
consortin, connexin sorting protein
chr7_+_82175156 1.228 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chr4_+_101507947 1.191 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr7_+_30291659 1.101 ENSMUST00000014065.8
ENSMUST00000150892.1
ENSMUST00000126216.1
 Clip3


CAP-GLY domain containing linker protein 3


chr7_-_4844665 1.005 ENSMUST00000066041.5
ENSMUST00000172377.1
 Shisa7

shisa homolog 7 (Xenopus laevis)

chr2_+_28641227 0.992 ENSMUST00000028155.5
ENSMUST00000113869.1
ENSMUST00000113867.2
 Tsc1


tuberous sclerosis 1


chr17_+_70522083 0.981 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr4_+_101507855 0.948 ENSMUST00000038207.5
 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr2_+_112265809 0.920 ENSMUST00000110991.2
 Slc12a6
solute carrier family 12, member 6
chr16_-_34262945 0.909 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr16_-_22439719 0.841 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr10_+_40349265 0.789 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.3 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.6 3.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.4 2.5 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.3 2.4 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 2.3 GO:0048663 neuron fate commitment(GO:0048663)
0.4 2.1 GO:0072318 clathrin coat disassembly(GO:0072318)
0.1 1.8 GO:0070842 aggresome assembly(GO:0070842)
0.2 1.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 1.4 GO:0035826 rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)
0.4 1.3 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 1.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.3 1.0 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.1 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.8 GO:0008209 androgen metabolic process(GO:0008209)
0.0 0.8 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.7 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.7 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0014069 postsynaptic density(GO:0014069)
0.2 5.7 GO:0055038 recycling endosome membrane(GO:0055038)
0.3 1.0 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 1.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 0.8 GO:0031673 H zone(GO:0031673)
0.1 0.7 GO:1990130 Iml1 complex(GO:1990130)
0.2 0.6 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.6 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 0.5 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.3 GO:0044753 amphisome(GO:0044753)
0.0 0.1 GO:0032300 mismatch repair complex(GO:0032300)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.4 2.5 GO:0097001 ceramide binding(GO:0097001)
0.1 2.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 1.3 GO:0071253 connexin binding(GO:0071253)
0.0 1.0 GO:0032794 GTPase activating protein binding(GO:0032794)
0.2 0.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.7 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 0.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.6 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.6 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.1 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 0.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.0 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.7 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.5 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.4 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.3 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1