Motif ID: Gli3_Zic1

Z-value: 1.707

Transcription factors associated with Gli3_Zic1:

Gene SymbolEntrez IDGene Name
Gli3 ENSMUSG00000021318.9 Gli3
Zic1 ENSMUSG00000032368.8 Zic1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli3mm10_v2_chr13_+_15463837_15463980-0.744.6e-04Click!
Zic1mm10_v2_chr9_-_91365778_91365815-0.561.6e-02Click!


Activity profile for motif Gli3_Zic1.

activity profile for motif Gli3_Zic1


Sorted Z-values histogram for motif Gli3_Zic1

Sorted Z-values for motif Gli3_Zic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli3_Zic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 6.682 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr6_-_101377897 5.932 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr2_-_36104060 5.519 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr9_+_50752758 4.382 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr8_+_70501116 3.771 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr1_-_133801031 3.537 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr4_+_48045144 3.399 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr4_+_124657646 3.281 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr2_-_29253001 3.247 ENSMUST00000071201.4
 Ntng2
netrin G2
chr7_+_99268338 3.201 ENSMUST00000107100.2
 Map6
microtubule-associated protein 6
chr8_-_105966038 3.161 ENSMUST00000116429.2
ENSMUST00000034370.9
 Slc12a4

solute carrier family 12, member 4

chr8_+_76902277 3.041 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
 Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr17_-_24209377 2.978 ENSMUST00000024931.4
 Ntn3
netrin 3
chr3_+_68494208 2.841 ENSMUST00000182719.1
 Schip1
schwannomin interacting protein 1
chr11_-_42000284 2.819 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr11_-_116654245 2.809 ENSMUST00000021166.5
 Cygb
cytoglobin
chr1_-_56972437 2.804 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr4_-_148130678 2.796 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr1_-_69108039 2.695 ENSMUST00000121473.1
 Erbb4
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
chr13_-_117025505 2.663 ENSMUST00000022239.6
 Parp8
poly (ADP-ribose) polymerase family, member 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.7 GO:0071420 cellular response to histamine(GO:0071420)
0.1 7.3 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 6.7 GO:0048663 neuron fate commitment(GO:0048663)
0.3 5.6 GO:0001553 luteinization(GO:0001553)
0.9 5.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.6 5.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
1.6 4.8 GO:1904978 regulation of endosome organization(GO:1904978) positive regulation of endosome organization(GO:1904980)
0.1 4.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.7 4.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 4.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.4 4.3 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0 4.1 GO:0006813 potassium ion transport(GO:0006813)
0.1 3.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.6 3.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
1.2 3.6 GO:0032242 regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.1 3.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 3.3 GO:0032418 lysosome localization(GO:0032418)
1.1 3.2 GO:2000331 regulation of terminal button organization(GO:2000331)
0.5 3.2 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.4 3.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 7.6 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.1 6.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 6.4 GO:0016604 nuclear body(GO:0016604)
0.3 5.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 5.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 5.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 4.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 4.4 GO:0032279 asymmetric synapse(GO:0032279)
0.4 4.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 4.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 4.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 3.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
1.3 3.8 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.6 3.7 GO:0097512 cardiac myofibril(GO:0097512)
0.0 3.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 3.5 GO:0097228 sperm principal piece(GO:0097228)
0.0 3.3 GO:0005925 focal adhesion(GO:0005925)
0.6 3.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 3.2 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.8 GO:0008017 microtubule binding(GO:0008017)
0.4 5.3 GO:0004890 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
1.0 4.8 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0 4.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 4.4 GO:0030507 spectrin binding(GO:0030507)
0.5 4.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
1.0 4.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.2 4.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.3 4.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.5 3.8 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.2 3.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 3.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 3.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.5 3.6 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.6 3.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 3.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 3.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.5 3.2 GO:1990430 G-protein coupled GABA receptor activity(GO:0004965) extracellular matrix protein binding(GO:1990430)
0.5 3.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 3.2 GO:0042043 neurexin family protein binding(GO:0042043)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 6.1 PID_ARF6_PATHWAY Arf6 signaling events
0.3 4.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 3.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 3.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 3.3 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.9 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 2.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 2.0 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.1 1.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.7 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 1.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.4 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 7.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 6.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 4.3 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.3 4.0 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 3.6 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.1 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 2.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.7 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 2.6 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 2.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 2.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.3 2.0 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 1.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.4 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation