Motif ID: Tbx4

Z-value: 1.314


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_164562579 9.880 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr10_+_26229707 8.271 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr14_-_70642268 8.207 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr10_-_120899067 5.755 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr17_+_29093763 5.617 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr1_-_138847579 5.383 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr9_-_43239816 4.949 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr1_+_6730051 3.949 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr4_-_134018829 3.732 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr6_-_94700137 3.334 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr11_-_94507337 3.327 ENSMUST00000040692.8
 Mycbpap
MYCBP associated protein
chr7_-_28302238 3.234 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr6_+_7555053 2.872 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr12_+_3891728 2.586 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr2_-_148045891 2.214 ENSMUST00000109964.1
 Foxa2
forkhead box A2
chrX_-_53269020 2.173 ENSMUST00000114838.1
 Fam122b
family with sequence similarity 122, member B
chr4_+_11191726 2.081 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr2_-_57114970 2.071 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr2_-_148046896 2.049 ENSMUST00000172928.1
ENSMUST00000047315.3
 Foxa2

forkhead box A2

chr2_-_13011747 1.949 ENSMUST00000061545.5
 C1ql3
C1q-like 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 8.2 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
1.4 5.8 GO:0030091 protein repair(GO:0030091)
0.6 5.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.5 5.6 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
1.1 5.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 5.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.4 4.3 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.4 3.7 GO:0010587 miRNA catabolic process(GO:0010587)
0.3 3.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
1.1 3.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.6 3.2 GO:0007386 compartment pattern specification(GO:0007386)
1.0 2.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 2.9 GO:0007129 synapsis(GO:0007129)
0.3 2.6 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.7 2.1 GO:0051866 general adaptation syndrome(GO:0051866)
0.2 2.1 GO:0090527 actin filament reorganization(GO:0090527)
0.7 2.0 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 1.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.9 GO:0042149 cellular response to glucose starvation(GO:0042149)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 5.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
1.0 3.0 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 3.0 GO:0005581 collagen trimer(GO:0005581)
0.1 2.6 GO:0001741 XY body(GO:0001741)
0.0 2.1 GO:0005884 actin filament(GO:0005884)
0.3 1.9 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 1.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.0 GO:0005787 signal peptidase complex(GO:0005787)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 9.9 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
2.7 8.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
1.0 5.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
1.9 5.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 5.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 5.4 GO:0001047 core promoter binding(GO:0001047)
0.1 4.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 3.7 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 3.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 3.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 3.2 GO:0005112 Notch binding(GO:0005112)
0.3 2.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 2.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 2.0 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 1.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 1.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 PID_FGF_PATHWAY FGF signaling pathway
0.6 5.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 4.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 3.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 3.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 2.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.6 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 5.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 5.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.3 4.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 2.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 2.0 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.3 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 1.0 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.0 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.8 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.3 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport