Motif ID: Pitx2_Otx2

Z-value: 2.205

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx2mm10_v2_chr14_-_48665098_486652460.753.3e-04Click!
Pitx2mm10_v2_chr3_+_129213920_1292139380.361.4e-01Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_164562579 11.436 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr7_-_75782080 8.142 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr6_+_34354119 6.961 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr6_-_88898664 6.841 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr11_-_106998483 6.677 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr17_+_35861318 6.477 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr9_+_119357381 6.127 ENSMUST00000039610.8
 Xylb
xylulokinase homolog (H. influenzae)
chr7_+_16781341 5.846 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_+_87635974 5.642 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr14_-_20181773 5.570 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr1_-_175979114 5.541 ENSMUST00000104983.1
 B020018G12Rik
RIKEN cDNA B020018G12 gene
chr1_+_135232045 5.203 ENSMUST00000110798.3
 Gm4204
predicted gene 4204
chr9_-_100486788 5.005 ENSMUST00000098458.3
 Il20rb
interleukin 20 receptor beta
chr7_-_34812677 4.913 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr11_-_60811228 4.788 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr6_+_56017489 4.729 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr3_+_85915722 4.719 ENSMUST00000054148.7
 Gm9790
predicted gene 9790
chr11_+_97029925 4.692 ENSMUST00000021249.4
 Scrn2
secernin 2
chr10_-_128180265 4.641 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr8_+_33653238 4.603 ENSMUST00000033992.8
 Gsr
glutathione reductase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 417 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.4 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.5 12.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 10.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 10.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.1 8.5 GO:0022904 respiratory electron transport chain(GO:0022904)
2.6 7.9 GO:0042732 D-xylose metabolic process(GO:0042732)
2.4 7.3 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.3 7.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
2.3 7.0 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.7 6.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 6.7 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.5 6.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 6.0 GO:0006749 glutathione metabolic process(GO:0006749)
1.4 5.6 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.6 5.6 GO:0030322 stabilization of membrane potential(GO:0030322)
1.4 5.5 GO:0015825 L-serine transport(GO:0015825)
0.1 5.5 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 5.5 GO:0010921 regulation of phosphatase activity(GO:0010921)
0.2 5.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 5.2 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 37.3 GO:0070062 extracellular exosome(GO:0070062)
0.4 28.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 17.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 13.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 13.2 GO:0005643 nuclear pore(GO:0005643)
0.7 11.1 GO:0005652 nuclear lamina(GO:0005652)
0.2 10.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 10.8 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
1.1 8.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 8.4 GO:0016607 nuclear speck(GO:0016607)
0.8 8.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 7.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 6.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 6.2 GO:0005581 collagen trimer(GO:0005581)
0.4 6.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.8 5.9 GO:0001940 male pronucleus(GO:0001940)
0.4 5.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 5.2 GO:0031527 filopodium membrane(GO:0031527)
0.8 4.7 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.1 4.7 GO:0005913 cell-cell adherens junction(GO:0005913)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 294 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 45.2 GO:0003735 structural constituent of ribosome(GO:0003735)
2.3 11.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.4 11.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 8.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 8.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.6 8.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 8.0 GO:0005198 structural molecule activity(GO:0005198)
2.4 7.3 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.3 7.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.4 7.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.5 6.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 6.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.4 6.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4 6.3 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.2 6.2 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 6.2 GO:0045296 cadherin binding(GO:0045296)
2.0 6.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 5.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 5.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 5.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 13.1 PID_ATR_PATHWAY ATR signaling pathway
0.4 12.0 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 10.4 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 9.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 6.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 5.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 4.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 3.9 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.1 3.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 3.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 3.3 PID_E2F_PATHWAY E2F transcription factor network
0.1 2.9 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 2.6 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 2.6 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.1 2.4 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 2.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 40.2 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.4 26.8 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2 15.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 13.6 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.5 8.5 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.4 8.1 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.4 8.0 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 7.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 7.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 6.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 6.1 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 6.1 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 5.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 5.5 REACTOME_MRNA_CAPPING Genes involved in mRNA Capping
0.2 5.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 5.0 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 4.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.2 4.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 4.4 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.3 4.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition