Motif ID: Cux1

Z-value: 0.768


Transcription factors associated with Cux1:

Gene SymbolEntrez IDGene Name
Cux1 ENSMUSG00000029705.11 Cux1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux1mm10_v2_chr5_-_136565432_1365655300.513.2e-02Click!


Activity profile for motif Cux1.

activity profile for motif Cux1


Sorted Z-values histogram for motif Cux1

Sorted Z-values for motif Cux1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cux1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_96210107 1.614 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr5_+_117841839 1.606 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr2_+_71528657 1.432 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr7_-_103827922 1.252 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr2_+_71529085 1.207 ENSMUST00000152711.1
 Dlx1
distal-less homeobox 1
chr5_+_66968961 1.124 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr5_-_122050102 1.114 ENSMUST00000154139.1
 Cux2
cut-like homeobox 2
chr17_-_6449571 1.100 ENSMUST00000180035.1
 Tmem181b-ps
transmembrane protein 181B, pseudogene
chr5_+_66968559 1.072 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chrX_-_94212638 1.009 ENSMUST00000113922.1
 Eif2s3x
eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
chr8_+_12385769 0.985 ENSMUST00000080795.8
 Gm5607
predicted gene 5607
chr4_+_119814495 0.936 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr16_-_4003750 0.936 ENSMUST00000171658.1
ENSMUST00000171762.1
 Slx4

SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

chr14_+_121035194 0.879 ENSMUST00000135010.1
 Farp1
FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)
chr1_+_66386968 0.877 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr5_-_145201829 0.875 ENSMUST00000162220.1
ENSMUST00000031632.8
 Zkscan14

zinc finger with KRAB and SCAN domains 14

chr7_+_25268387 0.804 ENSMUST00000169392.1
 Cic
capicua homolog (Drosophila)
chr7_-_74013676 0.767 ENSMUST00000026896.4
 St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr7_-_19166119 0.760 ENSMUST00000094790.3
 Gipr
gastric inhibitory polypeptide receptor
chr15_-_67113909 0.753 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 136 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 2.1 GO:0031032 actomyosin structure organization(GO:0031032)
0.5 1.6 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.4 1.6 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.4 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.3 1.1 GO:0014042 positive regulation of neuron maturation(GO:0014042)
0.2 1.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 1.1 GO:0007614 short-term memory(GO:0007614)
0.0 1.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 0.9 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.1 0.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.8 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.0 0.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.7 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1 0.7 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.1 0.7 GO:0001927 exocyst assembly(GO:0001927)
0.1 0.7 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 0.7 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.3 1.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 1.0 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.2 0.9 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.9 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.8 GO:0030673 axolemma(GO:0030673)
0.1 0.7 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.7 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.7 GO:0000145 exocyst(GO:0000145)
0.0 0.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 0.5 GO:1903095 microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.5 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 0.4 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.4 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.4 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.5 1.6 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 1.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.3 1.3 GO:0031720 haptoglobin binding(GO:0031720)
0.0 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 1.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 0.9 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.9 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 0.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 0.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.8 GO:0030276 clathrin binding(GO:0030276)
0.2 0.7 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.6 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 1.1 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.4 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.3 PID_AR_NONGENOMIC_PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.2 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.1 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.7 REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 0.6 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME_SIGNALING_BY_NOTCH2 Genes involved in Signaling by NOTCH2
0.0 0.4 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation