Motif ID: Nr5a2

Z-value: 0.450


Transcription factors associated with Nr5a2:

Gene SymbolEntrez IDGene Name
Nr5a2 ENSMUSG00000026398.8 Nr5a2



Activity profile for motif Nr5a2.

activity profile for motif Nr5a2


Sorted Z-values histogram for motif Nr5a2

Sorted Z-values for motif Nr5a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr5a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_21722057 1.015 ENSMUST00000110476.3
Hist1h2bm
histone cluster 1, H2bm
chr17_+_43952999 0.972 ENSMUST00000177857.1
Rcan2
regulator of calcineurin 2
chr9_-_119578981 0.948 ENSMUST00000117911.1
ENSMUST00000120420.1
Scn5a

sodium channel, voltage-gated, type V, alpha

chr11_-_4704334 0.774 ENSMUST00000058407.5
Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr7_-_4522427 0.625 ENSMUST00000098859.3
Tnni3
troponin I, cardiac 3
chr10_+_94198955 0.584 ENSMUST00000020209.9
ENSMUST00000179990.1
Ndufa12

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12

chr2_-_73911323 0.584 ENSMUST00000111996.1
ENSMUST00000018914.2
Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr10_+_80805233 0.572 ENSMUST00000036016.4
Amh
anti-Mullerian hormone
chr14_+_122181694 0.564 ENSMUST00000026625.5
Clybl
citrate lyase beta like
chr12_-_110978981 0.549 ENSMUST00000135131.1
ENSMUST00000043459.6
ENSMUST00000128353.1
Ankrd9


ankyrin repeat domain 9


chr16_+_32608920 0.505 ENSMUST00000023486.8
Tfrc
transferrin receptor
chr18_+_6332587 0.490 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr8_+_120668308 0.472 ENSMUST00000181795.1
Cox4i1
cytochrome c oxidase subunit IV isoform 1
chr9_-_96437434 0.465 ENSMUST00000070500.2
BC043934
cDNA sequence BC043934
chr1_+_36691487 0.456 ENSMUST00000081180.4
Cox5b
cytochrome c oxidase subunit Vb
chr7_-_116237767 0.448 ENSMUST00000182834.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr7_-_81706905 0.447 ENSMUST00000026922.7
Homer2
homer homolog 2 (Drosophila)
chr8_-_70523085 0.443 ENSMUST00000137610.1
ENSMUST00000121623.1
ENSMUST00000093456.5
ENSMUST00000118850.1
Kxd1



KxDL motif containing 1



chr7_-_4522794 0.439 ENSMUST00000140424.1
Tnni3
troponin I, cardiac 3
chr16_-_91931643 0.432 ENSMUST00000023677.3
Atp5o
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0006334 nucleosome assembly(GO:0006334)
0.3 1.6 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 1.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 1.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.2 GO:0006342 chromatin silencing(GO:0006342)
0.2 1.1 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 1.1 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 1.1 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.0 GO:0007614 short-term memory(GO:0007614)
0.3 0.9 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
0.1 0.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.8 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536) negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 0.7 GO:0072615 interleukin-17 secretion(GO:0072615)
0.0 0.6 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.2 0.5 GO:0046133 pyrimidine ribonucleoside catabolic process(GO:0046133)
0.2 0.5 GO:0048162 preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.1 0.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.5 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244)
0.0 0.5 GO:0006228 UTP biosynthetic process(GO:0006228)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.0 1.7 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.2 1.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 1.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 1.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 0.7 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.1 0.6 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.4 GO:0032426 stereocilium tip(GO:0032426)
0.0 0.4 GO:0005687 U4 snRNP(GO:0005687)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 0.3 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 1.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 1.1 GO:0030172 troponin C binding(GO:0030172)
0.0 1.1 GO:0009055 electron carrier activity(GO:0009055)
0.2 1.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 1.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.2 0.7 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.7 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.7 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 0.6 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.1 0.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.6 GO:0015266 protein channel activity(GO:0015266)
0.0 0.6 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.6 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 0.5 GO:0016018 cyclosporin A binding(GO:0016018)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 0.6 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.9 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 1.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.7 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.5 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 0.5 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.2 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.1 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK