Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 2.221

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2mm10_v2_chr2_-_73892530_738925550.932.1e-08Click!
Ezh2mm10_v2_chr6_-_47594967_47595047-0.711.1e-03Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 14.685 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr2_+_4300462 12.311 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr9_+_27790947 10.443 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr14_-_79771305 10.122 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr1_-_154725920 9.646 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr8_+_57455898 9.476 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr16_+_45094036 8.856 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr16_+_45093611 8.293 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr9_-_117252450 7.820 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chr19_-_28911879 7.555 ENSMUST00000179171.1
 AC163993.1
AC163993.1
chr19_+_26623419 6.904 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_67748212 6.596 ENSMUST00000180887.1
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr13_+_42709482 6.524 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr2_-_66410064 6.402 ENSMUST00000112366.1
 Scn1a
sodium channel, voltage-gated, type I, alpha
chr1_-_56969827 6.052 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_-_82505707 5.552 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr12_-_78980758 5.542 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr2_+_65845833 5.522 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr1_+_66175272 5.488 ENSMUST00000156636.2
 Map2
microtubule-associated protein 2
chr1_-_169747634 5.250 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 415 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 20.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 16.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 14.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.4 14.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
1.3 14.2 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.3 14.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.3 12.3 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 11.4 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 11.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 10.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.7 10.4 GO:0071872 response to epinephrine(GO:0071871) cellular response to epinephrine stimulus(GO:0071872)
2.4 9.5 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.0 9.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 8.2 GO:0035641 locomotory exploration behavior(GO:0035641)
0.9 7.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.7 7.4 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 7.2 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.1 6.8 GO:0007416 synapse assembly(GO:0007416)
1.3 6.7 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.3 6.6 GO:0090036 regulation of protein kinase C signaling(GO:0090036)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 30.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.5 22.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.2 19.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 15.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 14.5 GO:0005887 integral component of plasma membrane(GO:0005887)
1.5 13.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 13.1 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 12.9 GO:0031225 anchored component of membrane(GO:0031225)
0.7 12.7 GO:0032279 asymmetric synapse(GO:0032279)
0.5 11.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.6 11.1 GO:0016514 SWI/SNF complex(GO:0016514)
0.1 9.9 GO:0030315 T-tubule(GO:0030315)
0.1 9.1 GO:0030027 lamellipodium(GO:0030027)
0.0 9.0 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.2 8.1 GO:0034707 chloride channel complex(GO:0034707)
0.5 8.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.9 7.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 7.9 GO:0043204 perikaryon(GO:0043204)
0.0 7.2 GO:0000139 Golgi membrane(GO:0000139)
0.3 5.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 266 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.9 GO:0005509 calcium ion binding(GO:0005509)
0.6 17.7 GO:0001968 fibronectin binding(GO:0001968)
3.7 14.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.7 13.7 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 13.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.9 12.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 12.7 GO:0030674 protein binding, bridging(GO:0030674)
1.8 12.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.3 10.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 10.3 GO:0017124 SH3 domain binding(GO:0017124)
0.4 8.0 GO:0031402 sodium ion binding(GO:0031402)
0.7 7.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 7.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 7.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.5 7.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.6 6.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.8 6.4 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 6.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 5.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.8 5.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.4 PID_LKB1_PATHWAY LKB1 signaling events
0.2 9.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 9.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 5.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 5.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 4.4 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 4.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.3 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.8 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.8 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.0 PID_IGF1_PATHWAY IGF1 pathway
0.3 2.9 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 2.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.5 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 2.5 PID_INSULIN_PATHWAY Insulin Pathway
0.1 2.3 PID_EPHB_FWD_PATHWAY EPHB forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 15.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
1.8 14.7 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 9.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 8.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 7.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.4 6.8 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 6.7 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.6 6.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 5.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 5.7 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 5.3 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 5.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 4.8 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 4.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 4.5 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 4.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.9 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.2 3.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 3.7 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.7 3.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones