Motif ID: Sox2

Z-value: 1.802


Transcription factors associated with Sox2:

Gene SymbolEntrez IDGene Name
Sox2 ENSMUSG00000074637.4 Sox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox2mm10_v2_chr3_+_34649987_34650005-0.019.8e-01Click!


Activity profile for motif Sox2.

activity profile for motif Sox2


Sorted Z-values histogram for motif Sox2

Sorted Z-values for motif Sox2



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_143933089 6.802 ENSMUST00000087313.3
 Dcx
doublecortin
chr10_+_80300997 6.064 ENSMUST00000140828.1
ENSMUST00000138909.1
 Apc2

adenomatosis polyposis coli 2

chr10_-_29144194 4.234 ENSMUST00000070359.2
 Gm9996
predicted gene 9996
chr1_-_64122256 3.812 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr14_+_61138445 3.778 ENSMUST00000089394.3
ENSMUST00000119509.1
 Sacs

sacsin

chr19_-_4334001 3.723 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A
chr2_+_4559742 3.557 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A
chr5_-_112228633 3.535 ENSMUST00000182699.1
ENSMUST00000182258.1
ENSMUST00000183036.1
 Miat


myocardial infarction associated transcript (non-protein coding)


chr1_+_66322102 3.534 ENSMUST00000123647.1
 Map2
microtubule-associated protein 2
chr2_-_25983056 3.421 ENSMUST00000127823.1
ENSMUST00000134882.1
 Camsap1

calmodulin regulated spectrin-associated protein 1

chr11_+_3649759 3.374 ENSMUST00000140242.1
 Morc2a
microrchidia 2A
chr7_-_74013676 3.223 ENSMUST00000026896.4
 St8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr14_+_25607797 3.168 ENSMUST00000160229.1
 Zmiz1
zinc finger, MIZ-type containing 1
chr7_+_112679327 3.086 ENSMUST00000106638.2
 Tead1
TEA domain family member 1
chr10_+_29143996 3.011 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr13_-_54687644 3.006 ENSMUST00000129881.1
 Rnf44
ring finger protein 44
chr4_+_54945038 2.823 ENSMUST00000133895.1
 Zfp462
zinc finger protein 462
chr2_-_6721890 2.791 ENSMUST00000114927.2
 Celf2
CUGBP, Elav-like family member 2
chr2_-_6722187 2.753 ENSMUST00000182657.1
 Celf2
CUGBP, Elav-like family member 2
chr5_+_105415738 2.727 ENSMUST00000112707.1
 Lrrc8b
leucine rich repeat containing 8 family, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 408 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 7.8 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 7.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 6.0 GO:0006376 mRNA splice site selection(GO:0006376)
1.2 5.9 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.6 5.7 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.7 5.6 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.5 5.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.5 5.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.4 4.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 4.7 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.9 4.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 4.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.5 4.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.4 4.1 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 4.1 GO:0022027 interkinetic nuclear migration(GO:0022027)
1.3 4.0 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.5 3.9 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 3.8 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 3.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 12.2 GO:0060076 excitatory synapse(GO:0060076)
0.0 10.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 8.2 GO:0005871 kinesin complex(GO:0005871)
0.6 7.5 GO:0097418 neurofibrillary tangle(GO:0097418)
0.8 7.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 5.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 4.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 4.2 GO:0031430 M band(GO:0031430)
1.0 4.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 4.0 GO:0090544 BAF-type complex(GO:0090544)
0.1 3.9 GO:0005884 actin filament(GO:0005884)
0.0 3.6 GO:0030427 site of polarized growth(GO:0030427)
0.2 3.5 GO:1990635 proximal dendrite(GO:1990635)
0.8 3.4 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 3.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 3.3 GO:0055037 recycling endosome(GO:0055037)
0.0 3.2 GO:0016605 PML body(GO:0016605)
0.1 3.0 GO:0002102 podosome(GO:0002102)
0.1 3.0 GO:0031941 filamentous actin(GO:0031941)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.5 GO:0008017 microtubule binding(GO:0008017)
0.3 15.7 GO:0030507 spectrin binding(GO:0030507)
0.0 11.9 GO:0005096 GTPase activator activity(GO:0005096)
0.2 9.4 GO:0036002 pre-mRNA binding(GO:0036002)
1.0 8.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 7.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 7.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 7.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 7.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 7.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 6.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 6.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.8 5.7 GO:0099609 microtubule lateral binding(GO:0099609)
0.4 5.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 5.2 GO:0070325 lipoprotein particle receptor binding(GO:0070325)
0.0 4.7 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 4.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.6 4.4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.2 4.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.4 3.9 GO:0035374 chondroitin sulfate binding(GO:0035374)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 12.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 6.7 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.2 6.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 5.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 5.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 5.2 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 3.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 3.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.7 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.6 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 2.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 2.0 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 2.0 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 1.9 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 10.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.2 5.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 5.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 5.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 5.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 4.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 4.4 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.2 4.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 4.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 3.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.9 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 3.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 3.0 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.5 REACTOME_REGULATION_OF_SIGNALING_BY_CBL Genes involved in Regulation of signaling by CBL
0.1 2.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.5 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.2 2.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.2 2.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 2.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo